Nanotechnology approaches

Saf e-Siebert, R., etal., Nanotechnology approaches to solving the problems of poorly water-soluble drugs,Drug Discov. VNforld Summer, 6, 71, 2005. 

In the following the development is presented of a general approach for the synthesis of symmetrically and differently l,4" -substituted p-quaterphenylenes by application of a reliable Suzuki cross-coupling strategy. Experimental details are not given here but can be found elsewhere [51-53]. Note that organic synthesis is a key step for the bottom-up nanotechnology approach. 

Electrokinetic phenomena is no longer merely a laboratory curiosity. It is a key component of present-day microscale analysis. Looking toward the future, it may well be that some of the current techniques will be supplemented by nanotechnology approaches, but fluid control and ion movement will likely still involve electric fields. This book will afford the reader an appreciation of the power of electrokinetic phenomena. I congratulate the editors on the breadth of coverage and the timeliness of the topic. 

The development of surfaces with making use of probes of scanning tunneling microscopes (STM) and atomic-force microscopes (AFM) seems to be the first nanotechnology approach in exploration of unique properties of nanostructures in nanoeleetronics and nanosystems [1],... 

Mechanical stretching of ceU membranes can be achieved by nanotechnological approaches and it can direct and control the intracellular signaling and differentiation of stem cells 136]. Modifications made to the spatial distribution or cytoskeletal re-organization provide physical impetus, whereby the mechanical deformation becomes translated into biochemical responses [37]. When the cells encounter... 

Nanotechnological approaches will lead to defined structures on the molecular level by implementing active side groups or isolated particles as well as by crosslinking via side chains. Specially designed chemicals such as ionic liquids (ILs) allow the immobilisation and as a consequence the defined disfribution of active particles such as catalysts. These kinds of chemicals can also be used to functionalise inorganic structures such as zeolites or molecular sieves. 

Kim, E.S., Ahn, E.H., Dvir, T., Kim, D.H. Emerging nanotechnology approaches in tissue engineering and regenerative medicine. International Journal of Nanomedicine... 

The simultaneous presence of covalent bond formation and surface saturation has been shown to provide good homogeneity of metal concentration throughout the particles, excellent reproducibility of the process as evaluated on both macroscopic and atomic scale, and feasible scale-up. The nanotechnological approach, which is dominating materials science today, is demonstrated in the ALE method, which can produce atomically controlled structures even on high surface areas. The build-up of structures in nano-scale, not only with one component but with multicomponents, is already a reality. 

Silva, G.A., 2007. Nanotechnology approaches for drug and small molecule delivery across the blood brain barrier. Surgical Neurology 2, 113-116. 

Talking about dimensions, and now that total immersion on nanotechnological approaches is occurring, could be interesting comment that a basic antibody molecule approximates 10 nm in length. Therefore, these molecules are very appropriate tools for constructing bottom-up nanotechnological approaches. 

Nanotechnology Approaches to Crossing the Blood-Brain Barrier 332 and Drug Delivery to the CNS... 

Parts of this paper were adapted from a more detailed review on nanotechnology approaches for crossing the BBB written by the author [21]. This work was supported by funds from NIH grant NINDS NS054736. 

Silva GA Nanotechnology approaches for drug and small molecule delivery... 

Mills, K., Fleddermann, C. (2005). Getting the best from nanotechnology Approaching social and ethical implications openly and proactively. IEEE Technology and Society Magazine, 24(4), 18-26. 

Santo, V.E., Gomes, M.E., Mano, J.F., Reis, R.L., 2012. From nano- to macro-scale nanotechnology approaches for spatially controlled dehvery of bioactive factors for bone and cartilage engineering. Nanomedicine (Lxjnd) 7, 1045-1066. 

Materials and Surfaces A Nanotechnology Approach, John Wiley Sons, Ltd. 

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