Human nerve growth factor

M. Eng, V. Ling, J. A. Briggs, K. Souza, E. Canova-Davis, M. F. Powell, L. R. De Young, Formulation Development and Primary Degradation Pathways for Recombinant Human Nerve Growth Factor , Anal. Chem. 1997, 69, 4184-4190. 

Initial studies by CytoTherapeutics, Inc. (later StemCells, Inc.), which led to the development of HuCNS-SC, focused on the delivery of protein neurotrophic factors into the neural system. In particular, studies focused on the transfer of human nerve growth factor (NGF) into neurodegenerative animal models [199982], [199983], [225755], [243560],... 

Polymer-encapsulated genetically modified cells continue to secrete human nerve growth factor for over one year in rat ventricles Behavioral and anatomical consequences. Winn, S.R., Lindner, M.D., Lee, A., Haggett, G., Francis, J.M., Emerich, D.F. (1996). Exp Neurol, 140 (2) 126-138. 

Tuszynski, M. H. et al. (1991). Recombinant human nerve growth factor infusions prevent cholinergic neuronal degeneration in the adult primate brain. Ann. Neurol. 30(5), 625-636. 

Nguyen B, Jarnagin K, Williams S, Chan H, Barnett J (1993), Fed-batch culture of insect cells a method to increase the yield of recombinant human nerve growth factor (rhNGF) in the baculovirus expression system, J. Biotechnol. 31 205-217. 

Binkley J, Allen P, Brown DM, Green L, Tuerk C, Gold L, RNA ligands to human nerve growth factor, Nucleic Acids Res., 23 3198-3205, 1995. 

Hardy L, Ortega S, Rogers B, Sinicropi D, Clarke J, Oneda S. Recombinant human nerve growth factor is not teratogenic when administered subcutaneously to cynomolgus monkeys. Toxicologist 1998 42(1-S) 259. 

Knepp, V. M., Whatley, J. L., Muchnik, A., and Calderwood,T. S. (1996), Identification of antioxidants for prevention of peroxide-mediated oxidation of recombinant human ciliary neurotrophic factor and recombinant human nerve growth factor, J. Parenteral Sci. Technol., 50,163-171. 

ViUoslada P, Hauser SL, Bartke I, Unger J, Heald N, Rosenberg D, Cheung SW, Mobley WC, Fisher S, Genain CP (2000) Human nerve growth factor protects common marmosets against autoimmune encephalomyelitis by switching the balance of T helper ceU type 1 and 2 cytokines within the central nervous system. J Exp Med 191 1799-1806. 

Winn, S. R., Hammang, J. P., Emerich, D. F., Lee, A., Palmiter, R. D., and Baetge, E. E., Polymer-encapsulated cells genetically modified to secrete human nerve growth factor promote the survival of axotomized septal cholinergic neurons, Proc. Natl. Acad. Sci. U.S.A., 91, 2324, 1994. 

Emerich DF, Hammang JP, Baetge EE, Winn SR. Implantation of polymer-encapsulated human nerve growth factor- secreting fibroblasts attenuates the behavioral and neuro-pathological consequences of quinolinic acid injections into rodent striatum. Exp Neurol 1994 130 141-150. 

Kordower JH, Winn SR, Liu YT, et al. The aged monkey basal forebrain rescue and sprouting of axotomized basal forebrain neurons after grafts of encapsulated cells secreting human nerve growth factor. Proc Natl Acad Sci USA 1994 91 10,898-10,902. 

Petty, B.G., et al., The effect of systemically administered recombinant human nerve growth factor in healthy human subjects. Annals of Neurology, 1994, 36(2), 244-246. 

Apfel S C, Kessler J A, Adornato B T, et al. (1998). Recombinant human nerve growth factor in the treatment of diabetic polyneuropathy. NGF Study Group. Neurol. 51 695-702. 

Dyck P J, Peroutka S, Rask C, et al. (1997). Intradermal recombinant human nerve growth factor induces pressure allodynia and lowered heat-pain threshold in humans. Neurol. 48 501-505. 

Apfel SC, Schwartz S, Adomato BT et al. Efficacy and safety of recombinant human nerve growth factor in patients with diabetic polyneuropathy A randomized controlled trial. rhNGF Clinical Investigator Group. JAMA 2000 284(17) 2215-21. 

Human nerve growth factor Aggregation and loss of biological activity during release (22,27)... 

Sehgal A, Wall DA, Chao MV. 1988. Efficient processing and expression of human nerve growth factor receptors in Xenopnis laevis oocytes effects on maturation. Mol Cell Biol 8(5) 2242-2246. 

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