Visceral hyperalgesia

Farquhar-Smith WP, Jaggar SI, Rice ASC (2002) Attenuation of nerve growth factor-induced visceral hyperalgesia via cannabinoid CBl and CB2-like receptors. Pain 97 11-21... 

The antinociceptive effect of CGRP(8-37) was observed in different pain types of such as abdominal pain (p-phenylquinone induced writhing, Saxen et al., 1994 acetic acid-induced writhing, Friese et al., 1997), visceral pain (colorectal distension model, Plourde et al., 1997), burn pain (heat-induced hyperalgesia Lofgren etal., 1997), and... 

Animal models of nociception can be divided according to the therapeutic indication Acute Pain, Migraine Pain, Inflammatory Pain, Visceral Pain, Neuropathic Pain. Different degrees of chronification (up to weeks in neuropathic pain models) and different stimuli (mechanical, thermal, chemical, electrical) are used depending on the experimental question. In most cases a nociceptive threshold (e g. withdrawal latency of a paw) is determined. Sometimes, nociceptive intensities are determined e.g. in order to quantify hyperalgesia. 

Tang B, Ji Y, Traub RJ (2008) Estrogen alters spinal NMDA receptor activity via a PKA signaling pathway in a visceral pain model in the rat. Pain 137 540-549 Tao F, Tao YX, Zhao C, E>ore S, liaw WJ, Raja SN, Johns RA (2004) Differential roles of neurontil and endothelial nitric oxide synthases during carrageentm-induced infleunmatory hyperalgesia. Neuroscience 128 421-430... 

Laird JMA, Souslova V, Wood JN, Cervero F (2002) Deficits in visceral pain and referred hyperalgesia in Navl.8 (SNS/PN3)-null mice. J Neurosci 22 8352-8356 Lalloo UG, Fox AJ, Belvisi MG, Chung KF, Barnes PJ (1995) Capsazepine inhibits cough induced by capsaicin and citric acid but not by hypertonic saline in guinea pigs. J Appl Physiol 79 1082-1087... 

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