Neurotoxicity other changes

Neurotoxicity Neurotoxicity, including tremor, headache, and other changes in motor function, mental status, and sensory function occurred in approximately 55% of liver... 

Studies of chronic exposure of those working in dry cleaning plants have reported some CNS effects, some liver function abnormalities, renal dysfunction, and some definite central and peripheral neurotoxicity. Other effects from chronic exposure to PERC include cardiac arrhythmias, reduced color perception, impaired memory, peripheral neuropathy, impaired vision, confusion, disorientation, fatigue, personality changes, and agitation. 

Some polymyxins are sold for second-line systemic therapy. Polymyxin B sulfate and colistimethate sodium can be used for intravenous, intramuscular, or intrathecal administration, especially for Pseudomonas aerupinosa mP QXiosis, but also for most other gram-negative organisms, such as those resistant to first-line antibiotics. Nephrotoxicity and various neurotoxicities are common in parenteral, but not in topical, use. Resistance to polymyxins develops slowly, involves mutation and, at least in some bacteria, adaptation, a poorly understood type of resistance that is rapidly lost on transfer to a medium free of polymyxin. Resistance can involve changes in the proteins, the lipopolysaccharides, and lipids of the outer membrane of the cell (52). Polymyxin and colistin show complete cross-resistance. 

Many of these tests gave evidence for changes in behavior following exposure to neurotoxic pesticides. The author concludes that significant behavioral effects were often recorded down to one order of magnitude below the LCjo in question. Some tests, such as operant tests, were relatively simple and gave reproducible results, but it was difficult to evaluate the relevance of these to survival in the wild. Other tests, such as breeding behavior and prey capture, were more complex and less reproducible, but more relevant to the natural world. 

Broadly speaking, the direct behavioral effects of neurotoxic pollutants on wild animals may be on feeding, breeding, or avoidance of predation (Beitinger 1990), or any combination of these. Any of these changes may have adverse effects on populations. Additionally, in the natural world, populations may be affected indirectly because of neurotoxic and behavioral effects on other species. Thus, a population decline of one species due to a behavioral effect of a pollutant may lead to a consequent decline of its parasites or predators, even though they are not themselves directly affected by the chemical. Direct effects will now be discussed before considering indirect ones. 

Rats that have lost dopamine and/or serotonin terminals following treatment with amphetamine, methamphetamine, MDMA, MDA, / -chloroamphetamine, or fenfluramine show little in the way of overt ehanges in appearanee or behavior. Dr. Rieaurte (this volume) emphasized the need for more studies in primates, since MPTP-treated miee also show little in the way of observable functional changes, whereas MPTP-treated monkeys show marked neurologie deficits. It may be neeessary to do more detailed analysis of speeifie behaviors and other funetional outputs that are influeneed by dopamine and/or serotonin neurons, to detect functional deficits induced by some neurotoxic drugs. For instance, specific behaviors sueh as appetite-eontrolled behavior (Leibowitz and Shor-Posner 1986), murieidal behavior (Katz 1980), and sexual behavior (Tucker and File 1983) elieited by drugs... 

One of the most sensitive systems affected by lead exposure is the nervous system. Encephalopathy is characterized by symptoms such as coma, seizures, ataxia, apathy, bizarre behavior, and incoordination (CDC 1985). Children are more sensitive to neurological changes. In children, encephalopathy has been associated with PbB levels as low as 70 pg/dL (CDC 1985). The most sensitive peripheral index of neurotoxicity of lead is reported to be slowed conduction in small motor libers of the ulnar nerve in workers with 30-40 pg/dL lead in blood (Landrigan 1989). Other potential biomarkers of lead suggested for neurotoxicity in workers are neurological and behavioral tests, as well as cognitive and visual sensory function tests (Williamson and Teo 1986). However, these tests are not specific to elevated lead exposure... 

It is well accepted that MDMA produces 5-HT depletions in rat CNS, but much less attention has been devoted to the effects of MDMA on established markers of neurotoxicity such as cell death, silver-positive staining, and reactive gliosis. Support for the hypothesis of MDMA-induced axotomy relies heavily on immunohistochemical analysis of 5-HT levels, which could produce misleading results if not validated by other methods. For example, MDMA-induced loss of 5-HT could be due to persistent adaptive changes in gene expression or protein function, reflecting a state of metabolic quiescence rather than neurotoxic damage. Table 7.3 summarizes the effects of MDMA on hallmark measures of neurotoxicity. 

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