Mutagens environmental chemical

Adams JE. 1978. Mutagenicity of some environmental chemicals in salmonella test systems without microsomal activation. Mutat Res 53 142-143. 

Basak, S. C., Gute, B. D., Grunwald, G. D. Relative effectiveness of topological, geometrical, and quantum chemical parameters in estimating mutagenicity of chemicals. In Quantitative Structure—Activity Relationships in Environmental Sciences VII, Chen, F., Schuurmann, G., Eds., SETAC Press, Pensacola, EL, 1998, pp. 245-261. 

EPA. 1984a. In vitro and in vivo mutagenicity studies on environmental chemicals Research Triangle Park, NC Health Effects Research Laboratory, U.S. Environmental Protection Agency. EPA- 600/1 -84- 003. PB84-138973. 

TABLE I. Mutagenic Potency for Some Environmental Chemicals in the Salmonella/Microsome Test... 

Farmer P Committee on Mutagenicity of Chemicals in Food, Consumer Products and the Environment ILSl/HESl research programme on alternative cancer models results of Syrian hamster embryo cell transformation assay. International Life Sciences Institute/Health and Environmental Science Institute. Toxicol Pathol 2002 30 536-8. 

Lofroth, G, Nilsson, L. Andersen, J.R. (1986) Stracture-activity relationship of nitroalkane-induced mutagenicity in the Ames Salmonella assay. Genetic toxicology of environmental chemicals, Part B Genetic effects and applied mutagenesis. Prog. din. biol. Res., 209B, 149-155... 

Before 1960 it was generally believed that most drugs and other environmental chemicals were pharmacologically active, toxi( carcinogenic, andAir mutagenic in their parent (nonmetabolized) form. The... 

Kada, T., Hirano, K. Shirasu, Y. (1980) Screening of environmental chemical mutagens by the... 

W.W. Weber, Influence of Heredity on Human Sensitivity to Environmental Chemicals , Environ. Mol. Mutagen., 25(Suppl.), 102-114 (1995). 

Chapter 6 described methods for estimating the increase in the rate of dominant mutations from environmental chemicals on the basis of data on skeletal defects and cataracts in the mouse and estimates of the fraction of all severe human diseases that affect the skeleton or cause cataracts. Thus, we are in a position to make a tenuous estimate of the percentage by which the rate of human dominant mutation would be increased by some environmental mutagen. If penetrance is complete, the mutant genes will be expressed in the next and in ensuing generations until (as described in Chapter 3) they are eliminated by a decrease in the survival or fertility of their carriers. 

Kada, T., K. Hirano, and Y. Shirasu. Screening of environmental chemical mutagens by the Rec-assay system with Bacillus subtilis, pp. 149-173. In F.J. de Serres and A. Hollaender, Eds. Chemical Mutagens Principles and Methods for Their Detection. Vol. 6. 

Collective action frames tend to be loose and relatively informal sets of ideas, rather than formal ideological systems, because they need to be flexible in order to adapt to changing situations (Tarrow 1992 190). Chemical Risk provided a broad range of concerns from which scientist-activists could draw selectively and elaborate in papers and public presentations before policy makers, their research peers, university administrators, and high school biology classes. Accordingly, one could frame the problem of environmental chemical mutagens with equal flair as an economic burden, a moral dilemma, or a natural disaster. 

International Symposium on New Developments in Mutagenicity Testing of Environmental Chemicals... 

Symposium, The Role of Metabolic Activation in Producing Mutagenic and Carcinogenic Environmental Chemicals, February 9-11 Research Triangle Park, N.C. 

Prival, Michael J., and Vicki L. Dellarco, 1989. Evolution of social concerns and environmental policies for chemical mutagens. Environmental and Molecular Mutagenesis... 

ROBERT SHAPIRO is professor emeritus and senior research scientist in the Department of Chemistry at New York University. His research has centered on the chemistry of nucleic acids, with emphasis on the reactions of DNA and RNA with carcinogens and mutagens. Dr. Shapiro is author or co-author of over 110 publications, primarily in the area of DNA chemistry. In particular, he and his co-workers have studied the ways in which environmental chemicals can damage our hereditary material, causing changes that can lead to mutations and cancer. 

Basak, S.C., Gute, B.D. and Grunwald, G.D. (1998). The Relative Effectiveness of Topological, Geometrical and Quantum Chemical Parameters in Estimating Mutagenicity of Chemicals. In QSAR in Environmental Sciences - Vol. VII (Chen, F. and et al., eds.), SETAC Press, Pensacola (FL), pp. 245-261. 

Yamamoto KN, Hirota K, Kono K, Takeda S, Sakamuru S et al (2011) Characterization of environmental chemicals with potential for DNA damage using isogenic DNA repair-deficient chicken DT40 cell lines. Environ Mol Mutagen 52 547-561... 

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