Neely

Wu, C.S. Neely, W.C. Worley, S.D. A Semiempirical Theoretical Study of the Molecular Interaction of Cocaine with the Biological Substrate Glycine. 7 Comput. Chem. 12 862-867, 1991. 

Neely WB. The use of molecular orbital calculations as an aid to correlate the structure and activity of cholinesterase inhibitors. Mol Pharmacol 1965 1 137-44. 

Experimentally measured bioconcentration factors (BCFs), which provide an indication of the tendency of a chemical to partition to the fatty tissue of organisms, have been found to range between 10 and 100 for trichloroethylene in fish (Kawasaki 1980 Kenaga 1980 Neely et al. 1974 Veith et al. 1980). Barrows et al. (1980) estimated a value of 17 for bluegill sunfish. Somewhat lower BCFs were determined by Saisho et al. (1994) for blue mussel (4.52) and killifish (2.71). These numbers are suggestive of a low tendency to bioaccumulate. 

Neely WB, Branson DR, Blau GE. 1974. Partition coefficients to measure bioconcentration potential of organic chemicals in fish. Environmental Science and Technology 8 1113-1115. 

J. H. Neely and E. C. Isacoff, "Cart>onaceous Adsorbents for the Treatment of Ground and Surface Haters", Dekker, New York, NY, 1982. 

In addition to dissipation of the substance from the model system through degradation, other dissipative mechanisms can be considered. Neely and Mackay(26) and Mackay(3) have also introduced advection (loss of the chemical from the troposphere via diffusion) and sedimentation (loss of the chemical from dynamic regions of the system by movement deep into sedimentation layers). Both of these mechanisms are then assumed to act in the unit world. This approach makes it possible to investigate the behavior of atmosphere emissions where advection can be a significant process. Therefore, from a regulatory standpoint if the emission rate exceeds the advection rate and degradation processes in a system, accumulation of material could be expected. Based on such an analysis reduction of emissions would be called for. 

Neely, W. B. Mackay, D. 1981, presented at workshop "Modeling the Fate of.Chemicals in the Aquatic Environment", Pell-ston, Michigan. 

A very significant advance was made by Baughman and Lassiter (5) when they suggested using evaluative environments for elucidation of the environmental behavior of chemicals. This led to the EXAMS model (6), the studies of selected chemicals by Smith et al (7, 8), the development of "Unit Worlds" by Neely and Mackay (9) and Mackay and Paterson (2), and the incorporation of similar Unit Worlds into hazard assessment by Schmidt-Bleek et al (10). 

The QUASI fugacity model was then run for a trichlorobiphenyl in a lake the size of Lake Michigan, being approximately 60,000 times the size of the evaluative environment. A detailed justification for the selection of D values is beyond our scope here but in selecting values, we have relied on recent reports by Neely (11), Rogers (15), Armstrong and Swackhamer (16), Thomann (17), and Andren (18). 

Neely, W. B. Mackay, D. "An Evaluative Model for Estimating Environmental Concentrations", in "Modelling the Fate of Chemicals in the Aquatic Environment", editors, Dickson, K.L. Maki, A. W. and Cairns, J., Jr., Ann Arbor Science, Ann Arbor 1982, 127-143. 

Marsh D, Neely J, Breazeale D et al. Linkage analysis of IL4 and other chromosome 5q31.1 markers and total semm immunoglobin E concentrations. Science 1994 264 1152-1156. 

Neely, K.E. et al. (2002) Transcription activator interactions with multiple SWI/SNF subunits. Mol. Cell. Biol. 22(6), 1615-1625. 

Correlation with Kow (Neely et al. 1974, Konemann and van Leeuwen 1980, Veith et al. 1980, Chiou et al. 1977, Mackay 1982, Briggs 1981, Garten and Trabalka 1983, Davies and Dobbs 1984, Zaroogian et al. 1985, Oliver and Niimi 1988, Isnard and Lambert 1988) ... 

Mill, T., Mabey, W. (1985) Photochemical transformations. In Environmental Exposure from Chemicals. Vol. I, Neely, W.B., Blau, G.E., Eds., Chap. 8, pp. 175-216. CRC Press, Boca Raton, Florida. 

Mackay, D., Paterson, S., Chung, B., Neely, W.B. (1985) Evaluation of the environmental behavior of chemicals with a level III fugacity model. Chemosphere 14, 335-374. 

Neely, W.B. (1980) A method for selecting the most appropriate environmental experiments on a new chemical. In Dynamics, Exposure and Hazard Assessment of Toxic Chemicals. Haque, R., Ed., pp. 287-298, Ann Arbor Sci. Publ., Ann Arbor, MI. 

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