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Nociceptin/orphanin FQ receptor

Lambert DG The nociceptin/orphanin FQ receptor A target with broad therapeutic potential. Nat Rev Drug Discov 2008 7 694. [PMID 18670432]... [Pg.710]

Calo, G., Bigoni, R., Rizzi, A., Guerrini, R., Salvadori, S., Regoli, D. Nociceptin/orphanin FQ receptor ligands, Peptides 2000, 21, 935-947. [Pg.147]

Ozaki, S., Kawamoto, H., Itoh, Y., Miyaji, M., Iwasawa, Y., Ohta, H. A potent and highly selective nonpeptidyl nociceptin/orphanin FQ receptor (ORL1) antagonist J-113397, Eur. J. Pharmacol. 2000a, 387, R17-R18. [Pg.475]

Peluso J, LaForge KS, Matthes HW, Kreek Ml, Kieffer BL, Gaveriaux-Ruff C (1998) Distribution of nociceptin/orphanin FQ receptor transcript in human central nervous system and immune cells. J Neuroimmunol 81 184-192. [Pg.493]

ORL-1 receptor also known as the nociceptin/orphanin FQ receptor—a G-protein-coupled receptor for which the endogenous ligand is nociceptin. [Pg.784]

Activation of the nociceptin/orphanin FQ receptor reduces bronchoconstriction and microvascular leakage in a rabbit model of gastroesophageal reflux. Br J Pharmacol 144(6) 813-20... [Pg.122]

Toll L. Comparison of the anti-nociceptive and anti-rewarding profiles of novel bifimction nociceptin/ orphanin FQ receptor (NOPr)-mu opioid receptor (MOPr) ligands implications for theurapeutic applications. / Pharmacol Exp 77/er2009 331(3) 954-964. [Pg.512]

The four opioid receptors display in vivo binding preference for mu-endorphins and endomorphins, delta-enkephalins, kappa-dynorphin and ORLl-nociceptin/orphanin FQ (Table 12.2). [Pg.258]

Compound 24 represents a series of potent spiropiperidine GlyT-1 inhibitors that showed significant binding to the p opioid and nociceptin/ orphanin FQ peptide (NOP) receptors [67]. The hydroxy analog 25 demonstrated improved selectivity and N-propyl analog 26 exhibited increased microsomal stability but reduced GlyT-1 potency (EC50 = 450 nM) [68]. [Pg.27]

Meunier, J.-C. Nociceptin /orphanin FQ and the opioid receptor-like ORL1 receptor, Eur. J. Pharmacol. 1997, 340, 1-15. [Pg.474]

Schlicker E, Kathmann M (2000) Modulation of the release of noradrenaline and other transmitters via cannabinoid and opioid receptors. Fundam Clin Pharmacol 14 64 Schlicker E, Morari M (2000) Nociceptin/orphanin FQ and neurotransmitter release in the central... [Pg.433]

Experimental agents were evaluated in a receptor binding assay with 3H-nociceptin/orphanin FQ with membranes of recombinant CHO-ORLj cells according to the method of Ardati (1). Testing results are provided in Table 2. [Pg.104]

Inoue K, Tsuda M, Tozaki-Saitoh H (2007) Modification of neuropathic pain sensation through microglial ATP receptors. Purinergic Signal 3 311-316 Inoue M, Kawashima T, AUen RG, Ueda H (2003) Nodstatin and prepro-nociceptin/orphanin FQ 160-187 cause nociception through activation of Gj/o in capsaidn-sensitive and... [Pg.502]

Henderson. G. et al. (1997) The orphan opioid receptor and its endogenous ligarKl - nociceptin/orphanin FQ. Trends Pharmacol. ScL. 18.293-300. Alexander. S.P.H. er al. (1998) Receptors and ion channel nomenclature supplement. Ninth Edition. Trends Pharmacol. Sci.. Su/. . IS, 1-98. [Pg.209]

Henderson G, McKnight AT. The orphan opioid receptor and its endogenous ligand —nociceptin/orphanin FQ. Trends Pharmacol Sci 1997 18 293-300. [Pg.1014]

Zeilhofer HU, Calo G. Nociceptin/orphanin FQ and its receptor-potential targets for pain therapy J Pharmacol Exp Ther 2003 306 423-429. [Pg.1014]

McKemy DD, Neuhausser WM, Julius D (2002) Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature 416 52-58 McLeod RL, Bolser DC, Jia Y, Parra LE, Mutter JC, Wang X, Tulshian DB, Egan RW, Hey JA (2002) Antitussive effect of nociceptin/orphanin FQ in experimental cough models. Pulm Pharmacol Ther 15 213-216... [Pg.183]

Nociceptin (orphanin FQ) is a novel neuropeptide whose actions have yet to be completely elucidated. However, stimulation of the nociceptin receptor has been implicated in the modulation of many neurobehavioral processes, including pain, substance dependence, sexual behavior, anxiety, locomotor activity, learning capacity, memory, and adaptation to stressful stimulus [1-6]. Continued research in this area has the potential to lead to a new class of drugs for pain medicine and beyond. [Pg.508]

In addition to pain modulation, nociceptin/orphanin FQ has been implicated in reducing, or even completely blocking, the rewarding effects and tolerance of substances that have abuse and dependency potential. NC and its receptor are located throughout the... [Pg.510]

The relatively recent discovery of the neuropeptide nociceptin/orphanin FQ, and its receptor system, offers the possibility of future treatment modahties in the field of pain medicine. As described, this system can play a role in pain rebel, anxiolysis, and substance abuse associated with opioids, and other central-acting drugs. Although much research remains, these potential effects with regard to pain, anxiety, and substance abuse, as web as numerous other systemic effects, encourage further work in the area. [Pg.511]

See other pages where Nociceptin/orphanin FQ receptor is mentioned: [Pg.552]    [Pg.784]    [Pg.552]    [Pg.784]    [Pg.1498]    [Pg.258]    [Pg.468]    [Pg.327]    [Pg.356]    [Pg.467]    [Pg.571]    [Pg.514]    [Pg.529]    [Pg.784]    [Pg.200]    [Pg.451]    [Pg.976]    [Pg.66]    [Pg.69]    [Pg.74]    [Pg.124]    [Pg.165]    [Pg.291]    [Pg.509]    [Pg.269]    [Pg.373]   
See also in sourсe #XX -- [ Pg.165 ]



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