Delta sleep-inducing peptide

Other than adenosine, there are several peptides which induce sleep (e.g., delta sleep inducing peptide). Together with endogenous chemicals interacting with the GABA benzodiazepine receptor site (e.g., (3-carbolines) identified in... 

Another controversial but exciting area of research is the potential role of serotonin in sleep. 5-Hydroxytryptamine may trigger slow-wave sleep (non-REM sleep), whereas the muscarinic AChR and NE are involved in REM sleep (rapid-eye-movement sleep, paradoxical sleep, dream sleep). In addition to the aminergic regulation of sleep, recent research has identified several other presumed sleep factors delta-sleep-inducing peptide, sleep-promoting substance, interleukin-1, and muramyl peptides. 

Chiang CH, Shao CH, and Chen JL. Effects of pH, electric current and enzyme inhibitors on iontophoresis of delta sleep-inducing peptide. Drug Dev. Ind. Pharm. 1998 24 431M-38. 

Deltanyne dronabinol, delta sleep-inducing peptide (DSIP) is a nonapeptide, originally isolated from the extracorporeal dialysate of cerebral venous blood of rabbits, and subsequently was synthesized. It induces sleep when administered intravenously in animal models. It can cross the blood-brain-barrier and has ANTICONVULSANT and HYPNOTIC actions it also inhibits pituitary ACTH secretion. Deltasone prednisone. 

Sazontova TG, Golantsova NE. Kolmykova SN, Arkhangel Skaia MI, Koshatskaia IL, Arkhipenko. Effect of delta sleep-inducing peptide on the status of the calcium transport system of the sarcoplasmic reticular and activity of antioxidant defense enzymes in the myocardium. Bull Exp Biol Med 1996 121 248-251. 

Delta sleep inducing peptide (DSIP) E,K (total) [223]... 

It has been duly observed that the endogenous peptide sleep substances in particular seem to regulate the prevailing neuronal activity which are direetly linked with the phenomenon of sleep. Delta-sleep-inducing peptide (DSIP) is regarded to be the most widely known CNS-peptide that has been proved to be directly associated with the sleep regulatory phenomenon. It has been established experimentally that the dialysate meticulously derived from the cerebral blood of rabbits, which were... 

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