Nerve growth factor promoter

Hefti, F. (1986). Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transactions. J. Neurosci. 6(8), 2155-2162. 

Kawaja, M. D., Rosenberg, M. B., Yoshida, K., and Gage, F. H., Somatic gene transfer of nerve growth factor promotes the survival of axotomized septal neurons and the regeneration of their axons in adult rats, J. Neurosci., 12, 2849, 1992. 

Winn, S. R., Hammang, J. P., Emerich, D. F., Lee, A., Palmiter, R. D., and Baetge, E. E., Polymer-encapsulated cells genetically modified to secrete human nerve growth factor promote the survival of axotomized septal cholinergic neurons, Proc. Natl. Acad. Sci. U.S.A., 91, 2324, 1994. 

Oudega, M. and Hagg, T., Nerve growth factor promotes regeneration of sensory axons into adult rat spinal cord, Exp. Neurol., 140, 218, 1996. 

Clos, J. and Legrand, C. (1990) An interaction between thyroid hormone and nerve growth factor promotes the development of hippocampus, olfactory bulbs and cerebellum a comparative biochemical study of normal and hypothyroid rats. Growth Factors 3 205-220. 

Martinez, H.J., Dreyfus, C.F., Jonakait, G.M. and Black, 1. (1985) Nerve growth factor promotes cholinergic development in brain striatal cultures. Proc. Natl. Acad. Sci. USA 82 7777-7781. 

Neuronal survival and differentiation are regulated by many factors including neurotrophins and the Trk family of RPTKs. The prototype neurotrophin, nerve growth factor (NGF), promotes the survival of neurons during a period of programmed cell death in embryonic and early postnatal developmental stages. It is a target-derived neurotrophic factor that modulates the functions of the... 

Takahara. Extraction of nerve growth factor biosynthesis promoters from tobacco. Patent-Japan Kokai Tokkyo Koho-04 210,643 1992 5 pp. 

Abbreviations IR inverted repeat DR direct repeat ER everted repeat NR no repeat . Numbers of the HREs give the number of pairs separating the half-sites. R purine, Y pyrimidine. NGFI Nerve growth factor induced receptor COLfP-TF Chicken ovalbumin upstream promoter transcription factor ROR Retinoic acid related orphan receptor, a, P und y are receptor subtypes coded by distinct genes. After Mangelsdorf et al., 1995. 

Figure 30-7 Effect of one ng of nerve growth factor in promoting the production of neurites in a chick embryonic sensory ganglion. From Frazier et al.255...

Another conceivable therapeutic approach for Alzheimer s disease could be based on the administration of neurotrophic factors. Nerve growth factor (NGF) is a 118 amino acid polypeptide with no blood-brain barrier penetrance. Other substances with neurotrophic activity such as epidermal growth factor, brain-derived neurotrophic factor, gangliosides, and the (11-28 peptide of the b-amyloid protein might also have a therapeutic potential. Intracerebroventricular (ICV) administration of NGF has been shown to partially reverse lesion-induced deficits of cortical AChE and choline acetyltransferase (CHAT) activities to promote survival of septal cholinergic neurons after fimbrial transection in adult rats and to reverse behavioral deterioration in rats with such lesions. 

Nerve growth factor Animal Stanley Gohen (USA, NGF-KFK agonist [promotes... 

Nerve growth factor (NGF) Cystine knot motif Promotes cell death in the nervous system, when bound to p75l t Two types of receptor, co-receptor NGFR-a,P p75NGFR, have no tyrosine kinase activity. They are cytokine-type receptors like the TNF-receptor... 

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