Sugar Damage

Portugal J, Waring MJ (1987) Interaction of nucleosome core particles with distamycin and echinomycin analysis of the effect of DNA sequences. Nucleic Acids Res 15(3) 885-903 Povirk LF, Goldberg IH (1987) A role of oxidative DNA sugar damage in mutagenesis by neocarzino-statin and bleomycin. Biochimie 69(8) 815-823... 

Three of the deoxyribose carbon centered radicals, dRib(C3 -H), dRib(C4 -H), and dRib(C5 -H), give rise to prompt SSB via a phosphate elimination reaction. The strand break mechanism for the dRib(CI -H) radical differs substantially. Like the three radicals above, it will release a free unaltered base but instead of forming a strand break, a subsequent one-electron oxidation results in deoxyribonolactone (dRibonoLac) formation (Fig. la) [1,18].This abasic site is quite stable. Heat and a catalyst, such as spermine, turn this lesion into a strand break plus 5-methylenefuranone (SMFur) [18]. The later is a signature end product of Cl sugar damage. 

Table 6. Inhibition of Lipid Peroxidation (Chemiluminescence and TBARS) and Free Radical-mediated DNA-sugar Damage Induced by the Presence of Fe (II) Salts (IC5o s) in Methanolic Extrncts and Isolated Compounds of Pothomorphe spp.

Chin DH, Kappen LS, Goldberg IH. 3 -Formyl phosphate-ended DNA high-energy intermediate in antibiotic-induced DNA sugar damage. Proc Nat Acad Sci USA. 1987 84 7070-7074. 

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