Mutagenesis damage

Touati D, M Jacques, B Tardat, L Bouchard, S Despied (1995) Lethal oxidative damage and mutagenesis are generated by iron Afur mutants of Escherichia coli protective role of superoxide dismutase. J Bacterial 111 2305-2314. 

Brcimer, L.H. (1990). Molecular mechanisms of oxygen radical carcinogenesis and mutagenesis. The role of DNA base damage. Mol. Carcinogen. 3, 188-197. 

Dedon, P. C. Plastaras, J. P. Rouzer, C. A. Marnett, L. J. Indirect mutagenesis by oxidative DNA damage formation of the pyrimidopurinone adduct of deoxyguanosine by base propenal. Proc. Natl. Acad. Sci. USA 1998, 95, 11113-11116. 

Chen, L. and Dixon, K., Analysis of repair and mutagenesis of chromium induced DNA damage in yeast mammalian cells and transgenic mice, Environmental, Health Perspective, 106, 1027-1032, 1998. 

Induced mutagenesis in Escherichia coli is an active process involving proteins with DNA replication, repair, and recombination functions. The available evidence suggests that mutations are generated at sites where DNA has been damaged and that they arise via an error-prone repair activity. In an attempt to understand what specific contributions to mutagenesis are made by DNA lesions, we have studied the mutational specificity of some carcinogens, such as benzo[a]pyrene and aflatoxin, whose chemical reactions with DNA are... 

In this chapter I will review some aspects of mutagenesis mechanisms and the mutational consequences of DNA damage generated by ben-zo[a]pyrene. The focus will be on knowledge derived from investigations involving the bacterium Escherichia coli. 

Mutations in either recA or lexA can abolish the SOS-response and eliminate both W-reactivation and W-mutagenesis. These mutations also eliminate the mutability of the bacteria by UV-irradiation (16) The observation that UV mutagenesis depended on the SOS-response established that mutations were not inevitable outcomes of DNA damage and that DNA damage required processing by cellular mechanisms in order for mutations to be recovered. What specific processes regulated by the SOS-response are responsible for mutagenesis ... 

Monomethylhydrazine-induced mutagenesis was not observed in Ames Salmonella/ microsome with activation (Matheson et al. 1978). In vivo tests in mice (dominant lethal, revertants in host-mediated assay), and dogs (micronuclei) were negative (reviewed in Trochimowicz 1994). However, in vitro chromosomal damage in human and rat tissue has been demonstrated, although in vivo liver DNA damage (as determined by DNA alkaline elution) was equivocal (reviewed in Trochimowicz 1994). 

Evans, H.H. 1990. Ionizing radiation mutagenesis in mammalian cells. Pages 211-219 in UCLA Symposia Colloquium. Ionizing Radiation Damage to DNA Molecular Aspects. Wiley-Liss, New York. 

Walker, G.C. (1984). Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia colt Microbiol. Rev. 48 60-93. 

Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation. Nature 2003, 425, 188-91. 

Portugal J, Waring MJ (1987) Interaction of nucleosome core particles with distamycin and echinomycin analysis of the effect of DNA sequences. Nucleic Acids Res 15(3) 885-903 Povirk LF, Goldberg IH (1987) A role of oxidative DNA sugar damage in mutagenesis by neocarzino-statin and bleomycin. Biochimie 69(8) 815-823... 

A. J. Jolly, C. P. Wild and L. J. Hardie, Acid and bile salts induce DNA damage in human oesophageal cell lines, Mutagenesis, 2004, 19(4), 319. 

C. Cherbonnel-Lasserre and M. K. Dosanjh, Suppression of apoptosis by over-expression of Bcl-2 or Bcl-xL promotes survival and mutagenesis after oxidative damage, Biochimie, 1997, 79(9-10), 613. 

Canonero R, Campart GB, Mattioli F, et al. 1997. Testing of p-dichlorobenzene and hexachlorobenzene for their ability to induce DNA damage and micronucleus formation in primary cultures of rat and human hepatocytes. Mutagenesis 12(l) 35-9. 

A. Single-base substitutions may occur as a result of DNA damage, chemical mutagenesis, or unrepaired errors in replication. 

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