Targeted drug delivery system

Table 14 Examples of Erythrocyte-Targeted Drug-Delivery Systems...

B. Modeling Prodrugs and a Targeted Drug Delivery System... 

All in all, uptake studies with targeted systems carrying a pH-dependent fluorescent label in conjunction with monensin treatment at the end of the incubation period offer the possibility to discriminate between different intracellular trafficking pathways. At 37°C, an increasing fluorescence emission upon addition of monensin points toward accumulation of the targeted drug delivery system within acidic compartments of the cell, such as lysosomes. 

In addition to the detection methods described hitherto, binding and uptake of targeted drug delivery systems can be determined by flow cytometric analysis. Similar to conventional fluorimetric techniques, flow cytometry... 

Elucidation of intracellular trafficking and localization by means of CLSM is widely spread in the field of targeted drug delivery systems. Thus, CLSM analysis was performed to determine uptake and intracellular distribution of potential targeters [25, 43], drug conjugates [44, 45], as well as nanoparticles... 

Kaneda, Y. (2000) Virosomes evolution of the liposome as a targeted drug delivery system. Adv. Drug Deliv. Rev., 43, 197-205. 

Chourasia MK, Jain SK. Pharmaceutical approaches to colon targeted drug delivery systems. J Pharm Pharm Sci. 2003 6 33-66. 

Future Outlook for Physically Targeted Drug Delivery Systems 369... 

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