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Histone chaperone

The assembly of nucleosomes is mediated by one of several chromatin assembly factors facilitated by histone chaperones, proteins such as the anionic nuclear protein nucleoplasmin. As the nucleosome is assembled, histones are released from the histone chaperones. Nucleosomes appear to exhibit preference for certain regions on specific DNA molecules, but the basis for this nonrandom distribution, termed phasing, is not completely... [Pg.315]

Adkins MW, Tyler JK (2004) The histone chaperone Asflp mediates global chromatin disassembly in vivo. J Biol Chem 279 52069-52074... [Pg.40]

Akey CW, Luger K (2003) Histone chaperones and nucleosome assembly. Curr Opin Struct Biol 13 6-14 Aoyagi S, Hayes JJ (2002) hSWI/SNF-catalyzed nucleosome sliding does not occur solely via a twist-diffusion mechanism. Mol Cell Biol 22 7484—7490... [Pg.40]

More recent studies in Drosophila revealed that H3.3 also plays an important role in the male pronucleus after fertilization (Loppin et al. 2005). The loss of the H3.3 chaperone HIRA impairs the replacement of paternal non-histone proteins from the sperm nucleus with maternally provided histones including H3.3, while the maternal genome exclusively contains the canonical H3. Thus, H3.3 and its deposition factor HIRA function in early fertilization events and might have a role in imprinting in higher eukaryotes. [Pg.95]

Abstract Histone chaperones are the histone interacting factors that stimulate histone transfer... [Pg.111]

Histone chaperones are the physiological chromatin assembly factors, which are crucial to regulate the deposition of histones onto DNA in vivo, both in replication dependent and independent manner. The chromatin assembly factor 1 (CAF-1) initiates the replication dependent chromatin assembly. The newly synthesized... [Pg.112]

Table 1. Functional Diversity among Histone Chaperones (Based on Haushalter and Kadonaga, 2003)... Table 1. Functional Diversity among Histone Chaperones (Based on Haushalter and Kadonaga, 2003)...
N1/N2 H3-H4 Storage of histones in oocytes Chaperone activity during rapid replication... [Pg.113]

FKBP H2A-H2B (dimer) H3-H4 (tetramer) Histone chaperone regulating rDNA silencing... [Pg.113]

Figure 1. Different histone chaperones in the key histone metabolic pathways Functions of histone chaperones range from the storage of newly synthesized histones in the cytoplasm, its transfer into the nucleus and in histone assembly into nucleosomes. Apart from diis die histone chaperones are also involved in histone exchange, maintenance of heterochromatin and in the regulation of chromatin structure during transcription. (See Colour Plate 10.)... Figure 1. Different histone chaperones in the key histone metabolic pathways Functions of histone chaperones range from the storage of newly synthesized histones in the cytoplasm, its transfer into the nucleus and in histone assembly into nucleosomes. Apart from diis die histone chaperones are also involved in histone exchange, maintenance of heterochromatin and in the regulation of chromatin structure during transcription. (See Colour Plate 10.)...
Figure 2. Histone chaperones facilitate favorable chromatin dynamics during transcriptional activation Transcriptional competence of chromatin template is achieved by die replacement of histone variants and finally removal of histones. Histone chaperone may help in bodi die process in a replication independent manner. Acetylation of histone and also die chaperone may assist in diis process. Recent evidence suggest that NPMl may participate in these events globally or gene specific manner. (See Colour Plate 11.)... Figure 2. Histone chaperones facilitate favorable chromatin dynamics during transcriptional activation Transcriptional competence of chromatin template is achieved by die replacement of histone variants and finally removal of histones. Histone chaperone may help in bodi die process in a replication independent manner. Acetylation of histone and also die chaperone may assist in diis process. Recent evidence suggest that NPMl may participate in these events globally or gene specific manner. (See Colour Plate 11.)...
Sensing DNA damage is essential for maintenance of genomic integrity and cell cycle progression. DNA repair is the second major site of DNA synthesis in a cell after replication and it involves chromatin assembly after efficient repair process. In yeast, the histone chaperone CAF-1 (chromatin Assembly factorl) mediates histone H3-H4 assembly on to newly replicated DNA and also mediates nucleotide... [Pg.118]

Figure 3. (a) Scheme of transcription, (b) Histone chaperone nucleophosmin/NPMl enhance acetylation dependent chromatin transcription NPMl stimulates chromatin transcription in a dose dependent manner. Lane 1,without activator lanes 2-6, with the activator Gal-VP16 (50 ng) lanes 3-6, with p300 (25 ng) lanes 4-6, with acetyl CoA (1.5 pM) lane 5, 1 pmol, lane 6, 10 pmols of full length NPMl... [Pg.119]

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See also in sourсe #XX -- [ Pg.315 ]



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