Multi-drug therapy

Development of drugs that target the progenitors of disease and multi-drug therapies that combat the different types of cancerous cells will be made possible by the ability... 

Liver damage may not only be caused by a certain substance, but also by an interaction of a combination of substances (e.g. multi-drug therapy, numerous constituents in plants) - moreover, this can happen in different individual ways. 

Dapsone in combination with trimethoprim is also used for the treatment of mild to moderate first episodes of TCP, or alone for PCP prophylaxis [115, 198]. The most frequent adverse events are dose related metheglobinemia and hemolytic anemia. Since multi-drug therapy began to be used in leprosy patients, an increasing number of a rare, idiosyncratic reaction with multiorgan involvement... 

Since type II poisoning involves a combined action on the CNS, adrenals, autonomic system, and muscle, multi-drug therapy may be needed. The combination of methocarbimol and atropine prevented all deaths at LDgo doses of pyrethroids in rats. 

Gentamicin and tobramycin are equally effective. Tobramycin has slightly better MICs to Pseudomonas. Amikacin generally is reserved for multi-drug resistant bacteria. Typically used as a short course of therapy followed by a switch to an oral agent. 

Tuberculosis Treatment of tuberculosis in combination with other active agents. It is most commonly used in patients with multi-drug resistant tuberculosis (MDR-TB) or in situations when therapy with isoniazid and rifampin is not possible because of a combination of resistance and intolerance. 

A 32-year-old Haitian man has acute-onset confusion and suicidal ideation. Two weeks ago he began combination therapy for multi-drug resistant pulmonary tuberculosis. He has a history of depression that required intermittent treatment in the past. Which of the following antitubercular agents is responsible for the patient s neurological symptoms ... 

The phenomenon of antibiotic resistance gives the public a significant stake in whether an individual completes or complies with therapy. For example, in the case of tuberculosis, an individual s failure to comply with the lengthy therapeutic regime can give rise to the development of multi-drug resistant strains (MDR-TB) of the disease, which are difficult and expensive to treat (Kim 2003). MDR-TB can spread... 

Acetylsalicylic acid is usually given by oral administration (0.5-8 g/day) for pain and inflammation and for antiplatelet therapy (75-100 mg/day). It is also available in rectal and topical formulations and as a soluble lysine derivative for intravenous or intramuscular application. Acetylsalicylic acid is often used in multi-drug preparations. The main side-effects are gastrointestinal disorders. Use in children is limited due to the risk of Reye s syndrome (Waldmann et al., 1982). The lithium, magnesium, calcium, and aluminium salts of acetylsalicylic acid are used in some special preparations. 

Efforts to promote medical applications of liposomes have permitted the development of several new drug formulations applicable to a broad range of therapeutics. One of the main areas of liposomes application is cancer therapy, A great number of scientists worldwide have focused their work on drug discovery or the improvement of the efficacy and reduction of the toxicity of known drugs. Two of the main problems in cancer chemotherapy are the toxicity of the known anticancer drugs and the multi drug resistance of certain cancer cells. 

The true chemotherapeutic significance of this phenomenon is not defined at the moment but it requires careful scrutiny since it involves so many drugs and so many organisms (Coli, Salmonella, Klebsiella, Shigella, Vibrio). Perhaps, by means of this new look at a bacterially old process, we will now be able to devise a cure for this "infectious disease" of bacteria which will be effective in vivo and will finally enable us to deal with the important problem of bacterial resistance (cf. a clinical study9 of atebrin in combination therapy of multi-drug-resistant urinary infections). 

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