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Muramyl peptides

Drugs (e.g., polynucleotides [e.g., polyriboinosinic polyribocytidylic acid], antitumor agents [e.g., bleomycin], plant alkaloids [e.g., colchicine], synthetic immunoadjuvants [e.g., muramyl peptides]... [Pg.501]

Pappenheimer, JR (1983) Induction of sleep by muramyl peptides. J. Physiol. 336 1-11. [Pg.498]

Krueger, J. M., Pappenheimer, J. R. Karnovsky, M. L. (1982). Sleep-promoting effects of muramyl peptides. Proc. Natl. Acad. Sci. USA 79, 6102-6. [Pg.332]

Pathogens known to stimulate CSF production include Salmonella typhi-murium, Mycobacterium lepraemurium, Brucella abortus and Schistosoma mansonii. Additionally, non-viable bacteria or bacterial products, such as Nocardia rubra cell-wall fragments, muramyl peptides and bacterial endotoxins, can also induce CSF production. [Pg.49]

VM Titov, EA Meshcheryakova, TA Balashova, TM Andronova, VT Ivanov. Synthesis and immunological evaluation of the conjugates composed from muramyl peptide GMDP and tuftsin. (Z-Thr-ONSu) Int J Pept Prot Res 45, 348, 1995. [Pg.163]

Another controversial but exciting area of research is the potential role of serotonin in sleep. 5-Hydroxytryptamine may trigger slow-wave sleep (non-REM sleep), whereas the muscarinic AChR and NE are involved in REM sleep (rapid-eye-movement sleep, paradoxical sleep, dream sleep). In addition to the aminergic regulation of sleep, recent research has identified several other presumed sleep factors delta-sleep-inducing peptide, sleep-promoting substance, interleukin-1, and muramyl peptides. [Pg.254]

J. M. Krueger (1985). Somnogenic activity of muramyl peptides. Trends Pharmacol. Sci. 6 218-221. [Pg.304]

The influence of physicochemical properties of liposomes, such as charge density, membrane fluidity, and epitope density, on the immune response elicited by antigens has been extensively studied [37]. In addition to antigens, other immune stimulators that are amphoteric muramyl peptides or lipid-soluble compounds, such as monophosphoryl lipid A or muramyl tripeptidyl-phosphatidylethanolamine, can also be incorporated into liposomes to increase their adjuvant effect in eliciting immune responses [34]. [Pg.361]

Early in the 20th century, Pierin in Paris infused the CSF of sleep-deprived dogs into normal dogs and showed that the CSF contained a sleep-inducing (somnogenic) factor. This was thought to be a muramyl peptide but later suggested to be the result of bacterial contamination as these peptides cannot be synthesized by the mammalian brain. [Pg.452]

Geert-Jan Boons et al. also synthesized peptidoglycan fragments such as the disaccharide repeating unit [51] and muramyl peptide derivatives containing Lys and DAP residues [52-55] obtained through cross olefin metathesis [56], The muramyl peptides, such as 48 prepared by solid-phase synthesis on Sieber amide resin (Scheme 14.6), were subjected to biological and structural analyses [50, 57, 58] of... [Pg.368]

The muramyl peptides (MP) of the bacterial cell walls are polymeric chain molecules composed of N-acetylglucosamine and N-acetylmuramic acid, each carrying a peptide side chain and crosslinked with one another (Fig. 8). The N-terminal D-Ala residues of the side chains are bound covalently to the peptide side chains of neighboring polysaccharide chains via pentaglycine units. [Pg.131]

Muramyl peptides can be used as adjuvants in combination with vaccines (increasing the humoral and cellular immunity) or with antibiotics (increasing the antibacterial effect). [Pg.131]

Numerous analogs of the muramyl peptide factor 153 13+1 have been synthesized with a view to finding endogenous hypnotics that do not lead to dependence. [Pg.133]

Seyler, I. Appel, M. Devissaguet, J.P. Legrand, P. Barratt, G. Relationship between NO-synthase activity and TNF-alpha secretion in mouse macrophage lines stimulated by a muramyl peptide entrapped in nanocapsules. Int. J. Immunopharmacol. 1996, 18, 385-392. [Pg.1199]

Glycopeptides substances of low molecular weight having many of the physical properties of a peptide, but containing covalently bonded carbohydrate components) mucopeptides, mucins muramyl peptides, products of enzymic degradation of glycoproteins... [Pg.437]

Contents P. LEFRANCIER and E. LEDERER Chemistry of Synthetic Immunomodulant Muramyl Peptides. — SUKH DEV The Chemistry of Longifolene and Its Derivatives. — W. HELLER and CH.TAMM Homoiso-flavanones and Biogenetically Related Compounds. — R. G. COOKE and J. M. EDWARDS Naturally Occurring Phenalenones and Related Compounds. — C. W. JEFFORD and P. A. CADBY Molecular Mechanisms of Enzyme-Catalyzed Dioxygenation (An Interdisciplinary Review). [Pg.255]

This section deals exclusively with the synthesis of MDP (1) itself (20, 30, 33, 35, 44, 50). Details of earlier preparations of N-acetyl-muramyl-peptides (5, 8, 39), although dealing with analogues of MDP, are mentioned occasionally. [Pg.4]

In the synthesis of N-acetyl-muramyl-peptides, and obviously of MDP, the most frequently used protected muramyl derivative is 1-O-benzyl-4,6-O-benzylidene-N-acetyl-muramic acid. This allows the mild and possibly simultaneous elimination of the benzylidene group and the benzyl group. Starting from D-glucosamine, either a- or p-benzyl-4,6-0-benzylidene-N-acetyl-muramide can be obtained (Fig. 4) 17, 25, 53). In spite of its slower hydrogenolysis rate 44), the a-isomer which is easier to prepare is generally preferred (55, 44) to the p-isomer 50). [Pg.5]

Several different metltods were used to couple muramic acid with the peptide moiety. In the first synthesis of MDP, N-ethyl-5-phenyl-is-oxazolium-3 -sulfonate (Woodward s reagent K) was used (50). This condensing reagent had been applied in earlier preparations of various N-acetyl-muramyl-peptides (8, 39). A mixture of acetonitrile-dimethyl-formamide (2 1), is used as solvent but the protected muramic acid derivative is poorly soluble and the reaction does not always proceed well. [Pg.7]

Chemistry of Synthetic Immunomodulant Muramyl Peptides 1. CS2CO3... [Pg.13]


See other pages where Muramyl peptides is mentioned: [Pg.495]    [Pg.316]    [Pg.316]    [Pg.363]    [Pg.516]    [Pg.568]    [Pg.110]    [Pg.131]    [Pg.65]    [Pg.16]    [Pg.83]    [Pg.3]    [Pg.5]    [Pg.7]    [Pg.9]    [Pg.11]    [Pg.15]    [Pg.17]    [Pg.19]    [Pg.19]    [Pg.21]    [Pg.21]   
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See also in sourсe #XX -- [ Pg.49 ]

See also in sourсe #XX -- [ Pg.6 , Pg.385 , Pg.404 ]

See also in sourсe #XX -- [ Pg.6 , Pg.385 , Pg.404 ]

See also in sourсe #XX -- [ Pg.296 , Pg.297 ]




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Muramyl peptides (Factor

Muramyl peptides, immunomodulant

N-Acetyl-muramyl-peptides

Synthesis muramyl peptide

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