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Multiple myeloma case study

M3. McFarlane, H., Multiple myeloma in Jamaica A study of 40 cases with special reference to incidence and laboratory diagnosis. J. Clin. Pathol. 19, 268-271 (1966). [Pg.233]

A third case-control study suggested an association between an increased incidence of multiple myeloma and exposure to high concentrations of insecticides, including diazinon. Actual exposure to diazinon was reported in 2 (0.3%) of the cases and 5 (0.3%) of the controls (Morris et al. 1986). [Pg.30]

Morris PD, Koepsell TD, Dating JR, et al. 1986. Toxic substance exposure and multiple myeloma. A case-control study. J Natl Cancer Inst 76(6) 987-994. [Pg.202]

An increased risk for central nervous system and multiple myeloma was reported from a cohort study of workers exposed to 1,1,1-trichloroethane in Finland. These findings were not confirmed by two case-control studies carried out in the United States and Canada, while an increased risk for cancer of the lung and kidney was shown in the Canadian study. [Pg.896]

The Pliofilm cohort consisted of 1,868 individuals 1,044 worked at the St. Marys plant location from 1940 to 1975 and 824 at the Akron plant site from 1936 to 1965. This cohort was classified into two groups the wetside workers (1,291 workers) with direct benzene exposure and the dryside workers (577) with no direct benzene exposure. In the most recent update of these, NIOSH followed up the vital status of only the wetside workers through 1987. The updated vital status of the wetside workers from 1970 to 1981 resulted in the identification of an additional 123 deaths for a total of 481 deaths in the wetside subgroup. No new cases of multiple myeloma were reported. The results of this analysis support previous studies of this cohort. [Pg.95]

In a placebo-controlled study of severely anemic patients with low-grade non-Hodgkin s lymphoma, chronic lymphocytic leukemia, or multiple myeloma, a fatal case of pulmonary embolism was thought to have been related to treatment with epoetin beta (95). Thrombotic events, such as vascular access thrombosis, venous thrombosis, and pulmonary embolism, have occurred after treatment with epoetin or darbepoetin alfa (96). It is therefore recommended that a rapid rise in the hemoglobin concentration be avoided and that care should be taken that the hemoglobin concentration does not exceed 12.1 g/dl (7.5 mmol/1) (97). [Pg.1247]

A case-control study was performed in a cohort of 29,139 men employed in a chemical manufacturing environment (60). Nested case-control studies of non-Hodgkin s lymphoma, multiple myeloma, nonlymphocytic leukemia, and lymphocytic leukemia were conducted in men from two chemical facilities and a research center. Exposure odds ratios were examined in relation to 21 specific chemicals. The results are difficult to interpret because exposure to vinyl acetate was associated with a decreased risk for nonlymphocytic leukemia (odds ratio ... [Pg.506]

Speer, SA, Semenze JC, Kurosaki T, et al. Risk factors for acute myeloid leukemia and multiple myeloma A combination of GIS and case-control studies. J Environ Health 2002 64(7) 9—16. [Pg.116]

Flodin U, Fredriksson M, Persson B. 1987. Multiple myeloma and engine exhausts, fresh wood, and creosote a case-referent study. Am J Ind Med 12 519-529. [Pg.322]

Nicholls MG, Espiner EA. Indomethacin-induced azotaemia and hyperkalemia a case study. N Z Med J 1981 94 377-379. Paladini G, Tonazzi C. Indomethacin-induced hyperkalemia and renal failure in multiple myeloma. Acta Haematol 1982 68 256-260. [Pg.302]

In some cases occupational exposures to phthalates have been associated with adverse health effects. A case-control study among a population of Danish workers employed in PVC production for 5 years or greater demonstrated a significant increase in the risk of multiple myeloma.Phthalate mixtures containing BBP have been associated with respiratory or neurological effects and cancer,increased incidence of menstrual disorders, and spontaneous abortions. " A stutfy of college students with no known exposure to phthalates found a ne tive correlation between DBP concentration and sperm density or total number of sperm. - However, this study did not consider con-founders nor did it provide ample evidence for a causal relationship of sperm characteristics to DBP levels. There were no human health data available for DEHP, DIDP, DINP, DnHP, norDnOP. [Pg.563]

The 1994 cumulative study found 290 cases of leukemia along with 229 cases of lymphoma and 73 cases of multiple myeloma. The death rate from leukemia among bomb survivors was thirty times its normal level. [Pg.115]

The ultracentrifuge has found comparatively little application to the study of pathological sera. McFarlane (235) obtained sedimentation diagrams of the sera in patients with tuberculosis, pneumonia, scarlet fever, multiple myeloma, ovarian carcinoma, and other disorders, but the results proved difiUcult to interpret. He found evidence of an increase in globuhns in some of the infections and in one case of myeloma noted a large fraction (probably not the X-protein), intermediate in sedimentation rate between the A and G components. Interesting results have been obtained in multiple myeloma (162, 178, 233, 235, 251, 271) in efforts to identify Bence-Jones proteins in the blood and urine. Whereas typical Bence-Jones proteins obtained from the urine (235, 251,... [Pg.177]


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