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Nanoparticles, oral drug delivery systems

Sarparanta MP, Bimbo LM, Makila EM, Salonen JJ, Laaksonen PH, Helariutta AMK, Linder MB, Hirvonen JT, Laaksonen TJ, Santos HA, Airaksinen AJ (2012) The mucoadhesive and gastroretentive properties of hydrophobin-coated porous silicon nanoparticle oral drug delivery systems. Biomaterials 33(ll) 3353-3362... [Pg.12]

Deutel, B., M. Greindl, et al. (2008). Novel insulin thiomer nanoparticles in vivo evaluation of an oral drug delivery system. Biomacromolecules 9(1) 278-85. [Pg.165]

The preparation of cationic lipid nanoparticles containing a lipophilic drug and its encapsulation into an anionic polymer network by ionic interaction for use as an oral drug delivery system are reported. The lipid nanoparticles serve as the core of a capsule, which is produced from a semi-interpenetrating polymer network of sodium alginate and hydroxypropylmethylcellulose. Satisfactory drug release is achieved through control of the composition of the capsule material and environmental pH. 14 refs. [Pg.61]

Bummer PM. Physical chemical considerations of lipid-based oral drug delivery—Solid lipid nanoparticles. Critical Reviews in Therapeutic Drug Carrier Systems. 2004 21(1) 10-20. [Pg.1402]

Parenteral administration (injection), which is the immediate option for orally undeliverable drugs, has advanced greatly in recent years for systemic and local drug delivery. " The novel drug delivery system has metamorphosed from simple polymer and antibody conjugates to sterically stabilized colloidal systems. Liposomes and nanoparticles can improve pharmacokinetic-pharmacody-... [Pg.487]

Herein, various barriers to oral delivery of macromolecular drugs will be discussed in brief, after which carrier-mediated delivery systems on the basis of chemical modification of the drugs and particulate drug carriers (e.g., nanoparticles, microcapsules, and liposomes) will be introduced as representative of promising approaches currently being investigated. [Pg.307]

Pan Y, Li YJ, Zhao HY, Zheng JM, Xu H, Wei G, Hao JS, Cui FD (2002) Bioadhesive polysaccharide in protein delivery system chitosan nanoparticles improve the intestinal absorption of insulin in vivo. Int J Pharm 249(1-2) 139-147 Park K, Robinson JR (1984) Bioadhesive polymers as platforms for oral-controlled drug delivery method to study bioadhesion. Int J Pharm 19 107-127 Patel H, Ryman BE (1981) Systemic and oral administration of liposomes. In Knight CG(ed) Liposomes From Physical Structure To Therapeutic Applications, Elsevier, Amsterdam, pp 409-441... [Pg.191]

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See also in sourсe #XX -- [ Pg.461 ]



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