Lipid-based oral drug delivery

Bummer, PM. (2004) Physical chemical considerations of lipid-based oral drug delivery-solid lipid nanoparticlesCrit. Rev. Therap. Drug Carrier Syst., 21 1-19. 

Porter, C. J. H. and W. N. Charman, 2001 vitro assessment of oral lipid based formulatioftdvanced Drug Delivery ReviewSO S127-S147. 

Vasanthavada, M. and A. T. M. Serajuddin. Lipid-based self-emulsifying solid dispersidripid-n Based Formulations for Oral Drug Delivery Enhancing the Bioavailability of Poorly Vteter-Soluble Drugs, ed. D. J. Flauss, 149-183. New York Informa Healthcare. 

In the following, lipid-based systems for oral drug delivery of peptides and proteins have been classified into liposomes and emulsions, although the distinction between these classifications is somewhat vague. 

Porter CJ, Trevaskis NL and Charman WN (2007) Lipids and Lipid-Based Formulations Optimizing the Oral Delivery of Lipophilic Drugs. Nat Rev Drug Discov 6 pp 231-248. 

Wasan, K. M. 2001. Formulation and physiological and biopharmaceutical issues in the development of oral lipid-based drug delivery systerrBrug Development and Industrial Pharmacy. 27 267-276. 

Microemulsions, and Lipid-Based Drug Delivery Systems for Drug Solubilization and Delivery—Part II Oral Applications... 

Toxicological Considerations for Oral Lipid-Based Drug Delivery Systems. 248... 

Cannon, J. (2005) Oral solid dosage forms of lipid-based drug delivery systemSharm. Rey8 108-113. 

Humberstone, A.J. and Charman, WN. (1997) Lipid-based vehicles for the oral delivery of poorly water soluble drugsAdv. Drug Del. Rev., 25 103-128. 

In this chapter we will provide a brief overview of the early approaches to bioavailability enhancement by use of simple lipid-based delivery systems (lipid solutions, emulsions etc), and then describe recent progress in the application of self-emulsifying- and microemulsion-based formulations. The effects of lipids on the oral bioavailability of co-administered poorly water-soluble drugs may also be classified from a mechanistic (and to a degree, historical) perspective as physicochemically mediated effects (solubility, dissolution, surface area) and biochemically mediated effects (metabolism, transport related events), and these will be approached separately. It is readily apparent, however, that in many cases physicochemically and biochemically mediated mechanisms will operate side by side. In some instances, bioavailability may also be enhanced by the stimulation of intestinal lymphatic transport, and these studies will be addressed in a separate section. 

Hauss, D. J. (2002), Oral lipid-based drug delivery—a case of implementation failing to keep up with innovation Am. Pharm. Rev., 5, 22-36. 

Porter CJH, Trevaskis, NL, Charman, WN. Lipids and lipid-based formulations Optimizing the oral delivery of lipophilic drugs. Nat. 

Dahan, A. and Hoffman, A. (2008) Rationalizing the selection of oral lipid based drug delivery systems by an in vitro dynamic lipolysis model for improved oral bioavailability of poorly water soluble drugs. Journal of Controlled Release, 129 (1), 1-10. 

Porter, C.J.H. and Charman, W.N. (2001) In vitro assessment of oral lipid based formulations. Advanced Drug Delivery Reviews, 50 (Suppl. 1), S127. 

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