Norepinephrine

Certain biogenic amines, including 5-hydroxytrypt-amine (serotonin), L-norepinephrine, and P-phenyl-ethylamine, are removed from pulmonary circulation whereas others, such as histamine, dopamine, and epinephrine generally are not (Gillis and Greene 1977). 

Tetrachlorodecaoxygen (20 pM), a wound healing agent, relaxed isolated calif pulmonary arteries precontracted with 0.5 pM serotonin, which was rapidly accelerated by addition of 1 pM reduced haemoglobin with or without 20 pg/ml catalase + 10 pg/ml superoxide dismutase (Wolin et al. 1994). 

Indole derivatives autoxidize in the presence of transition metals presumable to nitrogen-centred radicals. Serotonin for a substrate in the H2O2-peroxidase reaction system incubated with 200 pM GSH took up 63.1 7.1 pM oxygen (O Brien 1988). The one-electron oxidation potential of indole derivatives is not known, but indoles slowly reduce cytochrome c, which suggests that the potential is less than that for cytochrome c (Perez-Reyes and Mason 1981). 

In isolated male Sprague-Dawley rat lungs perfused for 6 min at 10 ml/min by a peristaltic pump, H-L-norepinephrine (10 pM) was rapidly deaminated and 0-methylated, and the metabolic products were subsequently returned to the perfusate (Nicholas 

Endothelin inhibited the evoked H-norepi-nephrine overflow in guinea-pig pulmonary artery (WiKLUND et al. 1989). 

(1990). Nomenclature of Inorganic Chemistry. Oxford, U.K Blackwell Science. (This title is often referred to as the Red Book, or since 2001, Red Book I.) 

(1998). Principles of Chemical Nomenclature. Oxford, U.K. Blackwell Science. 

McCleverty, J. A., and Connelly, N. G., eds. (2000). Nomenclature of Inorganic Chemistry II. Cambridge, U.K The Royal Society of Chemistry. (This is sometimes referred to as Red Book II.) 

Rigaudy, J., and Kesney, S. P., eds. (1979). Nomenclature of Organic Chemistry. Oxford, U.K. Pergamon Press. 

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FIGURE 27 5 Tyrosine is the biosynthetic precursor to a number of neurotransmit ters Each transformation IS enzyme catalyzed Hydroxy lation of the aromatic ring of tyrosine converts it to 3 4 dihyd roxyphenylalanine (l dopa) decarboxylation of which gives dopamine Hy droxylation of the benzylic carbon of dopamine con verts It to norepinephrine (noradrenaline) and methy lation of the ammo group of norepinephrine yields epi nephrine (adrenaline)... 

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