Murine melanoma model

ECso = 3.7nM) demonstrated balanced potency and pharmacokinetic (absorption, distribution, metabolism, excretion, toxicity (ADMET)) profiles. In addition, compound 73 exhibited potent oral in vivo efficacy in potentiating the cytotoxic agent temozolomide in a B16F10 murine melanoma model. 

Castleden SA Chong H, Garcia-Ribas I, Melcher AA Hutchinson G, Roberts B, Hart IR, Vile RG. A femily of hicistronic vectors to enhance both local and systemic antitumor effects of HSV/ or cytokine expression in a murine melanoma model. Hum Gene Ther 1997 8 2087 2102. 

Parker, S. E., Khatibi, S., Margalith, M., Anderson, D., Yankauckas, M Gromkowski, S. H., Latimer, T Lew, D., Marquet M Manthorpe M., Hobart, P., Hersh, E., Stopeck, A. T and Norman, J. (1996) Plasmid DNA gene therapy studies with the human interleukin-2 gene in tumor cells in vitro and in the murine B16 melanoma model in vivo. Cancer Gene Ther. 3(3), 175-185. 

Apart from the sympathomimetic effects of ephedra, a few studies probed its other possible effects. In a herb-acupuncture study, the water distillate of E. sinica was effective in reducing the inflammatory responses of arthritis, both in vitro and in a rat model. An aqneous fraction of E. sinica, at 30 ig/kg/day, exhibited anti-invasive and antian-giogenic activities in murine melanoma cells and in human umbilical venous endothelial cells, respectively. The same fraction also inhibited the growth of a melanoma cell mass in mice in comparison to adrimaycin. ... 

Preliminary in vitro and animal studies of the effects of silymarin and silybinin have been carried out with several cancer cell lines. In murine models of skin cancer, silybinin and silymarin were said to reduce tumor initiation and promotion. Induction of apoptosis has also been reported using silymarin in a variety of malignant human cell lines (eg, melanoma, prostate, leukemia cells, bladder transitional-cell papilloma cells, and hepatoma cells). Inhibition of cell growth and proliferation by inducing a Gx cell cycle arrest has also been claimed in cultured human breast and prostate cancer cell lines. The use of milk thistle in the clinical treatment of cancer has not yet been adequately studied but preliminary trials are under way. 

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