Mutagenicity assay typhimurium

Simon, V.F. 1979a. In vitro mutagenicity assays of chemical carcinogens and related compounds with Salmonella typhimurium. J. Natl. Cancer Inst. 62 893-899. 

Dunkel VC, Zeiger E, Brusick D, et al. 1985. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogen and noncarcinogens in Salmonella typhimurium and Escherichia coli. Environ Mutagen (SuppI 5) 7 1-248. 

Anderson D. 1976. Paradichlorobenzene Estimation of its mutagenic potential in the Salmonella typhimurium plate incorporation mutagenicity assay. ICI Report No. CTL/P/298. November. 

Propionic acid does not appear to be geno-toxic. In vitro mutagenicity assays with propionic acid, using Salmonella typhimurium or Saccharcmyces cerevisiae, were negative with or without metabolic activation. ... 

Dunkel, V.C., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H.S. Simmon, V.F. (1984) Reproducibility of microbial mutagenicity assays I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Etrviron. Mutag., 6 (Suppl. 2), 1-254... 

The modified Ames mutagen assay was used to investigate the mutagenic potential of nitrosated fru-trp, a fru-trp control, and a nitrite control incubated in solutions under mild conditions (37°C, pH 4, 24 h). Figure 1 shows dose response curves obtained with S. typhimurium TA98 and TA100. Nitrosated fru-trp demonstrated a positive dose-response relationship with both tester strains in the absence of S-9 mix and a somewhat reduced dose-response relationship in its presence. The fru-trp and nitrite controls did not manifest mutagenic properties in either tester strain. 

Hye-Won A, Jeffrey EH. 1994. Effect of aluminum on fluoride uptake by salmonella typhimurium TA98 implications for the Ames mutagenicity assay. J Toxicol Environ Health 41 357-368. 

Cote C, Blaise C, Delisle CE, et al. A miniaturized Ames mutagenicity assay employing bioluminescent strains of Salmonella typhimurium. Mutat Res. 1995,345(3-4) 137-146. 

Azathioprine gave positive results in the Ames Salmonella typhimurium mutagenicity assay, both with and without metabolic activation, in the TAIOO strain. Negative results were found for the TA98 strain under similar test conditions. Azathioprine has been shown to induce chromosomal aberrations in human and rabbit lymphocytes in vitro, however, it did not induce sister chromatid exchanges in either... 

In vitro studies have demonstrated the mutagenic activity of nitrosamines. For example, mutagenicity assays using dimethylnitrosamines have been positive for Salmonella typhimurium, Escherichia coli, and Neurospora crassa. Dimethylnitrosamine also produced mitotic recombination in Salmonella cerevis-iae, recessive lethal mutations in Drosophila melanogaster, and chromosomal aberrations in mammalian cells. 

Ruiz-V6squez, R., Pueyo, C., and Cerdft-Olmedo, E., A mutagen assay detecting forward mutations in an arabinose-sensitive strain of Salmonella typhimurium. Mutation Res. 54 121-129 (1978). 

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