Mullis

The change in the electronic redistribution on transferring the molecule from the gas phase to aqueous solution is another interesting issue. Analysis of the computed Mulli-ken charge population demonstrates a substantial change on the hydrogen and oxygen in... 

K. B. Mullis (La Jolla, California) invention of the polymerase chain reaction. 

Kary Banks Mullis (1944-) was bom in rural Lenoir, North Carolina did undergraduate work at Georgia Tech. and ieceived his Ph.O. at the University of California, Berkeley, in 1973. From 1979 to 1986 he worked at Cetus Corp., where his wor on developing PCR was carried out. Since 1988, he has followed his own drummer as self-employed consultant and writer. He received the 1993 Nobel Prize in chemistry. 

Moore, Stanford, 1030 Morphine, biosynthesis of, 969 specific rotation of, 296 structure of, 64 MR1, see Magnetic resonance imaging. 468-469 mRNA, see Messenger RNA MS, see Mass spectrometry Mullis, Kary Banks, 1117 Multiplct (NMR), 460 table of, 462... 

Mulli-RAFT agents have also been used to prepare segmented block... 

I he method of polymerization needs to be chosen for compatibility with functionality in the cores and the monomers to be used. Star block copolymers have also been reported. Mulli(bromo-compounds) may be used directly as ATRP initiators or they can be converted to RAFT agents. One of the most common... 

Mullis (M10), Bastress (B4), and Carlson and Seader (Cl) have conducted experimental studies to determine the heat-transfer characteristics of typical rocket-exhaust igniters. In these studies, the total rate of heat transfer to the propellant or simulated propellant surface was measured as a function of mass flow rate, geometry, and impingement angle between the igniter exhaust... 

Mullis made measurements of the heat flux for axially directed jets and for jets directed 30° to the motor axis. For the axially directed jets, Mullis found that the flux 4 to 10 diameters downstream of the contact point could be correlated by the boundary layer relations... 

For the region near the attachment point, Mullis found a strong effect of axial position on flux, but no satisfactory general correlation for this effect. In addition, he found no quantitative relation for the heat-transfer characteristics of jets directed toward the propellant surface. Under most conditions studied by Mullis, the radiation contribution is approximately 10% of the convective flux. The effects of solid-particle impingement were not investigated. 

M10. Mullis, B. G., Final Tech. Rept., Contract No. NAS 7-302, United Technology Center, Sunnyvale, California (September 1965). 

Mullie, F. and Reisse, J. Organic Matter in CarbonaceoTO Chondrites, 139, 83-117 (1986). Murakami, Y. Functionalited Cyclophanes as Catalysts and Enzyme Models. 115, 103-151 (1983). Mutter, M., and Pillai, V. N. R. New Perspectives in Polymer-Supported Peptide Synthesis. 106, 119-175(1982). 

Mullis, K. (1990), The unusual origin of the polymerase chain reaction, Sci. Am. (April), 56-65. 

The blue satellite peak associated with resonance line of rubidium (Rb) saturated with a noble gas was closely examined by Lepoint-Mullie et al. [10] They observed SL from RbCl aqueous solution and from a 1-octanol solution of rubidium 1-octanolate saturated with argon or krypton at a frequency of 20 kHz. Figure 13.4 shows the comparison of the SL spectra of the satellite peaks of Rb-Ar and Rb-Kr in water (Fig. 13.4b) and in 1-octanol (Fig. 13.4c) with the gas-phase fluorescence spectra (Fig. 13.4a) associated with the B —> X transition of Rb-Ar and Rb-Kr van der Waals molecules. The positions of the blue satellite peaks obtained in SL experiments, as indicated by arrows, exactly correspond to those obtained in the gas-phase fluorescence experiments. Lepoint-Mullie et al. attributed the blue satellites to B — X transitions of alkali-metal/rare-gas van der Waals species, which suggested that alkali-metal atom emission occurs inside cavitating bubbles. They estimated the intracavity relative density to be 18 from the shift of the resonance line by a similar procedure to that adopted by Sehgal et al. [14],... 

Then, the collisional interactions with rare-gas atoms result in the formation of electronically excited alkali-metal/rare-gas molecules. These van der Waals molecules emit light. Lepoint-Mullie et al. claimed that the site of SL from alkali-metal atoms is in the gas phase inside bubbles and that the SL is chemiluminescence. 

Lepoint-Mullie F, Voglet N, Lepoint T, Avni R (2001) Evidence for the emission of alkali-metal-noble-gas van der Waals molecules from cavitation bubbles. Ultrason Sonochem 8 151-158... 

Mullis, K.B., Faloona, F., Scharf, S., Saiki, R., Horn, G. and Erlich, H. (1986) Specific enzymatic amplification of DNA in vitro the polymerase chain reaction. Cold Spring Harbor Symposium of Quantitative Biology 51, 263—273. 

Saiki, R.K, Scharf, S.J., Faloona, F., Mullis, KB., Horn, G.T., Erlich, H.A. and Arnheim, N. (1985) Enzymatic amplification of [4-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. Science 230, 1350-1354. 

R. Saiki, D. Gelfand, S. Stoffel, S. Scharf, R. Higuchi, G. Horn, K. Mullis, and H. Erlich, Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 239, 487-491 (1988). 

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