N methyl ester

CARBOXYPHENETHYL)SUCCINAMIC ACID N-METHYL ESTER, steteoisomet see ARN825 m-AMINOCHLOROBENZENE see CEH675 1-AMINO-2-CHLOROBENZENE see CEH670 1-AMINO-3-CHLOROBENZENE see CEH675 1-AMINO-4-CHLOROBENZENE see CEH680 1-AMINO-4-CHLOROBENZENE HYDROCHLORIDE see CJR200... 

Amino-N-(a-carboxyphenethyl)succinamic acid N-methyl ester 3-amino-N-(a-methoxycarbonylphenethyl)succinamic acid APM aspartyl phenylamine methyl ester Canderel E951 Equal, methyl N-a-L-aspartyl-L-phenylalaninate NutraSweet Pal Sweep, Pal Sweet Diet-, Sanecta SC-18862 Tri-Sweet. 

Aspartame. [Nutrasweet]. (3-amino-n-(a-carboxyphenethyl)succinamic acid n-methyl ester, stereoisomer aspartylphenylalanine methyl ester n-l-a-aspartyl-l-phenylalanine 1-methyl ester canderel dipeptide sweetener Equal (TM) methyl aspartylphenylalanate 1-methyl n-l-a-as-partyl-l-phenylalanine Nutrasweet (TM) sweet dipeptide). C14H18N205. 

Amino-N-(a-methoxycarbonylphenethyl) succinamic acid 3-Amino-N-(a-carboxyphenethyl)succinamic acid N-methyl ester APM Asp-phe-ome Aspartam Aspartame Aspartame, L,L-a- Aspartamo Aspartamum Aspartylphenylalanine methyl ester L-Aspartyl-L-phenylalanine methyl ester Canderel CCRiS 5456 DIpeptide sweetener EINECS 245-261-3 Equal HSDB 3915 Methyl aspartylphenylalanate Methyl L-aspartyl-L-phenylalanine Methyl L-a-aspartyl-L-phenylalanate Methyl N-L-a-aspartyl-L-phenylalaninate 1-Methyl N-L-a-aspartyl-L-phenylalanate Nutrasweet L-Phenylalanine, L-a-aspartyl-, 2-methyl ester L-Phenylalanine, N-L-a-aspartyl-, 1-methyl ester SC 18862 Succinamic acid, 3-amino-N-(a-carboxyphenethyl)-, N-methyl ester, Sweet dipeptide Tri-sweet, A sweetening agent Crystals mp = 246-247° [a]8 = -2,3° (IN HCI). Searte 6.D. Co. 

Methyl ether —O—CH3 Nitro —NO2 Cyano —C=N Methyl ester —COjCH,... 

Amino-N-(a-carboxyphenethyl) succinamic acid N-methyl ester. See Aspartame... 

Synonyms 3-Amino-N-(a-carboxyphenethyl) succinamic acid N-methyl ester APM Aspartylphenylalanine methyl ester N-l-a-Aspartyl-l-phenylalanine l-methyl ester Methyl aspartylphenylalanate 1 -Methyl N-L-a-aspartyl-L-phenylalanine Classification Dipeptide Definition Consists of L-aspartic acid and the methyl ester of L-phenylalanine artificial sweetener... 

The formation of 4-cyano p3rrazole derivatives 3 can be rationalized as the acid protonated nitrogen of dimethylamino group and was replaced by hydrazine and then NH2 of the hydrazine condenses with carbonyl carbon to form pyrazole ring. When the condensation of 3-dimethylarnino-2-bezoyl-propenenitrile la and N-methyl ester of hydrazine was carried out, the ester group has been hydrolyzed and decarboxylated to give IH-pyrazole derivative 3f. 

Methyl p-toluenesulphonate. This, and other alkyl esters, may be prepared in a somewhat similar manner to the n-butyl ester with good results. Use 500 g. (632 ml.) of methyl alcohol contained in a 1 litre three-necked or bolt-head flask. Add 500 g. of powdered pure p-toluene-sulphonyl chloride with mechanical stirring. Add from a separatory funnel 420 g. of 25 per cent, sodium hydroxide solution drop by drop maintain the temperature of the mixture at 23-27°. When all the alkali has been introduced, test the mixture with litmus if it is not alkaline, add more alkali until the mixture is neutral. Allow to stand for several hours the lower layer is the eater and the upper one consists of alcohol. Separate the ester, wash it with water, then with 4 per cent, sodium carbonate solution and finally with water. Dry over a little anhydrous magnesium sulphate, and distil under reduced pressure. Collect the methyl p-toluenesulphonate at 161°/10 mm. this solidifies on cooling and melts at 28°. The yield is 440 g. 

Chiral 2-oxazolidones are useful recyclable auxiliaries for carboxylic acids in highly enantioselective aldol type reactions via the boron enolates derived from N-propionyl-2-oxazolidones (D.A. Evans, 1981). Two reagents exhibiting opposite enantioselectivity ate prepared from (S)-valinol and from (lS,2R)-norephedrine by cyclization with COClj or diethyl carbonate and subsequent lithiation and acylation with propionyl chloride at — 78°C. En-olization with dibutylboryl triflate forms the (Z)-enolates (>99% Z) which react with aldehydes at low temperature. The pure (2S,3R) and (2R,3S) acids or methyl esters are isolated in a 70% yield after mild solvolysis. 

This procedure is representative of a new general method for the preparation of noncyclic acyloins by thiazol ium-catalyzed dimerization of aldehydes in the presence of weak bases (Table I). The advantages of this method over the classical reductive coupling of esters or the modern variation in which the intermediate enediolate is trapped by silylation, are the simplicity of the procedure, the inexpensive materials used, and the purity of the products obtained. For volatile aldehydes such as acetaldehyde and propionaldehyde the reaction Is conducted without solvent in a small, heated autoclave. With the exception of furoin the preparation of benzoins from aromatic aldehydes is best carried out with a different thiazolium catalyst bearing an N-methyl or N-ethyl substituent, instead of the N-benzyl group. Benzoins have usually been prepared by cyanide-catalyzed condensation of aromatic and heterocyclic aldehydes.Unsymnetrical acyloins may be obtained by thiazol1um-catalyzed cross-condensation of two different aldehydes. -1 The thiazolium ion-catalyzed cyclization of 1,5-dialdehydes to cyclic acyloins has been reported. 

Solid esters are easily crystallisable materials. It is important to note that esters of alcohols must be recrystallised either from non-hydroxylic solvents (e.g. toluene) or from the alcohol from which the ester is derived. Thus methyl esters should be crystallised from methanol or methanol/toluene, but not from ethanol, n-butanol or other alcohols, in order to avoid alcohol exchange and contamination of the ester with a second ester. Useful solvents for crystallisation are the corresponding alcohols or aqueous alcohols, toluene, toluene/petroleum ether, and chloroform (ethanol-free)/toluene. Esters of carboxylic acid derived from phenols... 

Alternatively, the acid (5g) is refluxed for 2h with 15mL of MeOH and 2mL of 98% H2SO4 (cool when mixing this soln). Pour into 10 volumes of H2O and extract with the minimum volume of CHCI3 to give clear separation of phases. The extract is washed with H2O and dried (CaCl2) and distd. The methyl ester is collected at 77-79°/ mm, m 38-39°. The ester is hydrolysed with the calculated amount of N KOH and refluxed until clear. Acidification with HCl provides the pure acid with 90% recovery. [Org Synth 4 1 1964.] The amide crysts from cyclohexane, m 189°. [Chem Ber 62 1629 1959.]... 

Capric acid (decanoic acid) [334-48-5] M 172.3, m 31.5 , b 148 /llmm, d 0.886, n s 1.424, pKesi -4.9. Purified by conversion to its methyl ester, b 114.0 /15mm (using excess MeOH, in the presence of H2SO4). After removal of the H2SO4 and excess MeOH, the ester was distd under vacuum through a 3ft... 

Myristic acid (tetradecanoic acid) [544-63-8] M 228.4, m 58 , pK 6.3 (50% EtOH), pK si -4.9 (H2O). Purified via the methyl ester (h 153-154 /10mm, n 1.4350), as for capric acid. [Trachtman and Miller y/4m Chem Soc 84 4828 7962.] Also purified by zone melting. Crystd from pet ether and dried in a vacuum desiccator containing shredded wax. 

Other functional groups that are easily differentiated are cyanide (5c =110-120) from isocyanide (5c = 135- 150), thiocyanate (5c =110-120) from isothiocyanate (5c = 125 - 140), cyanate (5c = 105- 120) from isocyanate (5c = 120- 135) and aliphatic C atoms which are bonded to different heteroatoms or substituents (Table 2.2). Thus ether-methoxy generally appears between 5c = 55 and 62, ester-methoxy at 5c = 52 N-methyl generally lies between 5c = 30 and 45 and. S-methyl at about 5c = 25. However, methyl signals at 5c = 20 may also arise from methyl groups attached to C=X or C=C double bonds, e.g. as in acetyl, C//j-CO-. 

N-Methyl pyrrolidone, dibasic ethers, and organic esters, substituting for more hazardous paint removers (Paint Removers, 1991 Davis et al., 1994)... 

Aristinic acid, CijHigO N. This crystallises from hot acetic acid in greenish-yellow leaflets or needles, m.p, 275° (dec.). The potassium salt, CijHjaO NK. 2H2O, forms reddish needles and the methyl ester yellow needles, m.p. 250°. 

Aristolochic Acid. Rosenmund and Reichstein prepared their material from roots and rhizomes of A. Sipho. It has the formula Cj HjiO N, m.p. 275° (dec.), and forms a methyl ester, m.p. 280° (dec.), [a]n 0°, which is difficult to saponify and on. hydrogenation gives a bright yellow substance, m.p. 312°, which forms a diacetyl... 

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