Methoxy ethers

Methane, diphenyl methoxy [Ether, di phenylmethyl methyl], 55, 5 Metharte, iodo-, 55, 3 METHANE, iodo-, hazard note, 55, 134 Methane, (4 (l-methylethvl)phenyl)-phenyl-[Melliane, (4-isopropylphenyl)-phen-yl-], 55,11... 

The derived enthalpies of formation of the n-propyl and ec-butyl lithiated methoxy ethers are —260 and —275 kJmon, respectively, from equation 16, the enthalpies of protodelithiation, the enthalpy of formation of n-butyl lithium from Table 1 and of liquid n-butane, and the measured enthalpies of formation of methyl n-propyl ether (Iq, —266.0 ... 

The enthalpy of formation of methyl n-pentyl ether is unavailable from experiment, but a value of —316 kJmoP is obtained from the linear regression analysis of the known enthalpies of formation of methyl n-alkyl ethers vs. the number of carbon atoms in the ethers . The methylene increment of —25.3 kJmoP for this homologous ether series is nearly identical to the methylene increment for n-alkanes. Because the experimental protodelithiation enthalpies for the two primary lithio ethers are identical, the methylene increment in that homologous series as calculated here is necessarily identical to that of the homologous methoxy ethers. As calculated from the methylene increment or from equation 16, the enthalpy of formation of 5-lithiopentyl methyl ether is ca —309 kJmol. ... 

Neurokinins comprise a group of peptides involved in nerve transmission. Specific members of this class of mediators control such diverse functions as visceral regulation and CNS function. The nonpeptide neurokinin antagonist talnetant (32-6), for example, has been evaluated for its effect on irritable bowel syndrome and urinary incontinence as well as depression and schizophrenia [36]. The quinoline portion of this compound is prepared by base-catalyzed Pfitzinger condensation of isatin (32-1) with the methoxy acetophenone (32-2). The methoxy ether in the product (32-3) is next cleaved by means of hydrogen bromide (32-4). Amide formation with the chiral a-phenylpropylamine (32-5) affords the neurokinin antagonist talnetant (32-6) [37]. 

Alternatively the cyclization of the amine i to the methoxy ether derivative ii can be performed by the following reaction sequence. 

In jS-chloroketones the C—Cl and C=0 groups show significant interaction, if the two entities are in the correct orientation with respect to each other136. This interaction results in an appreciable cr component in the LUMO of the / -chloroketone, and makes the C—Cl bond potentially photolabile in the excited state12,136. Indeed, irradiation of 4-chloro-2-butanone in methanol has been reported to afford the corresponding 4-methoxy ether in addition to the alcohol resulting from carbonyl reduction. The apparent nucleophilic photosubstitution product, however, turns out to be produced in a dark reaction, catalysed by acid which is formed when methanol solutions are irradiated255. 

Disposition in the Body. Slowly but completely absorbed following oral administration. It appears to undergo significant first-pass metabolism bioavailability about 70%. After intravenous administration, about 57% of a dose is excreted in the urine and 30% in the faeces over a period of 21 days less than 10% of the dose is excreted as unchanged drug. The principal metabolite is the desmethyl derivative, which has been shown to be active in animals, but hydroxylation also occurs to form phenolic derivatives which may be further converted to aromatic methoxy ethers or excreted as glucuronide conjugates A -oxidation also occurs and maprotiline A -oxide has been reported to be active numerous minor metabolites have been identified in urine. 

Acharya, J., Gupta, A.K., Mazumder, A., Dubey, D.K. (2008a). In vitro reactivation of sarin inhibited electric eel acetylcholinesterase by bis-pyridinium oximes bearing methoxy ether linkages. Toxicol. In Vitro 22 525-30. 

SYNS BENZENE, METHOXY ETHER, METHYL PHENYL FEMA No. 2097 METHOXYBENZENE METHYL PHENYL ETHER PHENYL xMETHYL ETHER... 

The imexpected formation of the methoxy ether (69b) in the reaction of lanosterol 5-methyl dithiocarbonate (69a) with BuaSnH has been reported. Studies using BuaSnD indicated that a hydrogen within the methoxy group originated from the organostannane reagent. A possible mechanism (Scheme 28) was postulated to explain these observations. ... 

At this juncture, a series of investigations139) concerning the relative reactivities of the phenolic functions were undertaken in order to form the basis for the regio-selective generation of the 4-hydroxy-6-methoxy system. The information obtained provided the following facts (a) selective methylation (diazomethane) of (9J), gave the 4-methoxy ether (96) and, (b) selective deprotection of the dibenzyl ether (97)... 

METHOXY ETHER of PROPYLENE GLYCOL (107-98-2) see polypropylene glycol methyl ether. 

METHOXY ETHER of PROPYLENE GLYCOL (107-98-2) Forms explosive mixture with air (flash point 90°F/32°C). Violent reaction with strong oxidizers, alkalis. Incompatible with aliphatic amines, boranes, sulfuric acid, nitric acid, perchloric acid, caustic materials, isocyanates. 

Agrisynth MVE EINECS 203-475-4 Ethene, methoxy- Ether, ethenyl methyl Ether, methyl vinyl HSDB 1033 Methoxyethene 1-Methoxyethylehe Methyl vinyl ether UN1087 Vinyl methyl ether. Gas mp = -122 bp = 5.5" d = 0.7725 slightly soluble in H2O, very soluble in EtOH, Et20, Me2CO, CeHe. 

The methoxy ethers of the amino alcohols obtained from the addition of methyl-, ethyl-, or phenylmagnesium halide to 7V-benzylproline methyl esters can be converted to the corresponding, /V-amino derivatives by exactly the same procedures as described for SAMP10. The products [e.g., SADP, (S)-27, the a,a-dimethyl product] form azaenolates with carbonyl compounds which are used in enantioselective a-oxidations (Section D.4.I.). 

Eli LUly has published the de-methylation of an aromatic methoxy group in ionic liquids [9]. Usually the cleavage of aromatic methoxy ethers requires very harsh conditions and inconvenient reagents, such as BBrs [13] or HBr in boiling acetic acid [14]. 4-Hydroxyphen)4butyric add has been produced by Eli Lilly on a 190 L pilot scale with yields of >94% by reacting 4-methoxyphenylbutyric acid for 2 h at 210 °C in the ionic liquid pyridinium hydrochloride ([PyH]Q) (Scheme 9-7). 

Cleavage of Haloethyl Derived Protecting Groups. Samarium diiode is a mild and effective reagent for the deprotection of 2-bromoethyl and 2-iodoethyl esters and (2,2,2-trichloroethoxy) methoxy ethers. ... 

Neurokinines comprise of a group of peptides involved in nerve transmission. The nonpeptidic neurokinin antagonist talnetant has been evaluated for its effect on irritable bowel syndrome (IBS) and urinary incontinence as well as depression and schizophrenia. The quinoline portion of this compound has been prepared through a Pfitzinger condensation of isatin with methoxy acetophenone. Methoxy ether cleavage and amide... 

Methoxy ether of propylene glycol. See Methor isopropanol 2-(2-Methoxyethox] ethanol. See Methor iglycol 2-(2-(2-Methoxyethox] ethox] ethanol. See Triglycol monomethyl ether Methoxyethyl acetate 2-Methoxyethyl acetate Methoiqrethyl acetate. 

CAS 100-66-3 El NECS/ELINCS 202-876-1 UN 2222 (DOT) FEMA 2097 Synonyms Benzene, methoxy Ether, methyl phenyl Methoxybenzene Methylphenyl ether Phenol methyl ether Phenyl methylether Classification Ether Empirical C7H8O Formula CHaOCeHs... 

Methoxyethene, polymer with 2-butenedioic acid, monobutyl ester. See PVM/MA copolymer, butyl ester Methoxy ether of propylene glycol. See Methoxyisopropanol 2-(2-Methoxyethoxy) ethanol. See Methoxydiglycol... 

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