N-acetyl-p-aminophenol

To the filtrate obtained, there are then added about 0.2 gram of sodium hydrosulfite or sodium sulfite and 15.0 grams of anhydrous sodium acetate in about 27 grams of acetic anhydride at 40°C. The reaction mixture formed is cooled to 8° to 10°C with stirring and held at this temperature for 60 minutes. A crystalline precipitate of about 27 grams of N-acetyl-p-aminophenol is obtained melting at 169°-171°C. This is equivalent to a yield of 85%. 

Example 1 65 grams of N-acetyl-p-aminophenol were slurried with 400 ml of water and cooled to 10°C. 125 ml of 20% sodium hydroxide were slowly added to the mixture with... 

Example 2 65 grams of sodium N-acetyl-p-aminophenol were slurried with 500 grams of dry benzene and 80 grams of acetyl salicoyl chloride added. The mixture was heated under reflux for four hours and filtered hot. The excess benzene was removed under vacuum and the crude acetyl salicyclic acid ester of N-acetyl-p-aminophenol crystallized from ethanol. 

Acetylium tetrailuoroborate, 4 144t N-Acetyl-p-aminophenol (acetaminophen), acetic anhydride used in production of, 1 158. See also Acetaminophen Acetyl perchlorate, 1 157 Acetylsalicylic acid (aspirin), 22 17-21 acetic anhydride used in production of, 1 158... 

Acetaminophen (APAP, N-acetyl-p-aminophenol) (Tylenol, other generic)... 

Acetaminophen (APAP, N-Acetyl-p-Aminophenol) (Tylenol, Other Generic) [OTC] [Analgesic, Antipyretic] Uses Mild-mod pain, HA, fever Action Nonnarcotic analgesic X CNS synth of prostaglandins hypothalamic heat-regulating center Dose Adults. 650 mg PO or PR q4-6h or... 

AMS acute myocardial syndrome ANC absolute neutrophil count ANS autonomic nervous system APACHE Acute Physiologic and Chronic Health Evaluation ICU illness severity scoring system APAP acetaminophen [N-acetyl-p-aminophenol] aPTT activated partial thromboplastin time ARB angiotensin II receptor blocker ARDS adult respiratory distress syndrome... 

Tylenol CH3CONHC6H4OH N-acetyl-p-aminophenol (acetaminophen, APAP) colourless, slightly bitter crystals can be toxic if an overdose is taken pain reliever (analgesic)... 

SYNS ABENSANIL ACAMOL ACETAGESIC ACETALGIN p-ACETAMIDOPHENOL 4-ACETAMIDOPHENOL ACETAMINOPHEN p-ACETAMINOPHENOL N-ACETYL-p-AMINOPHENOL... 

Acetaminophen (N-acetyl-p-aminophenol, paracetamol) is an analgesic marketed under a variety of brand names including Tylenol , Calpol , and Panadol . Preparation of the API is described in U.S. 2,998,450 (to Warner Lambert). U.S. 4,474,985 (to Monsanto) describes a process for improving product quality and shelf life. U.S. 5,856,575 (to Council of Scientific Industrial Research) describes an alternative process. Estimate the cost of production by each route. 

Synonyms APAP 4 -Hydroxyacetanilide p-Hy-droxyacetanilide Acetamide N-(4-hydroxyphenyl) N-Acetyl-p-aminophenol N-Acetyl-p-aminophe-nol p-Acetamidophenol 4-Acetamidophenol 4-Acetaminophenol Paracetamol Tylenol Chemical/Pharmaceutical/Other Class Acetaminophen is a synthetic nonopioid congener of acetanilide in the p-aminophenol class Chemical Eormula C8H9NO2... 

Phenazopyridine is absorbed through the gastrointestinal tract. It is metabolized rapidly, producing aniline, 2,3,6-triaminopyridine, p-aminophenol, and N-acetyl-/7-aminophenol. Renal clearance is the major route of elimination. Approximately 90% of a therapeutic dose is excreted in the urine within 24 h, with 41% as phenazopyridine, 24% as p-amino-phenol, 18% as N-acetyl-p-aminophenol, and 6.9% as aniline. The color of the urine changes to orange or red. 

Chemical Name Identifies the medication s chemical elements and compounds and used by scientists who work at the chemical level of the medication. For example, N-acetyl-p-aminophenol. 

B. Aniline Derivatives - A structure-activity study of a new series of alkoxyaniline derivatives has been reported along with a detailed workup of one of them . This compound (XII) appears to have good analgesic and anti-inflammatory activity, associated with some CNS depressant effects. An antidiuretic effect was described for acetaminophen 9 a d it was suggested that this drug might be a useful substitute for vasopressin in certain patients with diabetes insipidus. Evidence was also presented to show that acetophenetidin has antipyretic activity which is not dependent on metabolism to N-acetyl-p-aminophenol. 

The interesting observation that the analgesic acetaminophen (N-acetyl-p-aminophenol) accelerates net water flow across the Isolated toad bladder led to its trial in patients with diabetes insipidus.a single dose (1.2 to 2,k g.) produced a marked fall in urinary excretion and a rise in osmolality. It was suggested that acetaminophen may be a useful substitute for vasopressin in diabetes inslpidxis. 

Welch RM, Conney AH, Burns JJ. 1966. The metabolism of acetophenetidin and n-acetyl-p -aminophenol in the cat. Biochem Pharmacol 15 521-531. 

Each dose of a nighttime cold medicine contains 1000 mg of the analgesic acetaminophen. Acetaminophen, or N-acetyl-p-aminophenol, has the general formula CgHgNO. 

Abbreviations NAPAP= N-acetyl-p-aminophenol (the main metabolite of phenacetin) ns= not significant. 

D. G. Pope and J. L. Lach, Diffuse reflectance On its quantitative application to N-acetyl-p-aminophenol excipient-induced degradation, Can. J. Pharm. Sci. 10, 114-121(1975). 

ACETAMINOPHEN AND ACETAMINOPHEN WITH CODEINE PHOSPHATE (N-Acetyl-P-Aminophenol, APAP, Acephen, Anacin-3, Bromo-Seltzer, Datril, Datril 500, Tempra, Tylenol, Valadol, Valorin)... 

A stilbene polymer (Gn-3) isolated from Gnetum parvifolium inhibited the development of liver injury in mice caused by CCl4j N-acetyl-P-aminophenol (APAP) and Bacillus Calmette-Guerin (BCG) plus bacterial lipopolysaccharide (LPS) at a dose of 50 mg-kg d 1 sc administered for 3 d thus Gn-3 was found to have liver protective effects [74]... 

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