Glutamate N-methyl-D-aspartate

N-methyl-D-aspartate glutamate antagonists Inhibit glutamate excitotoxicity 1 drug approved... 

Eastwood SL, Kerwin RW, Harrison PJ. 1997b. Immunoautor-adiographic evidence for a loss of alpha-amino-3-hydroxy-5-methyi-4-isoxazole propionate-preferring non-N-methyl-D-aspartate glutamate receptors within the medial temporal lobe in schizophrenia. Biol Psychiatry 41 636-643. 

Blackstone CD, Moss SJ, Martin LJ et al (1992) Biochemical characterization and localization of a non-N-methyl-D-aspartate glutamate receptor in rat brain. J Neurochem 58 1118-1126... 

Sato K, Kiyama H, Tohyama M (1993) The differential expression patterns of messenger RNAs encoding non-N-methyl-D-aspartate glutamate receptor subunits (GluRl- ) in the rat brain. Neuroscience, 53, 515-539. 

Grb-2 facilitates the transduction of an extracellular stimulus to an intracellular signaling pathway, (b) The adaptor protein PSD-95 associates through one of its three PDZ domains with the N-methyl-D-aspartic acid (NMDA) receptor. Another PDZ domain associates with a PDZ domain from neuronal nitric oxide synthase (nNOS). Through its interaction with PSD-95, nNOS is localized to the NMDA receptor. Stimulation by glutamate induces an influx of calcium, which activates nNOS, resulting in the production of nitric oxide. 

Status epilepticus occurs because the brain fails to stop an isolated seizure. The exact reason for this failure is unknown and probably involves many mechanisms. A seizure is likely to occur due to a mismatch of excitatory and inhibitory neurotransmitters in the brain. The primary excitatory neurotransmitter in the brain is glutamate. Glutamate stimulates postsynaptic N-methyl-D-aspartate (NMDA) receptors in the brain, causing an influx of calcium into the cells and depolarization of the neuron. Sustained depolarization may maintain SE and eventually cause neuronal injury and death.7 The primary... 

Jacocks, H.M. and Cox, B.K., Serotonin-stimulated [3H]dopamine via reversal of the dopamine transporter in rat striatum and nucleus accumbens a comparison with release elicited by potassium, N-methyl-D-aspartic acid, glutamic acid and D-amphetamine, J. Pharmacol. Exp. Ther., 262, 356, 1992. 

Fedele, E., Varnier, G., Ansaldo, M.A., Raiteri, M. Nicotine administration stimulates the in vivo N-methyl-D-aspartate receptor/nitric oxide/cyclic GMP pathway in rat hippocampus through glutamate release. Br. J. Pharmacol. 125 1042, 1998. 

N-methyl-D-aspartate (NMDA) An amino acid agonist at the glutamate NMDA receptor. 

Seizure maintenance is largely caused by glutamate acting on postsynap-tic N-methyl-D-aspartate and a-amino-3-hydroxy-5-methyl-isoxazole-4-propionate/akinate receptors. Sustained depolarization can result in neuronal death. 

Cambonie G, Laplanche L, Kamenka JM, Barbanel G. 2000. N-Methyl-D-aspartate but not glutamate induces the release of hydroxyl radicals in the neonatal rat modulation by group I metabotropic glutamate receptors. J Neurosci Res... 

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