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Naproxen Alcohol

Most of the reactions applied to amines can also be transferred to alcohols (Eig. 7-5). One large group of chiral alcohols are the (i-adrenoreceptor blockers, for which a variety of derivatization agents was developed. One highly versatile reagent for the separation of (i-blockers is A-[(2-isothiocyanato)cyclohexyl]3,5-dinitrobenzoyl-amide (DDITC) [11]. Alternatively, unichiral drugs such as (3-blockers or (S)-naproxen [12] may be used in a reciprocal approach to derivatize racemic amine compounds. [Pg.189]

A 25-year-old Caucasian woman presents to the university student clinic with complaints of intermittent crampy abdominal pain and four to five loose stools per day. She describes some visible mucus and blood in the stool and states that these symptoms have been present for 6 to 8 weeks. She also has intermittent lower back pain, fatigue, fever, and a 10-lb (4.5 kg) weight loss. The back pain started about the same time as her gastrointestinal symptoms. She denies any sick contacts and has not eaten any take-out or restaurant food over the last 2 months. She takes nonprescription naproxen as needed for aches and pains. She has been using more naproxen recently because of the back pain. She also takes an oral contraceptive pill once daily. She consumes alcohol socially and currently smokes 1/2 to 1 pack of cigarettes per day. [Pg.285]

Acetaminophen is recommended by the ACR as first-line drug therapy for pain management of OA. The dose is 325 to 650 mg every 4 to 6 hours on a scheduled basis (maximum dose 4 g/day maximum 2 g/day if chronic alcohol intake or underlying liver disease). Comparable relief of mild to moderate OA pain has been demonstrated for acetaminophen (2.6 to 4 g/ day) compared with aspirin (650 mg four times daily), ibuprofen (1,200 or 2,400 mg daily), and naproxen (750 mg daily). However, some patients respond better to NSAIDs. [Pg.25]

With a rhodium complex catalyst containing a chiral ligand dispersed in [BMIM]SbFg, the enantioselective hydrogenation of a-acetamidocinnamic acid to (5)-phenylalanine was achieved with 64% enantiomeric excess 112). [RuCl2( S)-BINAP]2 NEt3 in [BMIM]BF4 for (5)-naproxen synthesis gave 80% ee from 2-(6-methoxy-2-naphthyl) acrylic acid and isopropyl alcohol 214). [Pg.206]

Aspirin, 325-650 mg every 4-6 hours Bayer Aspirin, Ecotrin, Bufferin, various generic children who cannot chew or swallow tablets. Do not exceed a total daily acetaminophen dose of 4 g (2 g/d in regular alcohol users). Aspirin should be used cautiously in certain individuals (see text). Use of OTC products containing aspirin, other salicylates, acetaminophen, ibuprofen, or naproxen may increase the risk of hepatotoxicity and gastrointestinal hemorrhage in individuals who consume 3 or more alcoholic drinks daily. Long-term continuous use of NSAIDs may increase the risk of heart attack or stroke. [Pg.1343]

Several commercial products have been produced via Heck reactions on a scale in excess of one ton year"1 [43]. The sunscreen agent 2-ethylhexyl-p-methoxycinna-mate has been synthesized on a pilot scale by using Pd/C as the catalyst [44]. Albermarle produces Naproxen via a Heck reaction of 2-bromo-6-methoxy-naphthalene with ethylene, followed by carbonylation of the product [45]. A key step in the production of Singulair (montelukast sodium), a leukotriene receptor antagonist for treatment of asthma, is Heck reaction of methyl 2-iodobenzoate with an allylic alcohol to give a ketone [43]. [Pg.286]

BINAP-ruthenium(II) is particularly good at catalysing the hydrogenation of allylic alcohols, and of a,(3-umaturated carboxylic adds to give acids bearing a stereogenic centres (like naproxen above). [Pg.1236]

In another trial the pharmacokinetics of a single dose of naproxen was studied in 11 patients with liver disease (four severe hepatitis with cholestasis two extrahepatic cholestasis one chronic alcoholic cirrhosis two active chronic hepatitis, with and without symptoms one asymptomatic PBC and one asymptomatic hepatic cirrhosis). In two of the seven patients with cholestasis, a significant delay in absorption occurred. In most of the patients studied there was a significant decrease in elimination, increasing the half-life from around 14 hours to 20 hours [41]. [Pg.186]

Williams RL, Upton RA, Cello JP, et al. (1984) Naproxen disposition in patients with alcoholic cirrhosis. Eur J Clin Pharmacol 27 291-296. [Pg.209]

The AGP CSP can be used with a wide range of cationic and anionic compounds. The cationic compounds include relatively simple molecules such as methylphenidate, tetrahydroxoline, and terbutaline a,p-amino alcohols such as ephedrine, labetalol, and nadolol and complex molecules such as atropine, methorphan, and verapamil (9-11). Anionic molecules such as the a-methylarylacetic add antiinflammatory agents ibuprofen, fenoprofen, and naproxen can also be resolved on the AGP CSP (9-11). All these compounds can be resolved without precolumn derivatization. [Pg.167]

The FDA has announced its intention to require alcohol warnings on all over-the-counter pain medications that contain acetylsalicylic acid, salicylates, paracetamol, ibuprofen, ketoprofen, or naproxen. The proposed warnings are aimed at alerting consumers to the specific risks incurred from heavy alcohol consumption and its interaction with analgesics. For products... [Pg.24]

Ruthenium(binap) complexes effectively catalyze asymmetric hydrogenation of a-amidocinnamic acids [172], allylic alcohols [173] and acrylic acids with almost quantitative enantiomeric excess [174]. For example, one of the largest-selling anti-inflammatory agents, Naproxen should be supplied as the enantiomerically pure 5-isomer, because the R-isomer is expected to be toxic to the liver. Asymmetric hydrogenation of the precursor by RuCL[(5)- binap] produces 5-Naproxen with 96-98 % ee (eq (47)) [175-176]. [Pg.189]

The enzyme was not deactivated by SCCO2 and was active even in the absence of water, but the optimum rate was found at a water concentration of 0.5-1 mL/L. At 25% conversion, the e.e. of the ester was 92%, in favor of the S ester (e.e. = enantiomeric excess). The same reaction was found by Overmeyer et al. (76) to be catalyzed by a lipase from Candida antarctica B, which esterified the R enantiomer, but the enantioselectivity was poor. Wu and Liang (77) found that the enantioselectivity of esterification of racemic naproxen [Eq. (2)] was a strong function of the concentration of alcohol, with the greatest selectivity being obtained at lower alcohol concentrations. [Pg.467]


See other pages where Naproxen Alcohol is mentioned: [Pg.75]    [Pg.76]    [Pg.56]    [Pg.220]    [Pg.171]    [Pg.228]    [Pg.1350]    [Pg.325]    [Pg.18]    [Pg.456]    [Pg.618]    [Pg.1520]    [Pg.1529]    [Pg.746]    [Pg.34]    [Pg.311]    [Pg.186]    [Pg.4131]    [Pg.90]    [Pg.94]    [Pg.188]    [Pg.2688]    [Pg.17]    [Pg.112]    [Pg.789]    [Pg.189]    [Pg.144]   
See also in sourсe #XX -- [ Pg.71 ]




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