Perfused dog lung

Widman, M. et al., Metabolism of deltal-tetrahydrocannabinol by the isolated perfused dog lung comparison with in vitro liver metabolism, 3. Pharm. Pharmacol., 27(11), 842-848, 1975. 

The pressure response to endothelin-1 in the canine circulation has been investigated in isolated perfused dog lung (74). Acute treatment of the isolated lobes with fenfluramine increased pulmonary arterial pressure. Chronic treatment with fenfluramine potentiated the pulmonary vasoconstrictor response to endothelin-1. Based on these findings, the authors proposed that the pulmonary vasculature becomes hyper-reactive to vasoactive substances, such as serotonin and endothelin-1, possibly leading to pulmonary hjrpertension. 

Widman M, Nordqvist M, Dollery CT, Briant RH (1975) Metabohsm of delta-1-tetrahydrocannabinol by fhe isolated perfused dog lung. Comparison with in vitro liver metabolism. J Pharm Pharmacol 27 842-848... 

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