Succinamic acid

Succinic acid reacts with urea in aqeous solution to give a 2 1 compound having mp 141°C (116,117), which has low solubiUty in water. A method for the recovery of succinic acid from the wastes from adipic acid manufacture is based on this reaction (118,119). The monoamide succinamic acid [638-32-4] NH2COCH2CH2COOH, is obtained from ammonia and the anhydride or by partial hydrolysis of succinknide. The diamide succinamide [110-14-3], (CH2C0NH2)2, nip 268—270°C, is obtained from succinyl chloride and ammonia or by partial hydrolysis of succinonitrile. Heating succinknide with a primary amine gives A/-alkylsucckiknides (eq. 9). 

V-ethyl-V-(/7-methoxy-a-methylphenethyl)succinamic acid ethyl ester... 

HPLC analysis for succinic acid, succinamic acid, succinamide, succinimide, N-methylsuccinimide, butyric acid, and propionic acid was performed with a Waters Model 515 HPLC pump equipped with a Waters Model 2410 Refractive Index Detector. Separations were performed with an Aminex HPX-87H 300mm column (Bio-Rad Laboratories, Hercules, CA) operated at 35°C, and using 0.005 M H2S04 elluent. 

Monoalkylphosphates, 19 51 Monoalkylsulfosuccinates, 23 526 Monoalkyltin derivatives, as PVC stabilizers, 24 825 Monoallyl derivatives, 2 242-247 health and safety factors, 2 247-248 Monoaluminum phosphate, 18 839 Monoamide succinamic acid, 23 422... 

Though EM ratios are given for both reactions, the data are not independent. The EM s for the amide hydrolysis are based on a value (EM = 5.1 x 104 M) for the succinamic acid reaction which is assumed to be identical with that for the hydrolysis of monophenyl succinate monoanion. However, both sets of data show similar behaviour. The EM s for the rate processes, initially smaller by less then an order of magnitude than those for equilibrium anhydride formation, increase much less rapidly with increasing methyl substitution, so that the EM ratios decrease with increasing EM. 

EM for cyclization of succinamic acid assumed equal to that for cyclization of succinic esters (Table A.2 see text). Direct rate comparisons give EM s for substituted succinamic acids at 25°. No corrections for pX,... 

Kluger and Lam, 1978. Comparison with the rate constant calculated for succinamic acid at 50° gives EM = 5 x 101. Correction for the better leaving group uses the ratio of rates for maleamic and maleanilic acids measured by Aldersley et al. (1974b) at 39°... 

The corresponding imides (1.40), called fulgimides, are most readily synthesised by conversion of the fulgide into the succinamic acids by reaction with amines, followed by dehydration. Functionalisation of the anhydride can also be achieved by reaction of the fulgides with malononitrile in the presence of diethylamine and subsequent recyclisation with acetyl chloride to give (1.41) from the corresponding E-fulgide and (1.42) from the Z-isomer. 

Although Boc-peptide-OH can be synthesized in solution following the procedure as described above, the same fully protected segment can be synthesized by the solid-phase method using the Boc strategy on an AT-[9-(hydroxymethyl)-2-fluorenyl]succinamic acid... 

Figure 2. Notation for organic reactions used by Kekule in his 1858 paper for the hydrolysis of succinimide to succinamic acid.

Preparation of butyl-(—)-ecgonine 14C-l,4-succinamic acid methyl phosphate... 

CARBOXYPHENETHYL)SUCCINAMIC ACID N-iMETHYL ESTER, stereoisomer ASPARTYLPHENYLALANINE METHYL ESTER N-l-a-ASPARTYL-1-PHENYLALANINE 1-METHYL ESTER (9CI) CANDEREL DIPEPTIDE SWEETENER EQUAL METHYT-ASPARTYLPHENYLALANATE 1-METHYL N-l-a-ASPARTYL-l-PHENYLALANINE NUTRASWEET SWEET DIPEPTIDE... 

SYNS ALAR AL. R-85 AMINOZIDE B 995 BERKSTEINSAEURE-2,2-DIMETHYLHYDRAZID (GERMAN) B-NINE BUTANEDIOIC ACID i 10N0(2,2-DIMETHYLHYDRAZIDE) DAMINOZIDE (USDA) DIMAS N-DIMETHYL AMINO-P-CARBAMYL PROPIONIC ACID N-(DIMETHYLAMINO)SUCCINAMIC ACID N-DIMETHYLAMINO-SUCCINAMIDSAEURE (GERMAN) DMASA DMSA KYLAR NCI-C03827 SADH SUCCINIC ACID-2,2-DIMETHYLHYDR. ZIDE SUCCINIC-1,1-DIMETHYL HYDRAZIDE... 

CARBOXYPHENETHYL)SUCCINAMIC ACID N-METHYL ESTER, steteoisomet see ARN825 m-AMINOCHLOROBENZENE see CEH675 1-AMINO-2-CHLOROBENZENE see CEH670 1-AMINO-3-CHLOROBENZENE see CEH675 1-AMINO-4-CHLOROBENZENE see CEH680 1-AMINO-4-CHLOROBENZENE HYDROCHLORIDE see CJR200... 

DIMETHYLANENOSUCCINAMIC ACID see DQD400 N-piMETHYLAMINO)SUCCINAMIC ACID see... 

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