Ischemic disease

The partial oxygen pressure, p02, is particularly significant in metabolic processes of cells, and its variation from normal values often indicates pathologies (ischemic diseases, strokes, tumors). Accurate and localized measurements of the oxygen concentration are also desirable for differentiation between venous and arterial blood, or for cerebral mapping of task activation. In the past, invasive methods were used involving oxygen-sensitive electrodes which had to be placed directly in the blood or tissue and could only offer p02 from a few body points. 

Losordo DW, Dimmeler S. Therapeutic angiogenesis and vasculogenesis for ischemic disease part II cell-based therapies. Circulation 2004 109 2692-2697. 

Prevention or Diagnosis of Ischemic Disease Before Irreversible Remodeling Occurs... 

Greater efforts must be employed to increase the awareness of heart failure in the public eye, specifically the financial burden that it entails as well as the significant morbidity and mortality associated with the diagnosis. Optimization of accepted treatments must be explored on larger scales in patients with ischemic disease and made more widely and... 

The use of bone marrow has also been explored in chronic ischemic disease [40 2]. Results are striking but with the small sample sizes of the studies, the results are difficult to interpret. There is a difficulty in choosing the correct cell line. An ideal cell population would (1) be readily and widely available, (2) have the ability to generate new cardiac myocytes, (3)... 

Endothelins are a family of vasoactive peptides secreted by endothelial cells. The three major endothelin peptides are all composed of 21 amino acids. Endothelins are the most potent vasoconstrictors known. Contraction of vascular smooth muscle in response to endothelin is associated with an increase in intracellular calcium. Increases in endothelin levels have been reported in patients with vasospastic, hypoxic, and ischemic diseases. The two identified isoforms of endothelin receptors have differing affinity for the three endothelin peptides. Selective and nonselective endothelin receptor antagonists are in development for potential use in the treatment of hypertension and other disorders associated with increased vascular resistance. 

In patients with known CHD the 4S (16), Cholesterol and Recurrent Events (CARE) (17) and Long-term Intervention with Pravastatin in Ischemic Disease (LIPID)... 

Therapeutic angiogenesis is an emerging strategy for treating ischemic diseases by inducing new blood vessel growth in... 

Excitotoxic neuronal death is a common feature of neurodegenerative and ischemic diseases of the central nervous system (CNS) and of a variety of ocular diseases, including glaucoma. 

Centocor ReoPro (Abciximab) Chimeric Heart ischemic disease 1994... 

LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. The Long-term intervention with Pravastatin in Ischemic Disease (LIPID) Study Group. N. Engl.J. Med., 1998, 339, 1349-1357. 

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