Side Effects of Norepinephrine-Blocking Medications

Blocking the beta receptor can lower blood pressure, slow heart rate, trigger erectile dysfunction (impotence), or worsen breathing difficulties in patients with asthma or emphysema. The best way to manage these side effects is to use the lowest effective dose. If the side effects remain intolerable at the least effective dose, then it s probably necessary to switch to an alternative medication. 

Blocking the Alpha-1 Receptor. Blocking the alpha-I receptor can also reduce norepinephrine activity. There is no apparent psychiatric benefit to blocking alpha-1 receptors, and unfortunately, many psychiatric medications do just that, resulting in side effects. 

Blockade of alpha-1 receptors is associated with orthostatic hypotension. Have you ever gotten dizzy when you got out of bed or stood up from a chair too quickly This happens because your blood pressure falls briefly when you abruptly change 

TABLE 13.3. Medications that Reduce Norepinephrine Activity 

Medication Means of Reducing Norepinephrine (NE) Activity Prominent Effects on Other Transmitters Psychiatric Uses 

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