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Natural scaffolds

The development of predictive transition state models for the interpretation of selectivity data pertaining to the use of cinchona alkaloid derivatives in all the processes described above is challenging due to the complex conformational behaviour of these natural scaffolds (for example, it is well known that 0-acylated quinidines undergo major conformational changes upon protonation) [223]. Consequently, hypotheses regarding the details of chirality transfer in these systems are notably absent. [Pg.272]

Glycerol (propane-1,2,3-triol) is a very important structural part of the phospholipids, the major components of natural membrane bilayers. Based on this natural scaffold, diesters of glycerol and of related derivatives have been extensively used for the construction of synthetic building blocks carrying vicinal lipid chains (for examples, see Scheme 14). [Pg.363]

The last topic in evaluating the suitability of reticulated foam as the scaffold of a composite is somewhat qualitative. It is known that hepatic cells do not function when cultured on a flat plate. At least part of the reason for this is the deformation of the cells developed during the spreading process. It seems likely that if a cell is sufficiently deactivated by a flat surface, the effect will be as severe as when culturing on a convex surface such as the outside shape of a hollow fiber. A reticulated foam, however, presents a cell with several opportunities for a more natural attachment. The dodecahedron structure of each foam cell would appear to be a more natural scaffold for attachment. This perhaps explains the claimed superiority of a scaffold based on a reticulated foam of Gion et al. - over the HepatAssist hollow fiber device. Part of the research program that we will propose is that the effects of conformational aspects of an efficient scaffold will be quantified. [Pg.160]

A specific class of libraries in which biologically active natural products are either built during the synthesis or used as scaffolds to be decorated has recently emerged and has gained considerable attention for pharmaceutical purposes. The biological information contained in the natural scaffold increases the chances of discovering novel active structures. Some examples depicted in Figs. 4.14-4.18 demonstrate the potential of natural product libraries. [Pg.152]

A more complex combinatorial strategy based on a natural scaffold was reported by Nicolaou et al. (56) with the synthesis of an epothilone-based SP library L27 (Fig. 4.18). This biased library was prepared asa3x3x5 = 45-member collection, but the final reaction vessels could, theoretically contain 4 different isomeric desoxyepothi-lones (Fig. 4.18), thus leading to a total number of 45 x 4 = 180 components. The library was prepared using a radiofrequency encoding technique (42), and the final... [Pg.155]

Rapid biofabrication of tubular tissue construct by centrifugal casting in a decellularized natural scaffold with laser-machined icropores , J Mater Sci Mater Med, 20, 329-37. [Pg.19]

The use of supramolecular hydrogels in regenerative medicine is inspired by the extracellular matrix (ECM), which provides the natural scaffolding for cells inside the body [14]. Mimicking the ECM is a major objective for tissue engineering, in order to create a regenerating niche for cells [15]. The natural ECM is inherently... [Pg.254]

Besides the use of novel fiinctionahty that is beyond rational design by synthetic chemists, nature is unsurpassed at the display of chemical information in three-dimensional space. For example, despite intensive efforts, there is no standard algorithm for translating a linear peptide into a small-molecule peptidomimetic. Meanwhile, numerous natural scaffolds perform this task efficiently, as in the opium alkaloids conformational mimicry of the enkephaUns. We will never know what revolutionary new scaffolds and pharmacophores will be lost if natural product screening is discontinued. [Pg.43]

The availability of strains and an appropriate technical infrastructure are the prerequisites for the production of natural scaffolds in amounts necessary for library synthesis. For our in-house scaffold selection, we screen subfractions and compounds that originate from our own highly diverse microbial strain collection, containing more than 45,000 actinomycetes and 8,(X)0 fungi. If scaffolds are identified from literature or database mining, it may be difficult to acquire the producing strain. [Pg.106]

The rich structural diversity and complexity of natural products have inspired chemists and pharmacologists since the beginning of the pharmaceutical industry. Even today, many drugs are natural products or natural product derivatives. Natural scaffolds, meticulously assembled in the molecular... [Pg.123]

Differences in the fluorescent intensities upon induction of conformational changes are observed in the case of fluorescently labeled biopolymers such as protein or DNA, though these scaffolds have not been extensively used so far for the synthesis of enantioselective luminescent sensors. An advantage of using these natural scaffolds is that high enantiomeric recognition is one of their intrinsic properties [141]. [Pg.199]

In fact the transition from bench to market of combination products is often hindered by a series of scientific and economic issues. Both the determination of the ideal cell type and the ideal biomaterial for the specific application can be problematic. Often, the use of autologous differentiated cells would be the best solution, but their use may not be feasible because of limitation on isolation and expansion. Moreover, the use of autologous cells also can introduce infections risks deriving from the use of xenogenic factors or animal feeder layers in culture. Hopefully, adult and embryonic stem cells may provide alternative solutions. Also the determination of the most suitable biomaterial for the specific application is a challenge. Most of the currently available synthetic materials are subjected to a foreign body reaction that can lead to serious complications when implanted in the human body. The use of natural scaffolds circumvents this problem, but it introduces other drawbacks such as inappropriate mechanical properties. Smart combinations of synthetic scaffolds modified with natural... [Pg.384]

By using these types of bioactive materials, scientists may be able to capture the advantages of a natural scaffold, such as specific cell-material interactions and proteolytic remodehng in response to tissue formation, and take advantage of the benefits of a synthetic material, namely the ease of processing and the ability to manipulate mechanical properties. [Pg.59]

Synthetic Scaffolds Natural Scaffolds Cell Assembly Matrix... [Pg.689]

Hulme and coworkers applied Armstrong s isocyanide to synthesize another natural scaffold DKP 131 in a solution phase (Scheme 7.40) in good yield [58]. [Pg.139]


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See also in sourсe #XX -- [ Pg.378 ]




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Scaffolding natural biopolymers

Scaffolds natural product-like

Scaffolds natural products

The scaffold tree for structural classification of natural products

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