Neurological diseases Alzheimer

In vivo experiments have demonstrated that ketones offer neuroprotection in the case of cell culture models of the two most common degenerative neurological diseases, Alzheimer s and Parkinson s and they have also proved that the ketones may offer neuroprotection in the treatment or prevention of both diseases. 

The Complexity of Aluminum-DNA Interactions Relevance to Alzheimer s and Other Neurological Diseases... 

Anitha S, Rao KSJ (2003) The Complexity of Aluminium-DNA Interactions Relevance to Alzheimer s and Other Neurological Diseases 104 79-98 Anthon C, Bendix J, Schaffer CE (2004) Elucidation of Ligand-Field Theory. Reformulation and Revival by Density Functional Theory 107 207-302 Aramburu JA, see Moreno M (2003) 106 127-152... 

The most definitive diagnosis of AD is a postmortem examination of the brain for the presence of two characteristic lesions the neuritic plaque (NP) and the neurofibrillary tangle. Both structures were originally described in 1906 by Alois Alzheimer using silver-based histological stains. The discovery of NPs was hailed as a watershed moment in the history of neurological disease as it helped shift society s perception of age-related dementia from social stigma to physical disease [2]. 

Her case is one of a great many in which some decline in optimal mental function compromises life. These compromises fall into two general categories, whose distinction may be less real than apparent. On the one hand, there are neurological diseases in which there is some detectable, definable lesion in the nervous system. In the last chapter, we met one notable example Alzheimer s disease. As mentioned then, Alzheimer s disease is characterized by amyloid plaques external to neurons and fibrillary tangles within them—clear lesions. On the other hand, there are psychiatric diseases in which the pathology is clear but for which we can detect no lesion in the nervous system. Depression and schizophrenia provide two important examples. 

The cause of Alzheimer s disease is unknown, but genetic factors clearly play a role. One clue supporting this view is provided by the observation that individuals with Down syndrome, a common cause of mental retardation, frequently develop a dementia similar to Alzheimer s disease during early adulthood. Vascular dementia, which is also called multi-infarct dementia, results from the accumulation of tiny strokes. Individually, these strokes or infarcts are too small to cause any noticeable problem, but as they accumulate, they produce deficits similar to Alzheimer s disease. Other neurological diseases such as Parkinson s disease, Pick s disease, and Huntington s disease cause slow deterioration of the brain that ultimately leads to a degenerative dementia. 

Pyroglutamates and their analogues are important compounds in the study and treatment of neurological diseases such as epilepsy, Alzheimer s disease, and... 

Moderately tone to most plants slightly toxic to mammals. Suggested as involved in the etiology of Alzheimer s disease and other neurologic diseases/"... 

Aisen PS, Davis KL, Berg JD, Schafer K, Campbell K, Thomas RG, Weiner MF, Farlow MR, Sano M, Grundman M, Thai LJ. A randomized controlled trial of prednisone in Alzheimer s disease. Alzheimer s Dis Cooperative Study. Neurology 2000 54(3) 588-93. 

Strausak D, Mercer JF, Dieter HH, Stremmel W, Multhaup G. 2001. Copper in disorders with neurological symptoms Alzheimer s, Menkes, and Wilson diseases. Brain Res Bull 55 175-185. 

Diazepin-2-ones, (II), and sulfonyl pyrrolidine derivatives, (III), prepared by Adam (4) and Mutel (5), respectively, were effective as glutamate receptor antagonists and used in treating neurological diseases such as Alzheimer s disease and psychotic and schizophrenic disorders. 

Figure 14.3 Plot of CSF Api -38 relative concentration ratio vertical axis, Apt-38%) and CSF Apt-42 relative concentration ratio (horizontal axis, Apt -42%). Cases of Alzheimer s diseases (AD), nondementive neurologic diseases (OND), and chronic neuroinflammatory diseases (CID) have been investigated. With an Api-42% discriminatory...

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