Missed opportunity

It is also the responsibihty of management to estimate the probabilities for the success of individual projects after due consideration of all the data provided by the various departments. The rate of return on investment that is acceptable to management is a function of these responsibihties. Each industry has a reasonably well defined return on investment that reflects the degree of risk inherent in that industry. If management decisions are faulty, the company either will overspend or will miss opportunities. 

Missed opportunities occur when it becomes clear that had a piece of information been available or used correctly at a particular point in time, a better decision could have been made than the one that was actually made at that time. Examples of missed opportunities are ... 

By definition they only become apparent with hindsight, so tackling missed opportunities involves historical analysis of information generation and use, and decisions made. 

Although 500,000 individuals were enrolled in clinical trials that were submitted to the FDA during 1990-1995 [10], the lack of a repository of clinical trial data, standardized data, and interoperable systems precludes us from efficiently tapping and reanalyzing these data. This missed opportunity underscores the need for standardization and interoperable systems, as discussed above (see Section 27.4.1 on data standards and interoperable systems). 

Water systems can be very complex to study and potentially require an enormous amount of data if a whole site is to be studied. Understanding the data requirements more fully can prevent collection of unnecessary data and avoid missed opportunities. 

Clearly 2 to 5 mil coatings can significantly alter fire performance. Proper evaluation and choice of coating for fire performance is an important, and often missed, opportunity. 

Therefore the protection ART offers against OIs is a missed opportunity in this population. Finally some individuals do not achieve immunologic responses despite receiving ART and are therefore still prone to developing OIs. This is especially the case when ART is initiated with advance immune deterioration, a common occurrence in RLS. The following section therefore highlights several aspects of the treatment and prevention of important OIs in RLS. 

The analysis proposed by Taguchi involves the construction of a signal-to-noise ratio that combines both the mean and variability. Thus, with Taguchi s analysis there is a missed opportunity for a deeper understanding of the different variability that might affect the mean and the variability. 

By chance in 1970, we conjectured the possibility of the football-shaped C60 molecule, now known as buckminsterfullerene, while considering superaromatic molecules having three-dimensional ji-electron delocalization. A translation of the original description, initially written in Japanese, is given. The processes leading to scientific discoveries are analysed in the light of our missed opportunity. 

Pasteur s famous experiments with tartrate crystals have been described,161 the sesqui-centenary of their start being marked by a paper that examined missed opportunities in stereochemistry and, in particular, the work by Mitscherlich which nearly anticipated Pasteur.162 The centenary in 1995 of Pasteur s death prompted publication of several papers.163-165 His observations, and those of le Bel and van t Hoff, are described in a paper outlining the reasoning that led to the momentous recognition of the tetrahedral carbon atom.166 The reception of a tetrahedral carbon atom was varied. Its application to the relatively new Kekule structure for benzene was made by van t Hoff himself and more particularly by Wilhelm Komer.167 Eventual support came from Wislicenus, a widely ranging organic chemist, noted specially for his work on isomerism.168... 

You must always believe that there is fertile soil for your ideas. If you lose hope then you will miss opportunities to plant a seed. 

A big disadvantage for staff below the Manager level within the R D function is that they mostly stay within their own environment, with a tendency to become isolated from the activities of their colleagues in the broader business. This can lead to missed opportunities for new business ideas, constructive appointments to job va-... 

Fast shallow testing of many compounds involves two types of risks, that of false positives (over-optimistic evaluation), and that of false negatives (missed opportunities). 

The discovery of deuterium is, according to one of the physicists who participated in the experiments that led to its discovery, a story of missed opportunities and errors. In 1913, two scientists at New %rk University held the discovery of deuterium in their hands when they measured the density of water to great accuracy. They found that the density of water varied from sample to sample and concluded that pure water does not possess a unique density. Their results varied according to the varying presence of deuterium in their samples. This was the first experimental evidence that provided a hint of the existence of deuterium. Had these scientists responded to their results with an experiment... 

Smith, S.C., Jr., Clinical treatment of dyslipidemia practice patterns and missed opportunities. Am. J. Cardiol, 86, 62L, 2000. 

All emphasis on simplification notwithstanding, the development of reliable reaction mathematics for design is an exacting job. Because scale-up by large factors may be involved, mechanisms that are merely plausible working hypotheses will not do the basis must be established beyond reasonable doubt. Incorrect kinetics is worse than none. In process development, kinetics is not a game for amateurs. Even in research, misinterpretation of kinetic observations may result in futile efforts and missed opportunities. The presentation here is geared toward the demand for exactitude. 

People who make discoveries do not necessarily use the aesthetic side until afterward. Then they recognize it and say, yeah, that s beautiful. Of course, we were not the first to find the boron icosahedron either. That was found by Sevastyanov and Zhdanov in C3B12, boron carbide, in 1941. That was a missed opportunity because nobody thought then that you could make fragments of this polyhedron and arrive at a structure of decaborane. That was not an idea that was around. It s an idea we missed. 

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