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Multidrug modulator

Langer T, Eder M, Hoffmann RD, Chiba P and Ecker GF. Lead identification for modulators of multidrug resistance based on in silico screening with a phar-macophoric feature model. Arch Pharm (Weinheim) 2004 337 317-27. [Pg.511]

Chearwae, W. et al.. Modulation of the function of the multidrug resistance-linked ATP-binding transporter ABCG2 by the cancer chemopreventive agent curcumin. Mol. Cancer Then, 5, 1995, 2006. [Pg.146]

Limtraknl, P. et al.. Modulation of the function of three ABC drug transporters, P-glycoprotein (ABCBl), mitoxantrone resistance protein (ABCG2) and multidrug resistance protein 1 (ABCCl) by tetrahydroenrenmin, a major metabolite of cur-enmin. Mol. Cell Biochem., 296, 85, 2007. [Pg.146]

W. T., Physical-chemical properties shared by compounds that modulate multidrug resistance in human leukemic cells, Mol. Pharmacol. 1988, 33, 454-462. [Pg.489]

Romsicki, Y., Sharom, F. J., The membrane lipid environment modulates drug interactions with the P-glycoprotein multidrug transporter, Biochemistry 1999, 38, 6887-6896. [Pg.491]

As described in several monographs [4], bryostatin 1 exhibits significant in vitro and in vivo antineoplastic activity against a range of tumor cell lines including murine leukemia, B-cell lymphoma, reticulum cell sarcoma, ovarian carcinoma, and melanoma. It is also effective in the modulation of apoptotic function [5], the reversal of multidrug resistance [6], and stimulation of the immune system [7]. These unique features displayed by bryostatin 1 are attributed to its high affinity for protein kinase C (PKC) isozymes and its ability to selectively modulate their functions [8]. PKCs are a type of intracellular serine and threonine kinase that... [Pg.104]

Eytan, G.D., Regev, R., Oren, G. and Assaraf, Y.G. (1996) The role of passive transbilayer drug movement in multidrug resistance and its modulation. Journal of Biological Chemistry, 271, 12897-12902. [Pg.393]

Thimmaiah, K.N., Horton, J.K., Qian, X.D., Beck, W.T., Houghton, J.A. and Houghton, J. (1990) Structural determinants of phenoxazine type compounds required to modulate the accumulation of vinblastine and vincristine in multidrug-resistant cell lines. Cancer Communications, 2, 249-259. [Pg.394]

Dhainaut, A., Regnier, G., Atassi, G., Pierre, A., Leonce, S., Kraus-Berthier, L. and Prost, J.F. (1992) New triazine derivatives as potent modulators of multidrug resistance. Journal of Medicinal Chemistry, 35, 2481-2496. [Pg.394]

Ferte, J., Kuhnel, J.M., Chapuis, G., Rolland, Y., Lewin, G. and Schwaller, M. A. (1999) Flavonoid-related modulators of multidrug resistance synthesis, pharmacological activity, and structure-activity relationships. Journal of Medicinal Chemistry, 42, 478—489. [Pg.394]

Lo Y-L (2003) Relationships between the hydrophilic-lipophilic balance values of pharmaceutical excipients and their multidrug resistance modulating effect in Caco-2 cells and rat intestines. J Control Release 90 37 -8... [Pg.451]

J. Troost, H. Lindenmaier, W. E. Haefeli, and J. Weiss. Modulation of cellular cholesterol alters P-glycoprotein activity in multidrug-resistant cells. Mol. Pharmacol. 66 1332-1339 (2004). [Pg.613]

Cabot, M. C., Giulano, A. E., Han, T-Y., and Liu, Y-Y., 1999, SDZ PSC 833, the cyclosporin A analog and multidrug resistance modulator, activates ceramide synthesis and increases vinblastine sensitivity in drug-sensitive and drag-resistant cancer cells. Cancer Res. 59 880-885. [Pg.279]

Lucci, A., Han, T. Y., Liu, Y. Y., Giuliano, A. R, and Cabot, M. C., 1999b, Multidrug resistance modulators and doxorubicin synergize to elevate ceramide levels and elicit apoptosis in drug-resistant cancer cells. Cancer 86 299-310. [Pg.282]

Meissner, K., Jedlitschky, G., Meyer zu Schwabedissen, H., et al. (2004) Modulation of multidrug resistance P-glycoprotein 1 (ABCBl) expression in human heart by hereditary polymorphisms. Pharmacogenetics. 14, 381-385. [Pg.61]

Brooks T, Minderman H, O Loughlin KL, Pera P, Ojima 1, Baer MR, Bemacki RJ. (2003) Taxane-based reversal agents modulate drug resistance mediated by P-glycoprotein, multidrug resistance protein, and breast cancer resistance protein. Mol Cancer Ther 2 1195-1205. [Pg.169]

Ahmad S, Trepel JB, Ohno S, Suzuki K, Tsuruo T, Glazer R1 (1992) Role of protein kinase C in the modulation of multidrug resistance expression of the atypical gamma isoform of protein kinase C does not confer increased resistance to doxorubicin. Mol Pharmacol 42 1004-1009... [Pg.60]

Hu YP, Robert J (1997) Inhibition of protein kinase C in multidrug-resistant cells by modulators of multidrug resistance.) Cancer Res Clin Oncol 123 201-210... [Pg.75]

Matsumoto T, Tani E, Yamaura 1, Miyaji K, Kaba K (1995) Effects of protein kinase C modulators on multidrug resistance in human glioma cells. Neurosurgery 36 565-571... [Pg.81]

Regev R, Assaraf YG, Eytan GD (1999) Membrane fluidization by ehter, other anesthetics, and certain agents abolishes P-glycoprotein ATPase activity and modulates efflux from multidrug-resistant cells. Eur J Biochem 259 18-24... [Pg.87]

Sachs CW, Safa AR, Harrison SD, Fine RL (1995) Partial inhibition of multidrug resistance by safingol is independent of modulation of P-glycoprotein substrate activities and correlated with inhibition of protein kinase C. J Biol Chem 270 26639-26648... [Pg.88]

Sampson E, Wolff CL, Abraham I (1993) Staurosporine reduces P-glycoprotein expression and modulates multidrug resistance. Cancer Lett 68 7-14... [Pg.88]

Spitaler M, Utz I, Hilbe W, Hofmann J, Grunicke HH (1998) PKC-independent modulation of multidrug resistance in cells with mutant (V185) but not wild-type (G185) P-glycoprotein by bryostatin 1. Biochem Pharmacol 56 861-869... [Pg.90]

Hiessbock R, Wolf C, Richter E, Hitzler M, Chiba P, Kratzel M, Ecker G (1999) Synthesis and in vitro multidrug resistance modulating activity of a series of dihydrobenzopyrans and tetrahydroquinolines. J Med Chem 42 1921-1926... [Pg.64]

Bois, F. et al.. Synthesis and biological activity of 4-alkoxy chalcones potential hydrophobic modulators of P-glycoprotein-mediated multidrug resistance, Bioorg. Med. Chem., 1, 2691, 1999. [Pg.467]

In the framework of a synthesis of antimycobacterial agents, acid chloride 134 was reacted with 2-aminophenol 115 and base. The isolated product 135 underwent a base-mediated ring closure to form tricyclic benzoxazepines 136 (Scheme 18) <2000AP231>. The same procedure has been used for the synthesis of multidrug resistance modulating agents <2004JME4627>. [Pg.274]

See other pages where Multidrug modulator is mentioned: [Pg.752]    [Pg.489]    [Pg.493]    [Pg.26]    [Pg.286]    [Pg.23]    [Pg.367]    [Pg.379]    [Pg.392]    [Pg.365]    [Pg.198]    [Pg.147]    [Pg.252]    [Pg.40]    [Pg.43]    [Pg.46]    [Pg.47]    [Pg.60]    [Pg.71]    [Pg.74]    [Pg.83]    [Pg.545]    [Pg.11]    [Pg.19]   
See also in sourсe #XX -- [ Pg.351 ]



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