Acetamide, N- 2- ethyl

Fig. 7.19 Illustration of the additivity of conformational geometry functions for the -ro-tation in (CH3CO)(H)N-C(CH3)(H)(CONHCH3) (ALA). During the torsional motion about the N-C(a) bond of ALA, the interactions within the system are the same as those encountered during the N-C torsion in N-ethyl acetamide (NEA), plus those encountered during the N-C(a) torsion in N-acetyl N -methyl glycine amide offset by 120° as shown (GLY), minus those encountered during the N-C torsion in N-methyl acetamide (NMA).

Zaleplon was determined in the presence of its alkaline degradation product namely N-[4-(3-cyano-pyrazolo[l,5-fl]pyridin-7-yl)-phenyl]-N-ethyl-acetamide by measuring its D2 (second derivative) and aDD (first... 

Nikishin, G. I., and R. I. Musiafaev Free Radical Addition of N-Ethyl-acetamide to Unsaturated Systems. Dokl. Akad. Nauk SSSR 158, 1127 (1964) and references cited therein. 

N-ethylacetamide is formed by the reaction of ethyl-amine and acetylamide. When 9 grams of ethylamine is reacted, how many grams of N-ethyl acetamide can be formed ... 

Using acetic acid as your only source of carbon atoms, show how you could make N-ethyl acetamide. 

Chemical Name 2-(4-butoxyphenoxy)-N-(2,5-diethoxyphenyl)-N-[2-(diethylamino)ethyl] -acetamide... 

CN [/ -(/ , / )]-2,2-dichloro-N-[2-hydroxy-]-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide... 

The nonionic monomer can be acrylamide, N,N-dimethylacrylamide, N-vinyl-2-pyrrolidone, N-vinyl acetamide, or dimethylamino ethyl methacrylate. Ionic monomers are AMPS, sodium vinyl sulfonate, and vinylbenzene sulfonate. The terpolymer should have a molecular weight between 200,000 to 1,000,000 Dalton. 

N-vinyl acetamide, or dimethylamino ethyl methacrylate, 2-acrylamido-2-methylpropane sulfonic acid, sodium vinyl sulfonate, and vinylbenzene sulfonate... 

The objectives of this study were to (a) determine the mobilities of the herbicides, alachlor (2-chloro-2, 6 -diethyl-N-(me-thoxymethyl)acetanilide), butylate (S-ethyl diisobutylthiocarba-mate), and metolachlor (2-chloro-N-(2-ethyl-6-methyl phenyl)-N-(2-methoxy-l-methyl ethyl) acetamide in the laboratory using soil leaching columns and soil thin-layer vapor diffusion techniques,... 

Figure 10.4 Chemical structures of the clinically relevant melatonin analogs, compared with melatonin (5-methoxy-N-acetyltryptamine). Agomelatine N- 2-[7-methoxy-l-naphthalenyl]ethyl)acetamide. Ramelteon ...

Alternatively, dissolve 220 g 4-benzyloxy-3-indoleacetic acid (or equimolar amount other indoleacetic acid) in 2 L absolute methanol and reflux six hours in the presence of 20 g Dowex 50X8 sulfonic acid resin. Filter (decolor with carbon if desired) and concentrate below 35° until precipitation starts then cool to precipitate and filter to get 200 g of the methyl ester. Add 200 g of the ester to 600 ml 40% aqueous methylamine over twelve hours with vigorous stirring. Filter, wash precipitate with water and dry to get 187 g of the N-methyl-acetamide (reflux two hours in 500 ml benzene to remove unreacted ester). 24 g of the acetamide in 300 ml tetrahydrofuran is added dropwise to 10 g lithium aluminum hydride in 300 ml tetrahydrofuran reflux ten hours, cool to 15° and add dropwise with stirring 50 ml ethyl acetate. Reflux two hours and proceed as above to get 15 g (II) or analog. 

N-Ethyl-2.,3-dime tbylaniline, (CH3)3C6H3.NH.C2H5 mw 149.24, liq, bp 227—28°. It is prepd by hydrolysis of the corresponding acetamide with 40% H2S04... 

TRYPTAMINE, N-ACETYL-5-METHOXY INDOLE, 3-(2-ACETAMIDOETHYL)-5-METHOXY SEROTONIN, N-ACETYL-O-METHYL ACETAMIDE, N-[2-(5-METHOXYINDOL-3-YL)ETHYL] N-ACETYL-5-METHOXYTRYPTAMINE 3-(2-ACETAMIDOETHYL)-5-METHOXYINDOLE N-ACETYL-O-METHYLSEROTONIN N-[2-(5-METHOXYINDOL-3-YL)ETHYL]ACETAMIDE REGULIN... 

Moreover, the formation of enoxy-silanes via silylation of ketones127 by means of N-methyl-N-TMS-acetamide (1 72) in presence of sodium trimethylsilanolate (173) was reported in 1969 and since then, the use of silylating reagents in presence of a catalyst has found wide appreciation and growing utilization as shown in recent papers128-132 (Scheme 27). Diacetyl (181) can be converted by trifluoromethylsul-fonic acid-TMS-ester (182) into 2,3-bis(trimethylsiloxy)-l, 3-butadiene (7treatment with ethyl TMS acetate (7 5)/tetrakis(n-butyl)amine fluoride l-trimethylsiloxy-2-methyl-styrene (i<56)130. Cyclohexanone reacts with the combination dimethyl-TMS-amine (18 7)/p-toluenesulfonic acid to 1-trimethylsiloxy-l-cyclohexene (iSS)131. Similarly, acetylacetone plus phenyl-triethylsilyl-sulfide (189) afford 2-triethylsiloxy-2-pentene-4-one (790)132. ... 

---