Multicenter cooperation

Methoxsalen is supplied in soft gelatin capsules (Oxsoralen-Ultra) and hard gelatin capsules (8-MOP). The dose is 0.4 mg/kg for the soft capsule and 0.6 mg/kg for the hard capsule taken 1.5 to 2 hours before UVA exposure. A lotion containing 1% methoxsalen (Oxsoralen) also is available for topical application. It can be diluted for use in bath water to minimize systemic absorption. The risk of phototoxicity is increased with topical PUVA therapy. In U.S. and European multicenter cooperative studies of PUVA for the treatment of psoriasis, initial clearance rates approaching 90% were achieved. Relapse occurs within 6 months of cessation of treatment in many patients, which has prompted efforts to design maintenance protocols. 

Fine, R.N., E.C. Kohaut, D. Brown, and A.J. Perlman, Growth after recombinant human growth hormone treatment in children with chronic renal failure report of a multicenter randomized double-blind placebo-controlled study. Genentech Cooperative Study Group. J Pediatr, 1994.124(3) 374-82. 

Chevret S., HemmerM., Carlet J., and LangerM. (1993) Incidence and risk factors of pneumonia acquired in intensive care units. Results from a multicenter prospective study on 996 patients. European Cooperative Group on Nosocomial Pneumonia. Intern. Care Med. 19, 256-264. 

The intramolecular events in the multicenter oxidases, which enable the functional cooperation of the different active sites in carrying out reduction or oxidation of specific substrates, notably those where multiple electron transfer steps are favored pathways... 

Aldenkamp AP, Baker G, Mulder OG, Chadwick D, Cooper P, Doelman J, Duncan R, Gassmann-Mayer C, de Haan GJ, Hughson C, Hulsman J, Overweg J, Pledger G, Rentmeester TW, Riaz H, Wroe S. A multicenter, randomized clinical study to evaluate the effect on cognitive function of topiramate compared with valproate as add-on therapy to carbamazepine in patients with partial-onset seizures. Epilepsia 2000 41(9) 1167-78. 

Bouget J, Chevret S, Chastang C, Raphael JC. Plasma exchange morbidity in Guillain-Barre syndrome results from the French prospective, randomized, multicenter study. The French Cooperative Group. Crit Care Med 1993 21(5) 651-8. 

Carr A, Emery S, Lloyd A, Hoy J, Garsia R, French M, Stewart G, Fyfe G, Cooper DA. Outpatient continuous intravenous interleukin-2 or snbcntaneous, polyethylene glycol-modified interlenkin-2 in hnman immunodeficiency virus-infected patients a randomized, controlled, multicenter study. Austrahan IL-2 Study Group. J Infect Dis 1998 178(4) 992-9. 

Hill JA, Winniford M, Cohen MB, Van Fossen DB, Murphy MJ, Halpem EF, Ludbrook PA, Wexler L, Rudnick MR, Goldfarb S. Multicenter trial of ionic versus nonionic contrast media for cardiac angiography. The lohexol Cooperative Study. Am J Cardiol 1993 72(ll) 770-5. 

Schmidt, U., P. J. Cooper, H. Essers, C. P. Freeman, R. L. Holland, R. L. Palmer, et al. (2004). Fluvoxamine and graded psychotherapy in the treatment of bulimia nervosa a randomized, double-blind, placebo-controlled, multicenter study of short-term and long-term pharmacotherapy combined with a stepped care approach to psychotherapy. J Clin Psychopharmacol 24(5) 549-52. 

Multicenter production of reference values is gaining acceptance, both as a theoretical concept and as a practical approach. A Spanish study introduced a cooperative model, simulating a virtual laboratory for 15 biochemical quantities. A recent project in the Nordic countries (NORIP ) was aimed at the production of common reference intervals for 25 analytes. 

Russell JC, Cooper CM, Ketchum CH, Torday JS, Richardson DK, Holt JA, et al. Multicenter evaluation of TDx test for assessing fetal lung maturity, Clin Chem 1989 35 1005-10. 

Morrison DA, Sethi G, Sacks J, et al. A multicenter, randomized trial of percutaneous coronary intervention versus bypass surgery in high-risk unstable angina patients. The AWESOME (Veterans Affairs Cooperative Study 385, Angina With Extremely Serious Operative Mortality Evaluation) investigators from the Cooperative Smdies Program of the Department of Veterans Affairs. Controlled CUn Trials 1999 20 601-619. 

Buchner T, Urbanitz D, Hiddemann W, et al. Intensified induction and consolidation with and without maintenance chemotherapy for acute myeloid leukemia (AML) two multicenter smdies of the German AML Cooperative Group. J Clin Oncol 1985 3 1583-1589. 

Consent forms may be based on the model form of a cooperative multicenter trial or follow local IRB guidelines. 

Ponec, R., Yuzhakov, G., and Cooper, D.L. (2004) Multicenter bonding and the structure of electron rich molecules. Model of the three-center four-electron bonding reconsidered. Theor. Chem. 

Spies JB, Cooper JM, Worthington-Kirsch R, lipman JC, Mills BB, Benenati JF (2004) Outcome of uterine embolization and hysterectomy for leiomyomas results of a multicenter study. Am J Obstet Gynecol 191 22-31... 

Descriptive epidemiology of the Multicenter ACL Revision Study (MARS) cohort. MARS Group, Wright RW, Huston LJ, Spindler KP, Dunn WR, Haas AK, Allen CR, Cooper DE, DeBerardino TM, Lantz BB, Mann BJ, Stuart MJ (2010) Descriptive epidemiology of the Multicenter ACL Revision Study (MARS) cohort. Am J Sports Med 38(10) 1979-1986. 

---