Nitroprusside salts

Nitroprusside Salt and water retention Cyanide toxicity (CN released)... 

These, and related, iron nitrosyl compounds have excited considerable interest because of their biological activity.Nitroprusside induces muscle relaxation and is therefore used to control high blood pressure. Roussin s black salt has antibacterial activity under conditions relevant to... 

Hydrogen cyanide (HCN) is a colorless, highly poisonous gas or liquid (below 26.7 °C) having an odor of bitter almonds (Hartung 1994 Pesce 1994). It is a weak acid. Exposures may occur in industrial situations as well as from cigarette smoke and combustion products and from naturally occurring cyanide compounds in foods. There is a potential for exposure when any acid is mixed with a cyanide salt. Intravenously administered sodium nitroprusside (Na2[Fe(CN)5N0]-2H20) has been used clinically to lower blood pressure (Schulz et al. 1982). Chemical and physical properties are listed in Table 5-2. 

Testing for Sulphur.—The qualitative test for sulphur is carried out in the same way as that for nitrogen. Ignite the substance in a small tube with sodium, dissolve the product in water, and add to one half of the cooled solution a few drops of sodium nitroprusside solution freshly prepared by shaking a few particles of the solid salt with cold water. A violet colour indicates the presence of sulphur. Since the nitroprusside reaction is extremely sensitive and does not allow any estimate of the amount of sulphur to be made, filter the second half of the liquid, add lead acetate solution to the filtrate, and acidify with acetic acid. According as the amount of sulphur is small or large, a dark turbidity or a more or less heavy precipitate will form. 

The second salt presents a structure where the anions occupy the tunnels formed by BEDT-TTF dimers. BEDT-TTF bears the unit positive charge. This salt behaves like a semiconductor with a very low room-temperature electric conductivity. The unpaired electrons on the organic cation-radicals are strongly antiferromagnetic coupled, giving rise to a diamagnetic behavior of the second salt, because the nitroprusside anion is also diamagnetic. 

Reaction of the manganese tropocoronand complex [Mn(tc-5,5)(NO)] with [Fe(tc-5,5)] results in complete transfer of the NO to the [Fe(tc-5,5)]. Other nitric oxide complexes appear in the sections on nitroprusside (Section S.4.2.2.6 above), on phthalocyanines (Section 5.4.3.7.4 above), and on polynuclear iron-sulfide complexes (Roussin s salts Section 5.4.5.9.2 below) Fe-por-phyrin-NO redox chemistry has been mentioned in Section 5.4.3.7.2 above. 

As previously stated, the addition of a copper salt to hydrazine reduces the induction period practically to zero. The addition of sodium nitroprusside exerts a similar influence. 

Poisoning with cyanide may occur in a variety of ways accidental or intentional poisoning with cyanide salts, which are used in industry or in laboratories as a result of exposure to hydrogen cyanide in fires when polyurethane foam burns from sodium nitroprusside, which is used therapeutically as a muscle relaxant and produces cyanide as an intermediate product and from the natural product amygdalin, which is found in apricot stones, for example. 

The synthesis, structure, and electrical and magnetic characteristics were recently described for two other salts formed with BEDT-TTF and hexacyanoferrate, (Et4N+)3 [Fe(CN)6 3 or nitroprusside, K2 [Fe(CN)5NO]2. The study sheds light on the general peculiarities of making two-network solids by combining magnetic anions, which provide lo-... 

Hydrated tris(phenylbiguanide)cobalt(III) chloride forms needle-shaped, red crystals which are soluble in water and alcohol but insoluble in ether and acetone. When heated to 110° for 15 hours, the hydrate loses the whole of its water to form the red anhydrous salt. The solution of the complex chloride gives colored precipitates with a number of complex anions such as hexacyanoferrate(II), hexacyano-ferrate(III), nitroprusside, hexacyanocobaltate(III), and chloroplatinate. 

Sodium nitroprusside-zinc sulphate test Sodium nitroprusside solution reacts with a solution of a zinc salt to yield a salmon-coloured precipitate of zinc nitroprusside Zn[Fe(CN)5NO], The latter reacts with moist sulphur dioxide to give a red compound of unknown composition the test is rendered more sensitive when the reaction product is held over ammonia vapour which decolourizes the unused zinc nitroprusside. 

Sodium nitroprusside, Na2[Fe(CN)5N0].2H20 Sodium oxalate (Sorensen s salt), (COONa)2 Sodium perborate, NaB03.4H20... 

Sodium nitroprusside,5 Na2[Fe(CN)6N0]2H20, which is usually obtained by decomposing the potassium salt with sodium carbonate. Potassium carbonate is exceedingly soluble in water, so that sodium nitroprusside is readily obtained in pure form by crystallisation. 

When potassium ferricyanide is warmed with a solution of bleaching powder to 70° C. a considerable evolution of gas takes place, and a reddish deposit of ferric oxide and calcium carbonate is formed. The filtered solution is concentrated and the potassium nitroprusside extracted with alcohol, and converted into the insoluble copper salt by addition of cupric chloride. This latter is decomposed with sodium hydroxide, yielding the sodium salt, which may be further purified by dissolving in a little water, addition of alcohol, and subsequent evaporation after filtering off any insoluble material.2 The constitution to be assigned to sodium nitroprusside in particular, and hence to nitro-prussides in general, has been a subject of debate, Browning s3 formula is —... 

Ammonium nitroprusside, (NH4)2[Fe(CN)5NO]9 obtained by decomposing the barium salt with ammonium sulphate, crystallises m reddish plates, which are readily soluble in water.6... 

Barium nitroprusside, Ba[Fe(CN)5N0]3H20, is prepared by precipitating a solution of the sodium salt with zinc sulphate and boiling the zinc salt thus obtained with a suspension of precipitated barium carbonate. The filtered solution of the barium salt is evaporated under reduced pressure, and the salt crystallised from alcohol.6... 

Cobalt nitroprusside, Co[Fe(CN)6NO], obtained by double decomposition of a soluble cobalt salt with sodium nitroprusside, is a red salt, possessing an appreciable solubility in water. It dissolves in acids, but is insoluble in potassium hydroxide or ammonia solution. This latter property enables it to be separated from the corresponding nickel salt, which readily dissolves in ammonia.7... 

Nickel nitroprusside, Ni[Fe(CN)5NO], obtained in a similar manner to the preceding salt,8 is dark green when anhydrous, but upon exposure to moist air becomes ashen grey. It is insoluble in acids, but readily dissolves in ammonia to a brownish yellow liquid. Potassium hydroxide turns it lemon-yellow. 

Potassium nitroprusside, K2[Fe(CN)6NO], may be obtained by the interaction of a ferrous salt with the nitrite and cyanide of potash —9... 

When aqueous sodium nitroprusside solution is treated with sodium hydroxide, the quaternary nitrito sodium salt, Na4[Fe(CN)5NO2]10H2O, is obtained.4 It crystallises in yellowish red monosymmetric tablets, and is very soluble in water, yielding a dark red coloration with ammonium sulphide. 

When sodium hydroxide is allowed to react on a solution of sodium nitroprusside in methyl alcohol, the monohydrated 5 salt is obtained. Thus —... 

Sodium aquo ferrocyanide,2 Na3Fe(CN)s.H20, results when sodium nitroprusside reacts with hydroxylamine, etc., or when the salt is oxidised by potassium hypobromite or hydrogen peroxide. 

NSAIDs NITRATES Hypotensive effects of hydralazine, minoxidil and nitroprusside are antagonized by NSAIDs NSAIDs cause salt and water retention in the kidney and can raise BP due to 1 production of vasodilating renal prostaglandins Monitor BP at least weekly until stable... 

Treatment of 2 -deoxyguanosine with nitroprusside [Na2Fe(CN),N0] leads under alkaline conditions to the formation of the sodium salt of 2 -deoxyxanthosine (8). ... 

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