Noradrenaline tartrate

Synonyms. Noradrenaline Tartrate Norepinephrine Bitartrate. Proprietary Names. Levophed Noradrec. 

C. It is secreted along with noradrenaline by the adrenal medulla, from which it may be obtained. It may be synthesized from catechol. It is used as the acid tartrate in the treatment of allergic reactions and circulatory collapse. It is included in some local anaesthetic injections in order to constrict blood vessels locally and slow the disappearance of anaesthetic from the site of injection. Ultimately it induces cellular activation of phosphorylase which promotes catabolism of glycogen to glucose. 

Adrenaline Noradrenaline Dissolve 5.0 mg in 1 ml of a 0.5% w/v soln. of tartaric acid and 4 ml of buffer soln. pH 9.6, mix, add 1 ml freshly prepared 0.5% w/v soln. of sodium l,2-naphthaquinone-4-sulphonate, mix and allow to stand for 30 mts. Add 0.2 ml of a 1.0% v/v soln. of benzalkoniumchloride soln., mix, add 15 ml of toluene previously washed with buffer soln. pH 9.6 and filtered through a dry filter paper, shake for 30 mts. and allow to separate, centrifuging if necessary. Any red or purple colour in the toluene layer is not darker than that produced by treating a soln. of 0.40 mg of noradrenaline and tartrate and 9 mg of noradrenaline free adrenanline acid tartate in 1 ml of DW in a similar manner. 

Infra-red Spectrum. Principal peaks at wavenumbers 1265,1293, 1216,1200,1066,1137 (noradrenaline acid tartrate, KBr disk). 

Diquat Dibromide Distigmine Bromide Ethyl Nicotinate Gallamine Triethiodide Hexamethonium Bromide Hydrastinine Mebezonium Iodide Neomycin Noradrenaline Paraquat Dichloride Pentolinium Tartrate Quinuronium Sulphate Streptomycin Tubocurarine Chloride... 

Drugs that contain two phenolic groups, such as adrenaline (epinephrine) and other catecholamines such as noradrenaline (norepinephrine) and isoprenaline are particularly susceptible to oxidation and have to be formulated at acidic pH. All of these compounds are white crystalline solids that darken on exposure to air. Adrenaline forms the red coloured compound adrenochrome on oxidation (Figure 8.10), which can further polymerise to give black compounds similar in structure to melanin, the natural skin pigment. Injections of adrenaline that develop a pink colour, or that contain crystals of black compound, should not be used for this reason. Adrenaline for injection is formulated as the acid tartrate... 

Precaution Probably combustible incompat. with calcium chloride, noradrenaline acid tartrate, pentobarbitone sodium, kanamycin Hazardous Decomp. Prods. Heated to decomp., emits very toxic fumes of chlorine and NOx HMIS Health 1, Flammability 0, Reactivity 0 Storage Store under ambient temps. 

Similar considerations apply to noradrenaline where again the /-isomer is more potent than the method using values of 1-1423 and 80 for the gravimetric and rotatory factors, respectively. 

Noradrenaline is used therapeutically as its add tartrate which is fredy soluble in water. 

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