Tumor drug targeting

MA M10 M10.014 Membrane-type matrix m etallo pe pt id ase-1 Potential drug target for tumor cell invasion... 

MA M12 M12.217 ADAM17 peptidase Potential drug target for control of formation of tumor necrosis factor alpha... 

Maeda H (2001) The enhanced permeability and retention (EPR) effect in tumor vasculature the key role of tumor-selective macromolecular drug targeting. Adv Enzyme Regul 41 189-207... 

Ras is strictly localized to the inner side of the plasma membrane. A lipid anchor covalently attached to the C-terminus of Ras penetrates into the lipid bilayer. This membrane anchorage is essential for the biological activity of Ras. Hence, the inhibition of anchor attachment has become an attractive pharmacological target [ 13]. See Waldmann H, Thutewohl M,Ras-Farnesyltransferase-inhibitors as promising anti-tumor drugs, this volume. 

Interestingly, since the expression levels of several of these demethylases are increased in primary tumors (Table 13.1) and it is speculated that the demethylases contribute to tumor formation and maintenance, they present strong candidate drug targets. 

Anwer, K., G. Kao, B. Proctor, A. Rolland, and S. Sullivan, Optimization of cationic lipid/DNA complexes for systemic gene transfer to tumor lesions. J Drug Target, 2000. 8(2) 125-35. 

---