New chemicals strategy

These requirements have stimulated the research for new chemical strategies of coupling, and in particular for linkers that are easily cleaved. These include esters, lisosomotropic peptides that are stable in plasma but cleavable inside the cells by cathepsins [37], and spacers that can be directly cleaved under acidic conditions or by anchimeric assistance such as ds-citraconic acid amides or hydrazones derivatives [38]. Furthermore, pro-drug approaches or trimethyl lock systems have been developed where the carrier is cleaved in two steps, initially by water or enzymes and later by a chemical mechanism [39]. 

This chapter is written during the early days of the legislative process on the European Commission s New Chemicals Strategy and is a snapshot of the current position the final regulation may be changed from that which is outlined here and the reader must bear this in mind when doing further work on the subject. 

Select Committee on Science and TechnologyRelevant documents Within REACH, the EU s new chemicals strategy—Sixth Report from the Science and Technology Committee, Session 2003-04, HC 172-1, and the Government s response thereto, 7th Special Report, Session 2003-04, HC 895, Westminster Hall, Thursday 9 September 2004, 9 Sept 2004, Column 357WH, HC, UK House of Commons, London, UK, 2004. 

The purpose of this section is to provide a brief list of the new chemical strategies that have been developed to target these artificial functional groups because the importance of these teclmiques will undoubtedly grow in the coming years. 

Wright, G.D. Resisting resistance New chemical strategies for battling superbugs. Chem. Biol. 2000, 7(6), R127. 

Carniato, F. et al. (2013) Selective anchoring of Gdlll chelates on the external surface of organo-modifled mesoporous silica nanoparticles a new chemical strategy to enhance relaxivity. 

In several important cases, new synthetic strategies have been developed into new production schemes. An outstanding example of this is the production of an entire family of terpene derivatives from a-pinene (29), the major component of most turpentines, via linalool (3) (12). Many of these materials had been produced from P-pinene, a lesser component of turpentine, via pyrolysis to myrcene and further chemical processing. The newer method offers greater manufacturing dexibiUty and better economics, and is environmentally friendly in that catalytic air oxidation is used to introduce functionality. 

Synthesis remains a dynamic and central area of chemistry. There are many new principles, strategies and methods of synthesis waiting to be discovered. If this volume is helpful to our many colleagues in the chemical world in their pursuit of discovery and new knowledge, a major objective of this book will have been met. 

In the recent decades, an enzyme-catalyzed polymerization ( enzymatic polymerization ) has been of increasing importance as a new trend in macro-molecular science. Enzyme catalysis has provided new synthetic strategy for useful polymers, most of which are difficult to produce by conventional chemical... 

Hanessian, S., Bedeschi, A., Battistini, C., MongeUi, N. (1985) A New Synthetic Strategy for the Penems. Total Synthesis of (5R,6S,8R)-6-(a-Hydroxyethyl)-2-(hydroxymethyl)penem-3-carboxylic Acid. Journal of the American Chemical Society, 107, 1438-1439. 

Lastly, pharmacogenomics could provide new tools for the design of more specific and active CNS pharmaceuticals. The efficacy of a broad spectrum of neuro-pharmaceutical drugs is often complicated by their inability to reach their site of action because of the BBB. One way to overcome this is to use carrier-mediated transport at the luminal and/or abluminal membranes of the endothelial cells of the BBB. This will provide a physiologically based drug delivery strategy for the brain by designing new chemical entities or fused proteins that can cross the BBB via these transporters. 

Lefebure, Victor. The Riddle of the Rhine Chemical Strategy in Peace and War. New York E.P. Dutton Company, 1923. 

Aside from chemical innovation, biological strategies focus on new methods to study the effect of this neurotransmitter system on insomnia as well as on the possibilities for faster screening of new chemical entities, i.e, zebrafish models [91]. 

The main objective of the new EU Chemical Strategy is to ensure a high level of protection for human health and... 

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