Nedocromil

Cromones are used to prevent asthma attacks. To be effective they have to betaken continuously. Their mechanism of action is poorly understood. Cromones (cromolyn sodium, nedocromil) act as mast cell-stabilizing agents,... 

Both disodium cromoglycate and nedocromil sodium have antitussive effects in humans. In this instance, their activity occurs by increasing the depolarisation of sensory nerves, which increases the threshold for an action potential and therefore inhibits the activity of these neurons. 

Mast cell stabilizers include cromolyn sodium (Intal) and nedocromil sodium (Tilade). 

The mast cell stabilizers currently for ophthalmic use are nedocromil and pemirolast. These drugp are used for the prevention of eye itching caused by allergic conjunctivitis. The mast cell stabilizers act by inhibiting the antigen-induced release of inflammatory mediators (eg, histamine) from human mast cells. 

NCF Neutrophil chemotactic factor NDGA Nordihydroguaretic acid NDP Nucleoside diphosphate Neca 5 -(N-ethyl carboxamido)-adenosine NED Nedocromil sodium NEP Neutral endopeptidase (EC 3.4.24.11)... 

Exacerbations nedocromil OR sustained-release Alternative Treatment... 

In persistent asthma, inhaled corticosteroids provide the most comprehensive control of the inflammatory process and are the cornerstone of therapy.2 Inhaled corticosteroids are more effective than cromolyn, leukotriene modifiers, nedocromil, and theophylline in reducing markers of inflammation and AHR, improving lung function, and preventing emergency department visits and hospitalizations due to asthma exacerbations.2,25 The primary... 

Cromolyn and nedocromil are inhaled anti-inflammatory agents that block both the early- and late-phase response. Both agents are considered alternative therapies to inhaled corticosteroids for the treatment of mild persistent asthma however, both are less effective than low doses of inhaled corticosteroids.2,30 The exact mechanism of action of these agents is not understood, but they appear to inhibit mast cell mediator release as well as modulate other inflammatory responses.3... 

Patients receiving these agents may notice improvement in 1 to 2 weeks, but maximal benefit may not be seen for 4 to 6 weeks. Cromolyn and nedocromil appear to be similar in efficacy to the leukotriene antagonists and theophylline for persistent asthma.18 Both agents are well tolerated with adverse effects limited to cough and wheezing. Bad taste and headache have also been reported with nedocromil. One dose of cromolyn or nedocromil prior to exercise or allergen exposure will provide effective prophylaxis for 1 to 2 hours. Cromolyn and nedocromil are not as effective as albuterol for prophylaxis of exercise-induced asthma. 

In patients with mild intermittent asthma, long-term control medications are not necessary, and patients should use a short-acting inhaled P2-agonist t° prevent or treat symptoms.2 This classification includes patients with exercise-induced asthma, seasonal asthma, or asthma symptoms associated with infrequent trigger exposure. Patients can pre-treat with two puffs of cromolyn or nedocromil prior to exposure to a known trigger. The treatment of choice for exercise-induced asthma is two inhalations of albuterol 5 minutes prior to exercise.1 Cromolyn and nedocromil are less effective than albuterol for prophylaxis of exercise-induced asthma. 

Nedocromil, a mast cell stabilizer, has not been adequately tested in COPD patients and is not included in the GOLD recommendations. 

Nedocromil Mast cell stabilizer, Hrreceptor antagonist May inhibit eosinophils... 

Nedocromil 1-2 drops in each eye twice daily Ocular stinging, bitter taste... 

MJ Clarke, MJ Tobyn, TN Staniforth. Physicochemical factors governing the performance of nedocromil sodium as a dry powder aerosol. J Pharm Sci 89(9) 11601-1169, 2000. 

In the crystalline state of a substance, the molecules are arranged in a defined unit cell that is repeated in a three-dimensional lattice [1], Since the crystal lattice can act as a diffraction grating for X-rays, the X-ray diffraction pattern of a crystal consists of a number of sharp lines or peaks, often with baseline separation. Figure 1 shows the X-ray powder diffraction pattern of the crystalline and amorphous forms of nedocromil sodium trihydrate. 

Figure 1 X-ray powder diffractograms of the crystalline and amorphous forms of nedocromil sodium trihydrate. I is the intensity of the diffracted beam at a diffraction angle 9. (RK Khankari and DJW Grant, unpublished observations.)...

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