Mucous membrane Irritant: Skin irritation

The threshold limit value (TLV) for cyclohexane is 300 ppm (1050 mg/m ). With prolonged exposure at 300 ppm and greater, cyclohexane may cause irritation to eyes, mucous membranes, and skin. At high concentrations, it is an anesthetic and narcosis may occur. Because of its relatively low chemical reactivity, toxicological research has not been concentrated on cyclohexane. 

Methanol is not classified as carcinogenic, but can be acutely toxic if ingested 100—250 mL may be fatal or result in blindness. The principal physiological effect is acidosis resulting from oxidation of methanol to formic acid. Methanol is a general irritant to the skin and mucous membranes. Prolonged skin contact with methanol vapor or Hquid can cause dermatitis. Methanol vapor can cause eye and respiratory tract irritation, nausea, headaches, and dizziness. 

Exposure to tantalum metal dust may cause eye injury and mucous-membrane irritation. The threshold limit value (TLV) in air is 5 mg/m, LD q is <400 mg/kg and the Occupational Safety and Health Administration (OSHA) time weighted average (TWA) exposure limit is 5 mg/m (47). The immediate dangerous to life or health (IDLH) concentration is 2500 mg/m (48). Whereas some skin injuries from tantalum have been reported, systemic industrial poisoning is apparently unknown (47). 

Diethyl pyrocarbonate (DEP) [1609-47-8] M 162.1, b 38-40°/12mm, 160-163 /atm, d 1.119, Op 1.398. Dissolve in Et20, wash with dilute HCl, H2O, dry over Na2S04. filter, evaporate and distil the residue first in vacuo then at atmospheric pressure. It is soluble in alcohols, esters, ketones and hydrocarbon solvents. A 50% w/w soln is usually prepared for general use. Treat with great CAUTION as DEP irritates the eyes, mucous membranes and skin. [Boehm and Mehta Chem Ber 71 1797 1938 Thoma and Rinke Justus Liebigs Ann Chem 624 30 1959.]... 

Vitamin K3 (2-methyl-l,4-naphthoquinone, Menadione, Menaphthone) [58-27-5] M 172.2, m 105-106", 105-107". Recrystd from 95% EtOH, or MeOH after filtration. Bright yellow crystals which are decomposed by light. Solubility in EtOH is 1.7% and in C6H6 it is 10%. It IRRITATES the mucous membranes and skin. [Fieser J Biol Chem 133 391 1940.]... 

In a broad evaluation also the sulfosuccinate disodium laureth sulfosuccinate (DLSS) was a part of a variety of surfactants tested for their dermatological mildness, and some different test methods were applied [16]. Products were compared applying in vitro methods (Zein test, hemolysis) and in vivo methods (Duhring-Chamber test, skin mildness by intracutaneous test on mice and topical application on hairless mice, mucous membrane irritation according to the Draize procedure on rabbit eyes). In the Duhring-Chamber test the DLSS elicited no reactions in the animal tests it ranged in the least irritant third of the 15 products tested. 

Colorless oily liquid with an acrid odor. This material is hazardous through inhalation, skin absorption, penetration through broken skin, and ingestion, and produces local skin/eye impacts. It causes severe irritation and burns to the eyes, mucous membranes, and skin cough, chest pain, and accumulation of fluid in the lungs (pulmonary edema). 

Hematological Effects. Routine blood parameters (hemoglobin, erythrocyte, leukocyte and thrombocyte levels) measured in 11 hexachloroethane workers did not differ from those of the controls (Selden et al. 1994). Plasma hexachloroethane levels in these workers, who wore protective equipment, were 7.3 + 6.04 pg/L at the time of the hematological analysis and 0.08 0.14 gg/L before production resinned (Selden et al. 1993). Mild skin and mucous membrane irritation were reported in the exposed group, suggesting that exposure may have been through either the inhalation or dermal routes of exposure. 

Exposure limits Potential occupational carcinogen. NIOSH REL IDLH 400 yes, mucous membranes, and skin. Inhalation may cause weakness and drowsiness (Patnaik, 1992). May cause blisters or burns (NIOSH, 1997). An irritation concentration of 1,125.00 mg/m in air was reported by Ruth (1986). 

Toxicology. Acetic acid vapor is a severe irritant of the eyes, mucous membranes, and skin chronic exposure may cause bronchitis and cracking and darkening of exposed skin. 

Toxicology. Allyl alcohol is a potent lacrima-tor and is an irritant of the mucous membranes and skin. 

Toxicology. Butylamine is an irritant of the eyes, mucous membranes, and skin. 

Cases of mild to moderate skin irritation and chloracne have been reported in workers exposed to O.lmg/m for several months. Levels of lOmg/m were unbearably irritating, presumably to mucous membranes and skin. Chloracne does not appear to occur at concentrations below O.lmg/mh... 

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