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Drug conjugates

Numerous experimental therapeutics have shown potency in vitro however, when they are tested in vivo, they often lack significant efficacy. This is often attributed to unfavorable pharmacokinetic properties and systemic toxicity, which limit the maximum tolerated dose. These limitations can be overcome by use of drug carriers. Two general types of carrier systems have been designed drug conjugation to macromolecular carriers, such as polymers and proteins and drug encapsulation in nanocarriers, such as liposomes, polymersomes and micelles. [Pg.84]

UETAL. Poly(a-amino acid) Drug Conjugates... [Pg.113]

A general configuration of an ideal macromolecula-drug conjugate is shown in Fig. 15 [206], The drug can... [Pg.566]

Fig. 15 A schematic representation of an ideal macromolecule-drug conjugate. (From Ref. 206.)... Fig. 15 A schematic representation of an ideal macromolecule-drug conjugate. (From Ref. 206.)...
Polymers as Drugs, Conjugates and Gene Delivery Systems... [Pg.3]


See other pages where Drug conjugates is mentioned: [Pg.889]    [Pg.231]    [Pg.85]    [Pg.86]    [Pg.9]    [Pg.9]    [Pg.12]    [Pg.12]    [Pg.14]    [Pg.88]    [Pg.103]    [Pg.103]    [Pg.104]    [Pg.105]    [Pg.107]    [Pg.109]    [Pg.109]    [Pg.110]    [Pg.111]    [Pg.115]    [Pg.117]    [Pg.117]    [Pg.67]    [Pg.553]    [Pg.566]    [Pg.566]    [Pg.566]    [Pg.567]    [Pg.567]    [Pg.568]    [Pg.568]    [Pg.569]    [Pg.573]    [Pg.226]    [Pg.229]    [Pg.562]    [Pg.832]    [Pg.233]    [Pg.122]   
See also in sourсe #XX -- [ Pg.824 ]

See also in sourсe #XX -- [ Pg.276 ]




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Antibody drug conjugates

Antibody-Drug Conjugates in Oncology

Antibody-drug conjugates requirements

Antibody-drug/toxin conjugates

Bile acid-drug conjugates

Biomedical applications polymer-drug conjugates

Cancer antibody drug conjugates

Cancer therapy, polymer—drug conjugates

Chemotherapy with drug conjugates

Conjugate addition, to activate drugs

Conjugates for drugs

Conjugation Of drugs

Conjugation, drug metabolism

Conjugative Metabolism of Drugs

Cyclodextrin drug conjugates

Dendrimer—drug conjugates

Doxorubicin, drug-polymer conjugate

Drug biotransformation conjugates

Drug carriers doxorubicin-conjugated

Drug conjugation

Drug conjugation

Drug delivery folic acid conjugated with

Drug metabolism amino acid conjugation

Drug metabolism conjugated metabolites

Drug-antigen conjugate

Drug-carrier conjugates

Drug-lipid conjugates

Drug-macromolecule conjugate

Drug-polymer conjugates, controlled-release

Drugs conjugation to toxins

Drugs siderophore drug conjugates

Excipient-Drug Conjugates

Folate-drug conjugates

Glutathione drug conjugates

Hepatic microsomal drug metabolizing acid conjugates

Immunogenicity of Free and Conjugated Drugs

Ligand-drug conjugates

Macromolecular drug conjugates

Molecule anticancer drugs conjugate

Monoclonal Antibody-Drug Conjugates

Non-Peptide Drug Conjugation

Pharmacokinetic drug - carrier conjugate

Poly drug conjugate

Poly(ethylene) Glycol Conjugates of Biopharmaceuticals in Drug Delivery

Polyethylene glycol drug conjugates

Polymer-Drug Conjugation Strategy and Possible Benefits

Polymer-drug conjugate

Polymer-drug conjugates Subject

Polymeric drug conjugates

Polymer—drug conjugates responsive

Polyphosphazene-drug conjugates

Protein-drug conjugates

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