Archangium gephyra

Difficidin (Fig. 15, 82) is a 22-membered ring triene macrolide with a phosphate ester produced by Bacillus subtilis [104]. It showed broad activity against aerobic and anaerobic bacteria. Archazolide A (83) is a 24-membered ring triene macrolide isolated from a myxobacterium, Archangium gephyra [105]. 

Hoefle, G., Reichenbach, H., Sasse, F., and Steinmetz, H. (1993). Archazolide A, its manufacture with Archangium gephyra, and its use as neoplasm inhibitor and fungicide. German Patent. 4142951. 

Tubulyshis, Tetrapeptides from fermentation cultures of Archangium gephyra with antimycotic and cytostatic activity. T. A-D inhibit the growth of certain tumor cell lines very potently (e.g., KB 3.1 cervix, PC-3 prostata, SK-OV3 ovarials, K-562 leukemia) with IC50 values between 1 and 200 pg/mL (mechanism induc-... 

Prod, by Archangium gephyra. Antifungal and antineoplastic agent. 

Hofle et al. [88] first isolated archazolide 111 from the myxobacterium Archangium gephyra. This compound exhibited potent growth-inhibitory activity against a number of murine and human cancer cell lines, based on selective inhibition of vacuolar-type ATPases, in vitro and in vivo. It comprises unique structure with a polyunsaturated 24-membered macrolactone, with eight stereogenic centers and a pendant thiazole side chain at C23. 

Archangium gephyra (bacterium strain Ar T205) (182) Myxococcus virescens (bacterium strain Mx v48) (182) Archangium gephyra (bacterium strain Ar T205) (182)... 

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