Noninvasive diagnostics

Keywords Chemical sensors Point contact Exhaled air analysis Point-contact spectroscopy Organic conductors Noninvasive diagnostics Chronic dyspepsia... 

This study demonstrates high efficacy and expediency of the TCNQ derivative-based point-contact multistracture as a prospective asset for development of new sensors. The complex character of the sensors response curve and correlation of some response characteristics with different pathological manifestations in human breath, may be further used as a noninvasive diagnostic method alternative to some invasive approaches currently routinely used in clinic. The need for reliable and feasible gas analysis methods functional in presence of atmospheric air, opens opportunities for application of the proposed sensor technique in other spheres of human activity. High sensitivity of the point-contact multistructure enabling analysis of composite gas mixtures, opens up wide possibilities to apply the demonstrated approach for environment and health protection, such as detection of trace amounts... 

Topaz O, Taylor AL, Interventricular septal rupture complicating acute myocardial infarction from pathophysiologic features to the role of invasive and noninvasive diagnostic modalities in current management. Am J Med 1992 93(6) 683-688. Review. 

One of the most successful radiopharmaceuticals in oncology (and in other fields of noninvasive diagnostic medicine) is certainly lsF-labeled glucose, 2-lsF-2-deoxy-glucose, so-called FDG [60]. FDG is taken up by the glucose transporters GLUT,... 

Brubaker RF, Maurice DM, McLaren JW. Fluorometry of the anterior segment. In Masters BR, ed. Noninvasive diagnostic techniques in ophthalmology. New York Sprrnger-Verlag, 1990 248-280. 

A wide range of invasive and noninvasive diagnostic tests for H, pylori has been described as shown in Box 48-1. 

Inhalation of hypertonic saline is a noninvasive diagnostic test using nonradioactive aerosols and results in expectoration of sputum. The cellular content of the sputum, related to the degree of inflammation present in the lung in asthma, is then measured using specific laboratory techniques and provides an objective means of monitoring the disease and the effectiveness of antiinflammatory therapy. Scheduling of these tests, either pre- or postinhalation of the tracer aerosol, would be determined by the clinical question or the research objective. 

Patients with pulmonary hypertension often complain of exertional dyspnea, chest pain, and syncope. Due to the nonspecific nature of these symptoms and lack of a noninvasive diagnostic test for detecting pulmonary hypertension, there are often delays in the... 

Early detection markers include two major groups. The first group is molecular markers that can be applied to tissue biopsies in order to better stratify at-risk groups. The second group is cancer-associated markers that can be detected in blood, urine, ejaculates, or prostatic massage fluid as a noninvasive diagnostic alternative to needle biopsy. 

As stated above, MRS provides a noninvasive diagnostic tool for the biochemical characterization of pathophysiological processes in the brain. Therefore, in a recent study by Akinci et al. (2006), MRS was used to detect the changes in brain metabolites of neonates with hypothyroidism, born to mothers living in iodine-deficient areas before and after thyroxine replacement therapy. 

Development of the first computer-based medical instrument, the computerized axial tomography scanner, revolutionized cHnical approaches to noninvasive diagnostic imaging procedures, which now include magnetic resonance imaging and positron emission tomography as well. 

The most novel of the noninvasive techniques involves evaluation of microvolt T-wave altemans (MTWA). This noninvasive diagnostic approach detects minute changes in electrical activity in the T-wave as it alternates in shape, amplitude, and timing beat by beat A positive MTWA test has been linked to inducible (48-51) and spontaneous (57,58) maUgnant ventricular arrhythmias. 

Although ischemic disease makes up a large proportion of the overall patient population, there is a stunning variety of other cardiac diseases that also need to be addressed in noninvasive diagnostic procedures. This variety include diseases such as the entire range of CHD, the widespread range of cardiomyopathies and inflammatory diseases, and cardiac tumors. 

Noninvasive Diagnostic Evaluation of Peripheral Arterial Disease... 

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