Neuroendocrine adenomas

Middle ear adenomas (MEAs, also known as carcinoid tumors and neuroendocrine adenomas) are distinctly uncommon tumors that affect both sexes equally and occur over a broad age range (14 to 80 years) with an average of about 40 to 45 years. > The most common complaints are unilateral hearing loss, tinnitus, and fullness in the ear. Otorrhea and pain are uncommon. On imaging, the tumor is always extraosseous with no evidence of bone destruction. 

Many of the tumors of the nasal cavity and paranasal sinuses fall under the category of round cell neoplasms. Among these are olfactory neuroblastoma, sinonasal undifferentiated carcinoma, malignant melanoma, neuroendocrine carcinoma-small cell neuroendocrine carcinoma, malignant lymphoma, extramedullary plasmacytoma, invasive-ectopic pituitary adenoma, rhabdomyosarcoma, and Ewing s sarcoma (ES)-peripheral neuroectodermal tumor (ES/ PNET). But there is also a host of other epithelial lesions that are unique to the sinonasal tract. 

Chromogranin A/Dr. Lloyd/1 160 Pituitary adenoma paraganglioma neuroendocrine tumors Mw 1 5 min in citrate, pH 6.0... 

Solitary fibrous tumor, synovial sarcoma, hepatic adenoma, neuroendocrine carcinoma, GIT adenocarcinomas, endometrioid carcinoma, cholangiocellular carcinoma... 

Neuroendocrine tumors pituitary adenomas, medullary thyroid carcinoma, pheochromocytoma, islet cell... 

Synaptophysin Neuroendocrine tumors pituitary adenomas, medullary thyroid carcinoma, pheochromocytoma, islet cell tumors, small cell carcinoma, carcinoid and neuroendocrine Medulloblastoma, retinoblastoma, neurocytoma, ependymoma, neuroblastoma, adrenocortical tumors. Merkel cell tumors Neuronal and neuroendocrine cells, carotid body cells, adrenal cortex and medulla... 

Protein isoforms result from protein PTMs, splicing, etc. Our comparative proteomics study of human pituitary adenomas demonstrated that human pituitary hormones had multiple isoforms. The change of a neuroendocrine hormone level is an important clinical feature in a human pituitary adenoma. Not all of the isoforms are related to pituitary adenomas [32]. 

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