Neoplasm inhibitor

The cyclopropylcarbinol nucleosides 172-177 have also been prepared and tested as antiviral, antitumoral, antibacterial agents and neoplasm inhibitors, Eq.68) [230-232]. 

Compounds 5 are used as neoplasm inhibitors (89EGP270711) and 14 as vasodilators, anticholesteremics, and blood platelet aggregation inhibitors [81JAP(K)81/127383]. Significant activity against histamine-induced bron-... 

V-bromosuccinimide, bromination with, 77 Nematocide, 136, 440 Neoplasm inhibitor, 148 Nervous system action, 138... 

Morinaga (6) observed that the stilbene derivative (Z)-l-(3-(2-amino-3-hydroxypropamidc)-4-mcthoxyphcnyl)-2-(3,4,5-trimethoxyphenyl)cthanc, (VI), in conjunction with the neoplasm inhibitor Cisplatin , (NH3)2Cl2Pt(II), strongly inhibited mitosis without patient weight loss associated with other antitumor agents such as Vindesine . 

Some urdamycin B-type antibiotics, isolated from Streptomyces BA-12100, have also been patented as neoplasm inhibitors [168], Structures 233 are (on purpose ) ambiguously drawn, and several alternatives remain (stereochemistry, R, R ), which may be due to an error in the drawing of the structures. 

Hoefle, G., Reichenbach, H., Sasse, F., and Steinmetz, H. (1993). Archazolide A, its manufacture with Archangium gephyra, and its use as neoplasm inhibitor and fungicide. German Patent. 4142951. 

Related compounds such as the cw-Pt-linked phosphonate 41 showed high anticancer effects, as evidenced by a standstill of tumour growth after 3 weeks of therapy in intraosseously transplanted osteosarcoma in rats, and an increase in life span. Compound 41 at 0.346 and 0.6 mmol kg total dose was very effective. Aminoacyl diphosphonates have been prepared as neoplasm inhibitors. A-( 4-[Bis(2-chloroethyl)amino]phenyl-alanyl alanyl)-4-amino-l-hydroxybutane-l,l-diphosphonic acid hydrochloride (42) has been found to be active against murine leukaemia L-1210, ID50 0.1 pg ml (ref. 87). 

W. E. G. Muller, H. C. Schroder Synergistic neoplasm inhibitors comprising avarone derivatives and 3 -deoxy-3 -flurothymidine, Ger. Offen., DE 3939701 Al, 6th June 1991. 

Wright, A.E. McCarthy, P. Cross, S.S. Rake, J.B. McConnel, O.J. Sesquiterpenoid Isocyanide Purification from a Marine Sponge and Its Use As a Neoplasm Inhibitor, Virucide and Fungicide. 1988. European Patent Application EP 285,302, October 5, 1988 U.S. Patent Application 32,289, March 30, 1987. CAN lll 50414u. 

The photochemical activity (phototoxicity) of several psoralen derivatives has potential appU-cation in several areas. Biotin derviative (340), for example, is a neoplasm inhibitor it inhibited the growth of lymphocytes by 99% in the presence of near UV light <87MIP8705805). Compounds (341) and (342) both displayed photochemical antibacterial activity <87Mi 208-04). Benzopsoralen (343) is a DNA photoreagent <86JHCI405). 

Another Radioimmunoassay method was reported for vinblastine and vincristine as follows ( 129) Radioimmunoassay developed for determining the neoplasm inhibitors vinblastine (I) and vincristine (II) in blood involves the use of antiserum raised in a rabbit immunized with (I) bovine... 

Berscheid HG, Boettger D, Kraemer HP (1987) Preparation of anthracycline tetrasac-charides as neoplasm inhibitors. EP Patent 207463 (Chem Abstr 107 176411)... 

Bourzat JD, Commer on A, Guenard D, Gueritte-Voegelein F, Potier P (1993) Preparation of 0-Carbamoyl Taxol Analogs as Neoplasm Inhibitors, Eur Pat Appl Ep 524,093 (Cl. C007D305/14)FR Appl 91/8, 937,16 Jul 1991... 

The neoplasm inhibitors, isomitomycin A (52) and albomitomycin A (54) and (56), were isolated, together with mitomycin A from S. caespitosus culture broth. Both antibiotics were obtained by intramolecular rearrangement of mitomycin A [76]. Anticancer antibiotics AX-2 (53) and CX-1 (55) were isolated from the culture broth of S. caespitosus and obtained from mitomycin C [77]. Other biological activities of different mitomycines, their mechanisms of action, and therapeutic utility have been described in various reviews [5, 9, 77-83]. 

Several derivatives (71-76) of amide aziridme-2-carboxyIic acid (also known as leacadine, 71) were prepared as neoplasm inhibitors [102], Leacadine has been used for treatment of multiple sclerosis [103], The antitumor efficacy of azimexon (72) in experimental animals and humans was described with respect to its various inunu-nological parameters [104]. Two synthetic aziridine-2-carboxyhc acid (2) (71 and 76) showed antitumor activity against a mammary gland tumor in rats [105],... 

Several bioactive phospholipids (91-96) have been synthesized. Putative neoplasm inhibitors (91-94) showed significant activities in the Walker carcinosarcoma 256 and leukemia L1210 assay systems [117]. The low-melting cytotoxic phospholipids with aziridine groups (95 and 96) capable of forming stable dispersions in aquatic glycerol solutions containing 1% egg lecithin were prepared [118]. 

Neoplasm inhibitors at C-4 aziridine-bearing paclitaxel (taxol) analogues (134-136) were synthesized. The key step in the synthesis is the aziridine ring formation at the C-4 position via an intramolecular Mitsunobu reaction [139]. Biological activity of paclitaxel analogues is shown in Table 30.6. 

Ito T, Hsuan CP, Chang HH 1981 Saponins as neoplasm inhibitors. Japanese Patent Kokai Tokkyo Koho 81 46,817... 

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