Muscle fatty acid

The ability of NOE matching to identify the correct pose from a collection of decoy poses was demonstrated on three test cases involving lead-like compounds bound to small proteins. One of these test cases involves muscle fatty acid-binding protein (mFABP) and the other two involve the leukocyte function-associated antigen 11-domain (LFA-1). As these results have been presented in detail elsewhere,1151 here we only summarize the results obtained when the BMRB average chemical shifts (diamagnetic protein statistics) were used for chemical shift predictions. The compounds used for these test cases are shown in Scheme 5.1 (compound 3 contains a proprietary core, which is represented by an ellipse). 

In the capillaries of adipose tissue and muscle, fatty acids of chylomicrons are removed from the triacylglycerols hy the action of lipoprotein lipase (LPL) LPL is present on the surface of the endothehal cells of the capillaries. Chylomicron apo-C-II activates LPL in the presence of phospholipid. 

Muscle fatty acid binding protein Orthorhombic 222 P2i2i2i 35.4 56.7 72.7 90 90 90... 

For better characterization and understanding of meat characteristics, the potential of NMR spectroscopy and imaging has been illustrated." Authors demonstrate the energy metabolites in muscle, fatty acid components of animal fat, a quantitative measurement of parameters closely correlated with meat properties such as pH, cooking yield and water holding capacity at each point of an NMR imaging and so on. It is concluded that NMR is a powerful tool for meat research in comparison with other less expensive techniques. 

U nknown Tamoxifen, diethylstilbestrol (ERRy) Muscle fatty acid metabolism (ERRi... 

In resting muscle, fatty acids represent the major energy source during exertion, glucose is the primary source. Early in a period of exertion, glucose comes from mobilization of the muscle s glycogen reserves. 

VyV thesize malonyl-CoA for fatty acid synthesis. Muscle cells do not synthesize fatty acids however, they do carefully regulate the oxidation of fatty acids through the synthesis and destruction of malonyl-CoA. ACC-1 is a cytosolic protein, whereas ACC-2 is mitochondrial, closely linked to CPT-I in the outer mitochondrial membrane. Mice that have been bred to lack ACC-2 have a 50% reduction of fat stores as compared with "normal" mice. This was shown to be attributable to a 30% increase in skeletal muscle fatty acid oxidation because of the dysregulation of CPT-I, because malonyl CoA could not be produced to regulate the rate at which fatty acid oxidation occurred. 

Additional information <2, 6> (<6> enzyme functions as a metabolic sensor that monitors cellular AMP and ATP levels [31] <2> phosphory-lates key target proteins that control flux through metabolic pathways of hepatic ketogenesis, cholesterol synthesis, adipocyte lipolysis and skeletal muscle fatty acid oxidation [30] <4> regulates triacylglycerolsynthesis and fatty acid oxidation in liver and muscle reciprocally [29]) [29-31]... 

Bell, J.G., Henderson, R.J., Tocher, D.R., McGhee, F., Dick, J.R., Porter, A., Smullen, R.P. and Sargent, J.R. (2002). Substituting fish oil with crude palm oil in the diet of Atlantic salmon (Salmo salar) affects muscle fatty acid composition and hepatic fatty acid metabolism. Journal of Nutrition, 132, 222-230. 

Ng, W.K., Lim, P.K. and Sidek, H. (2001). The influence of a dietary lipid source on growth, muscle fatty acid composition and erythrocyte osmotic fragility of hybrid tilapia Fish Physiology and Biochemistry, 25, 301 -310. 

Teye, G.A., Sheard, P.R., Whittington, F.M., Nute, G.R., Stewart, A. and Wood, J.D. (2006) Influence of dietary oils and protein level on pork quality. 1. Effects on muscle fatty acid composition, carcass, meat and eating quality. Meat Science, 73,157-165. 

Torstensen, B.E. Froyland, L. 0rnsrud, R. Lie, O. (2004). Tailoring of a cardioprotective muscle fatty acid composition of Atlantic salmon (Salmo salar) fed vegetable oils. Food Chemistry, Vol.87, No.4, (Octomber 2004), pp. 567-580, ISSN 0308-8146 Torstensen, B.E. 0yvind, L. Froyland, L. (2000). Lipid metabolism and tissue composition in Atlantic salmon Salmo salar L.) - Effects of capelin oil, palm oil, and oleic acid-enriched sunflower oil as dietary lipid sources. Lipids, Vol.35, No.6, (June 2000), pp. 653-664, ISSN 0024-4201... 

Rule, D. C., Broughton, K. S., Shelhto, S. M., Maiorano, G. (2002). Comparison of muscle fatty acid profiles and cholesterol concentrations of bison, beef cattle, eUc, and chicken. Journal of Animal Science, 80, 1202-1211. 

Bessa RJB, Aves SP, Jerbnimo E, Alzaia CM, Prates JAM, Santos-SUva J (2007) Effect of Upid supplements on mminal biohydrogenation intermediates and muscle fatty acids in lamb. Eur J... 

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