Immunomodulator, synthetic

Since the pioneer work by Merigan in 1967 [1], many kinds of synthetic or natural polyanionic polymers have been examined for their biological activities [2-8], such as cytotoxicity, antiviral activity, antitumor activity, and immunomodulating activity. Although the biological results were interesting, the extent of activity for clinical application was still low. 

Lacroix, I., Biton, J. and Azerad, R. (1997) Microbial biotransformation of a synthetic immunomodulating agent, HR325. Bioorganic and Medicinal Chemistry, 5, 1369-1380. 

Brynestad K, et al. Influence of peptide acylation, liposome incorporation, and synthetic immunomodulators on the immunogenicity of a 1-23 peptide of glycoprotein D of herpes simplex virus implications for subunit vaccines. J Virol 1990 64 680. 

Low-molecular-weight antagonists are attractive due to their low cost and bioavailability. Available literature indicates that many laboratories are attempting to create immunomodulators of small synthetic molecules, peptidomimetics, bacterial cell-wall components, macrocycles, corticosteriods, and others [74]. 

Melatonin N-acetyl-5- methoxytryptamine Manufactured synthetically to mimic the endogenous hormone Sedative-hypnotic regulate sleep-wake cycles used in various other conditions because of antioxidant and immunomodulating effects... 

S. Arimori, K. Watanabe, M. Yoshida and T. Nagao, in Immunomodulation by Microbial Product and Related Synthetic Compounds, Proc. Int. Symp., Amsterdam, 1981, pp. 536-539. 

Farghali H, Machkova Z, Kamenikova L, et al. 1984. The protection from hepatotoxicity of some compounds by the synthetic immunomodulator muramyl dipeptide (MDP) in rat hepatocytes and in vivo. Methods Find Exp Clin Pharmacol 6 449-454. 

Mitoxantrone] (anthraquinone) Synthetic Dansyl-CaM-FC (4) [anticancer drug, cytotoxic, immunomodulator]... 

Lysolecithin Analogs - The immunomodulating effects of a variety of synthetic lysolecithin analogs (58) have been reviewed. 59... 

Synthetic 5-peptide consisting of residues 32-36 of thymopoietin, an immunologically active polypeptide. It is an investigational drug used for its immunomodulating properties. 

Contents P. LEFRANCIER and E. LEDERER Chemistry of Synthetic Immunomodulant Muramyl Peptides. — SUKH DEV The Chemistry of Longifolene and Its Derivatives. — W. HELLER and CH.TAMM Homoiso-flavanones and Biogenetically Related Compounds. — R. G. COOKE and J. M. EDWARDS Naturally Occurring Phenalenones and Related Compounds. — C. W. JEFFORD and P. A. CADBY Molecular Mechanisms of Enzyme-Catalyzed Dioxygenation (An Interdisciplinary Review). 

Investigations on the actions of lipoxins in various cell types and in vivo, helped to establish these lipid mediators as immunomodulators that exhibit potent antiinflammatory and pro-resolving actions. In addition to reducing excessive and persistent inflammation, LXA4 and its synthetic stable analogs were the first molecules... 

Chemistry of Synthetic Immunomodulant Muramyl Peptides 1. CS2CO3... 

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